Spontaneous clearance of hepatitis C infection after liver transplantation from IL28B rs12979860 CC donors

Abstract

Genetic polymorphisms adjacent to IL28B have been previously associated with spontaneous clearance of hepatitis C virus (HCV) and a higher rate of sustained virological response to interferon-based treatment in HCV genotype 1-infected patients. A recent study has shown that patients with the CC genotype of the rs12979860 single nucleotide polymorphism upstream from the IL28B gene are more likely to clear HCV spontaneously relative to the CT or TT genotype. In the liver transplant cohort, HCV recurs almost universally in patients with detectable HCV RNA at the time of transplantation. The spontaneous clearance of HCV infection after transplant is very rare. We report two cases of spontaneous clearance of HCV genotype 1 infection after liver transplantation from homozygous IL28B CC donors. This finding may be explained by alterations in the host immune responses to HCV after transplantation with a CC donor liver, which has potential implications for donor selection in HCV-positive recipients.

Spontaneous Clearance of Hepatitis C Genotype 4 After Liver Retransplantation

“…That finding may be explained by alterations in the host immune responses to HCV after transplantation with IL28B CC donor liver, which may have potential implications for donor selection in HCV-positive recipients [18].…”

Eliminación espontánea de virus hepatitis C en trasplantado hepático: a propósito de dos casos

“…Los polimorfismos de IL28B también inciden en la eliminación del VHC. Hay estudios en no trasplantados que muestran que ciertos genotipos de algunos polimorfismos se asocian a mayor probabilidad de eliminación espontánea 22 y existe un reporte de dos casos en que los hígados donados tenían el genotipo CC del polimorfismo rs12979860, atribuyendo la eliminación a este genotipo más favorecedor 16 . En búsqueda de esta relación, en uno de los donantes de nuestros pacientes (JV) logramos determinar los polimorfismos rs12979860 y rs8099917, que fueron CT y TG respectivamente.…”

“…La mayoría de estos pacientes se trasplantan sin haber logrado eliminar el VHC previo al trasplante, y en estos la infección del nuevo hígado es casi invariable 3 . Sin embargo, existen algunos casos aislados en la literatura de pacientes que después del trasplante, y sin terapia antiviral de por medio, logran eliminar el VHC [4][5][6][7][8][9][10][11][12][13][14][15][16] (Tabla 1). Presentamos dos casos con eliminación espontánea de VHC.…”

Spontaneous Clearance of Hepatitis C Virus after Liver Transplantation, A Report of Two Cases

“…Spontaneous clearance of HCV is rare in the immunocompromised patients post liver transplantation. There are only few case reports about spontaneous clearance of HCV after liver and renal transplantation particularly after withdrawal of immunosuppressive agents [8,[11][12][13][14]. Here we report on the clinical features of two patients with spontaneous clearance after liver transplantation.…”

“…Different reports had identified different speculative factors for viral clearance; withdrawal of immunosuppression [8,24], renal impairment, proteinuria, pretransplant exposure to interferon, and change of immunosuppression, antiretroviral therapy given for HIV coinfection or HBV coinfection [23], liver transplantation from homozygous IL28B CC donors [11].…”