Spike-and-wave epilepsy in rats: Sex differences and inheritance of physiological traits

Jandó, Gábor; Carpi, Daniel; Kandel, Adam; Urioste, Ronald; Horváth, Zsolt; Pierre, E.; Vadi, D.; Vadász, Csaba; Buzsáki, György

doi:10.1016/0306-4522(94)00329-4

Cited by 70 publications

(41 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may explain previous findings in humans (3), monkeys (2), cats (5), and rats (4,13), which have demonstrated that neuronal population activities fluctuate at Ϸ0.1 Hz, and that these fluctuations are coherent over long distances (2,8). The amplitude of faster EEG oscillations (5)(6)(7)9), as well as the occurrence of discrete physiological EEG events (e.g., K complexes or arousals; refs.…”

Section: Discussionsupporting

confidence: 63%

“…The amplitude of faster EEG oscillations (5)(6)(7)9), as well as the occurrence of discrete physiological EEG events (e.g., K complexes or arousals; refs. 9, 10, and 12) and IIEs (4,11,13) have all been shown to exhibit fluctuations at 0.025-0.3 Hz.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to these relatively fast EEG oscillations, some studies have demonstrated infraslow fluctuations in, for instance, neuronal population activity (2-5), EEG power (5-9), discrete sleep events (arousals, spindles, K complexes) (9)(10)(11)(12), as well as in the occurrence of epileptic events (4,11,13). These observations have raised the possibility that the human cortex may generate infraslow oscillations (ISOs) underlying such fluctuations.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep

Vanhatalo

Palva

Holmes

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

453

397

View full text Add to dashboard Cite

Human cortical activity has been intensively examined at frequencies ranging from 0.5 Hz to several hundred Hz. Recent studies have, however, reported also infraslow fluctuations in neuronal population activity, magnitude of electroencephalographic oscillations, discrete sleep events, as well as in the occurrence of interictal events. Here we use direct current electroencephalography to demonstrate large-scale infraslow oscillations in the human cortex at frequencies ranging from 0.02 to 0.2 Hz. These oscillations, which are not detectable in conventional electroencephalography because of its limited recording bandwidth (typical lower limit 0.5 Hz), were observed in widespread cortical regions. Notably, the infraslow oscillations were strongly synchronized with faster activities, as well as with the interictal epileptic events and K complexes. Our findings suggest that the infraslow oscillations represent a slow, cyclic modulation of cortical gross excitability, providing also a putative mechanism for the as yet enigmatic aggravation of epileptic activity during sleep.epilepsy ͉ slow cortical oscillations ͉ phase synchrony ͉ direct current electroencephalography ͉ full-band electroencephalography A large body of literature has characterized functional and clinical correlates of cortical oscillatory activity seen in the human electroencephalography (EEG) at frequencies ranging from 0.5 Hz to several hundred Hz (1). In addition to these relatively fast EEG oscillations, some studies have demonstrated infraslow fluctuations in, for instance, neuronal population activity (2-5), EEG power (5-9), discrete sleep events (arousals, spindles, K complexes) (9-12), as well as in the occurrence of epileptic events (4, 11, 13). These observations have raised the possibility that the human cortex may generate infraslow oscillations (ISOs) underlying such fluctuations. ISOs are not detectable in conventional EEG because of its limited recording bandwidth (typical lower limit, 0.5 Hz; ref. 1).In the present study, we used direct current (DC)-coupled EEG scalp recordings (14-16) to demonstrate that ISOs are, in fact, a salient, large-scale feature of the human EEG. They were tightly associated with a cyclic modulation of fast EEG activity as well as discrete EEG events such as K complexes and interictal activity. In analogy with recent studies demonstrating that slow delta oscillations (0.5-1 Hz) may modulate brain excitability (17, 18), our data points to a role of ISOs in the control of gross cortical excitability. Our findings also provide a window on the modulation of interictal epileptiform events (IIEs) and on sleep-epilepsy interactions in the human brain. MethodsSubjects and EEG Recording. We studied 16 subjects (four females; average age, 34.3 years; range, 16-51 years) during overnight (n ϭ 9) or daytime (n ϭ 7) sleep. This study was approved by the Human Subjects Committee of the University of Washington. Twelve subjects were recorded using a custom-made 16-channel DC-coupled EEG amplifier and Ag͞AgCl electrodes (refs....

show abstract

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep

Vanhatalo

Palva

Holmes

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

453

397

View full text Add to dashboard Cite

show abstract

“…We performed the same experiments in Wistar rats (n ϭ 4), from which the WAG/Rij strain was originally inbred. Importantly, seizure susceptibility is also high and increases with age in many outbred rat strains, including Wistar rats (Jandó et al 1995;Vergnes et al 1982). In all animals, the opsin expressed well and gave rise to strong optically evoked bursting responses.…”

Section: Frequency-specific Optically Evoked Rhythmic Population Bursmentioning

confidence: 99%

“…However, a causal demonstration that rhythmic firing or bursting actually triggers absence seizures is still lacking. It is possible that these rhythmic oscillations preceding seizure onset have no causal role and simply reflect an underlying process driving the transition into the ictal state (e.g., Jirsa et al 2014).…”

mentioning

confidence: 99%

Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy

Wagner

Truccolo

Wang

et al. 2015

Journal of Neurophysiology

View full text Add to dashboard Cite

Wagner FB, Truccolo W, Wang J, Nurmikko AV. Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy. J Neurophysiol 113: 2321-2341, 2015. First published December 31, 2014 doi:10.1152/jn.01040.2014.-Transitions into primary generalized epileptic seizures occur abruptly and synchronously across the brain. Their potential triggers remain unknown. We used optogenetics to causally test the hypothesis that rhythmic population bursting of excitatory neurons in a local neocortical region can rapidly trigger absence seizures. Most previous studies have been purely correlational, and it remains unclear whether epileptiform events induced by rhythmic stimulation (e.g., sensory/ electrical) mimic actual spontaneous seizures, especially regarding their spatiotemporal dynamics. In this study, we used a novel combination of intracortical optogenetic stimulation and microelectrode array recordings in freely moving WAG/Rij rats, a model of absence epilepsy with a cortical focus in the somatosensory cortex (SI). We report three main findings: 1) Brief rhythmic bursting, evoked by optical stimulation of neocortical excitatory neurons at frequencies around 10 Hz, induced seizures consisting of self-sustained spikewave discharges (SWDs) for about 10% of stimulation trials. The probability of inducing seizures was frequency-dependent, reaching a maximum at 10 Hz. 2) Local field potential power before stimulation and response amplitudes during stimulation both predicted seizure induction, demonstrating a modulatory effect of brain states and neural excitation levels. 3) Evoked responses during stimulation propagated as cortical waves, likely reaching the cortical focus, which in turn generated self-sustained SWDs after stimulation was terminated. Importantly, SWDs during induced and spontaneous seizures propagated with the same spatiotemporal dynamics. Our findings demonstrate that local rhythmic bursting of excitatory neurons in neocortex at particular frequencies, under susceptible ongoing brain states, is sufficient to trigger primary generalized seizures with stereotypical spatiotemporal dynamics.

show abstract

Genetic threshold hypothesis of neocortical spike‐and‐wave discharges in the rat: An animal model of petit mal epilepsy

et al. 1995

Self Cite

View full text Add to dashboard Cite

Neocortical high-voltage spike-and-wave discharges (HVS) in the rat are an animal model of petit mal epilepsy. Genetic analysis of total duration of HVS (s/12 hr) in reciprocal F1 and F2 hybrids of F344 and BN rats indicated that the phenotypic variability of HVS cannot be explained by a simple, monogenic Mendelian model. Biometrical analysis suggested the presence of additive, dominance, and sex-linked-epistatic effects, buffering maternal influence, and heterosis. High correlation was observed between average duration (s/episode) and frequency of occurrence of spike-and-wave episodes (n/12 hr) in parental and segregating generations, indicating that common genes affect both duration and frequency of the spike-and-wave pattern. We propose that both genetic and developmental-environmental factors control an underlying quantitative variable, which, above a certain threshold level, precipitates HVS discharges. These findings, together with the recent availability of rat DNA markers for total genome mapping, pave the way to the identification of genes that control the susceptibility of the brain to spike-and-wave discharges.

show abstract

Spike-and-wave epilepsy in rats: Sex differences and inheritance of physiological traits

Cited by 70 publications

References 57 publications

Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep

Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep

Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy

Genetic threshold hypothesis of neocortical spike‐and‐wave discharges in the rat: An animal model of petit mal epilepsy

Contact Info

Product

Resources

About