Morphological features of mandibular 3rd molar are always unpredictable, andshow a discrepancy by way of different individual. Nevertheless, restorative, prosthetic andorthodontic concerns of these mandibular third molars require root canal treatment in turn topreserve functional elements in the jaw. The variation in the root canal anatomy presents clinicalchallenges and difficulties for clinician to undertake endodontic therapy. Therefore it’s veryessential for practitioners must have adequate knowledge of the internal morphology of rootcanal system, use all techniques, equipments is mandatory to treat the entire root canal system.Study Design: Cross-sectional. Setting: Department: Operative Dentistry, Faculty of Dentistry,Liaquat University of Medical & Health Sciences, Jamshoro. Period: February 2014 to March2016. Methodology: Overall 200 patients of mandibular 3rd molar (fully erupted in the jaw)were enrolled with indicative irreversible pulpitis, Were endodontically treated by conventionalmethod using stainless steel hand files, contra-angle small head hand peace by postgraduatetrainee. After opening of access cavity, every canal was positioned radiographically by the handfiles placed within the canals. Results: Among 200 patients of mandibular third molars wereevaluated by conventionally endodontic treatment, Out of 200 patients were found to havea practical errors in the 65 cases and rest of the 135 cases were treated without any errors.Number of canal configuration has found in lower 3rd molar teeth, one canal contained in4(2.0%) teeth, two canals in 33(16.5%) teeth, three canals in 160(80%) teeth and four in 3(1.5%)teeth. Conclusion: Mandibular third molars showed huge anatomic irregularity. Numberof canals has provided by this study to the practitioner with an understanding of the clinicalrecommended for lowers third molars.