Spindle Cell Carcinoma of the Breast: MR Findings Correlated with Histopathology

Abstract

We correlateˆndings from magnetic resonance (MR) imaging and pathology in a 55-year-old woman with spindle cell carcinoma of the breast. Pathological examination showed aˆbrous capsule at the margins and abundantˆbromyxoid stroma within the mass. Spindle cell carcinoma may be included in the diŠerential diagnosis of expanding round masses with internal components that demonstrate rapid initial enhancement with high signal intensity on T 2 -weighted images in postmenopausal women.

Spindle Cell Carcinoma of the Breast: Investigation of Magnetic Resonance Imaging Features of 26 Cases

“…Of 5 tumors available MRI-pathological correlation, 3 tumors showed hypointense rim on FST2WI, and all corresponded to a fibrous capsule (sensitivity, 75%; positive predictive value, 100%). It has been reported that 1 case of SpCC showed a heterogeneous, hyperintense, oval mass with an irregular hypointense rim on FST2WI, which corresponded with a fibrous capsule at the margin of the tumor on pathological findings 17 . As for the hypointense rim on FST2WI, Isomoto et al 17 supposed that it indicated an expanding growth pattern of the tumor.…”

“…It has been reported that 1 case of SpCC showed a heterogeneous, hyperintense, oval mass with an irregular hypointense rim on FST2WI, which corresponded with a fibrous capsule at the margin of the tumor on pathological findings. 17 As for the hypointense rim on FST2WI, Isomoto et al 17 supposed that it indicated an expanding growth pattern of the tumor. However, in our cases, it did not correlate with tumor size.…”

“…3 However, current data on MRI findings of SpCC are largely derived from published case reports and small case series. 7,[16][17][18][19][20] We retrospectively investigated MRI features, clinical information, and preoperative pathological biopsy diagnosis among SpCC cases diagnosed with postoperative surgical specimen and tumor characteristics, and treatment management from 2 institutions for 10 years.…”

“…It has been reported that magnetic resonance imaging (MRI) findings of metaplastic carcinoma show an irregular spiculated mass with decreased T1 signal intensity, increased T2 signal intensity, and variable enhancement 3 . However, current data on MRI findings of SpCC are largely derived from published case reports and small case series 7,16–20 …”

Spindle cell metaplastic carcinoma of breast: A clinicopathological and immunohistochemical analysis

“…Spindle cell metaplastic carcinoma (SpCMC) of the breast is a rare variant of breast cancer that has been classified under the category of metaplastic carcinoma (MC), a distinct entity within the group of undifferentiated invasive carcinomas, according to the World Health Organization (WHO) . Although this subtype was not continued into the following editions of WHO, it was still used in some newly published works . In the 4th edition of the WHO classification of breast tumors, it was definitely classified into the MC subtypes…”