Spindle Cell Carcinoma of the Upper Aerodigestive Tract

Gerry, Daniel; Fritsch, Valerie A.; Lentsch, Eric J.

doi:10.1177/0003489414525337

Cited by 49 publications

(33 citation statements)

References 11 publications

(22 reference statements)

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“…Intrinsic tumor properties and lack of standard treatment guidelines may be the possible explanations for the unfavorable prognosis. However, SpCC showed site specific prognosis [16–18]. In this study we compared obtainable treatment modalities (Figures 2J and 3J).…”

Section: Discussionmentioning

confidence: 99%

Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

et al. 2017

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BackgroundOwing to the rarity, the general demographics, basic clinico-pathologic features, management, outcome and prognostic factors of spindle cell carcinoma (SpCC) were unexplored.MethodsA SEER analysis was performed with 2336 cases (1973-2016).ResultsA peak incidence occurred at 70~80 years without any gender predominance and 83.13% occurred in white people. The respiratory system was mostly affected tumor site (35%). Significant overall survival (OS) and disease specific survival (DSS) were found differentiated in gender, age, marital status, primary tumor location, AJCC stage, T stage, N stage, M stage, pathologic grade and treatment modality. In the multivariate Cox model, the age > 69 years (Hazard ratio [HR] = 1.427 for OS, P = 0.01 and HR = 1.491 for DSS, P = 0.003; Reference [Ref] age ≤ 69 years), tumor location in respiratory system (HR = 1.550 for OS, P = 0.041 and HR = 1.561 for DSS, P = 0.04; Ref: digestive system), N2 stage (HR = 1.962 for OS, P = 0.006 and HR = 1.982 for DSS, P = 0.004; Ref: N0 stage) and AJCC stage IV (HR = 4.601 for OS, P = 0.000 and HR = 5.107 for DSS, P = 0.000; Ref: stage I) were independently associated with worse OS and DSS.ConclusionsSpCC mostly occurred in white people at 70~80 years old without predominance in any gender. The respiratory system was mostly affected site. The patient's age, primary tumor location, AJCC stage were independent prognostic indicators for both DSS and OS of SpCC.

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Section: Discussionmentioning

confidence: 99%

Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

et al. 2017

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“…SpCC is an aggressive malignant tumor typically observed in upper aerodigestive tract, in which nearly half of the cases are of larynx origin [6]. It was first reported in the literature in 1933 by Figi, under the name of “larynx sarcoma” [7].…”

Section: Discussionmentioning

confidence: 99%

Spindle Cell Carcinoma of the Larynx: A Confusing Diagnosis for the Pathologist and Clinician

Bostancı

Özbilim

Turhan

2015

Case Reports in Otolaryngology

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Laryngeal spindle cell carcinoma (SpCC) is an uncommon subtype of squamous cell carcinoma which represents 0.5% of all laryngeal squamous cell carcinomas. It is a biphasic tumor consisting of the combination of a malignant mesenchymal spindle cell component and a squamous cell component that includes dysplasia, carcinoma in situ, or invasive carcinoma. Although it has aggressive biological features, the probability of making a diagnosis in the early stages is high as it often leads to obstructive symptoms in the early period. Due to its low incidence, there is no clear consensus on prognostic factors and optimal treatment strategies yet. In this paper, a 60-year-old laryngeal SpCC case that was effectively treated with wide local excision followed by adjuvant radiotherapy was presented with the literature.

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“…Carcinosarcoma has been reported in the respiratory tract, gastrointestinal tract, urogenital tract, and other sites. Although various reports have described spindle cell carcinoma in the head and neck, 1 – 9 carcinosarcoma is rare in the larynx and hypopharynx. Of all malignant neoplasms, carcinosarcomas originating in the larynx or hypopharynx account for <1%.…”

Section: Introductionmentioning

confidence: 99%

True hypopharyngeal carcinosarcoma: a case report and literature review

et al. 2018

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ObjectiveCarcinosarcoma consists of carcinomatous and sarcomatous tissues and is an aggressive malignant tumor. It is rarely reported in the hypopharynx.MethodsA 72-year-old man presented with dysphagia and dyspnea. Laryngoscopy, computed tomography (CT), and 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) showed a neoplasm on the left posterior hypopharyngeal wall. The patient underwent bilateral neck dissection and excision of the hypopharyngeal cancer followed by postoperative radiation therapy.ResultsImmunohistochemistry revealed carcinomatous cells with membrane positivity for cytokeratin, glucose transporter-1 (GLUT-1), phosphoinositide-3 kinase (PI3K), hypoxia-inducible factor-1α (HIF-1α), and hexokinase-II as well as sarcomatous cells with membrane positivity for smooth muscle actin, GLUT-1, HIF-1α, and PI3K. Histopathology and immunohistochemistry revealed a true carcinosarcoma of the hypopharynx (pT3N0M0, Stage III).ConclusionsThorough immunohistochemistry is required for a correct diagnosis of hypopharyngeal carcinosarcoma. 18F-FDG PET/CT may help to distinguish hypopharyngeal carcinosarcoma from benign tumors.

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Spindle Cell Carcinoma of the Upper Aerodigestive Tract

Abstract: SpCC of the head and neck is more likely than SCC to present at an early stage, with fewer nodal metastases. Survival rates appear to depend on anatomic site as well.

Cited by 49 publications

References 11 publications

Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

Spindle Cell Carcinoma of the Larynx: A Confusing Diagnosis for the Pathologist and Clinician

True hypopharyngeal carcinosarcoma: a case report and literature review

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