Spontaneous formation of drug-containing acrylic nanoparticles

Abstract

Nanoparticles containing ibuprofen, indomethacin or propranolol were formed spontaneously after the addition of solutions of the drugs and acrylic polymers (Eudragit RS or RL 100) in the water-miscible solvents, acetone or ethanol, to water without sonication or microfluidization. The colloidal dispersions were stabilized by quaternary ammonium groups and did not require the addition of surfactants or polymeric stabilizers. The nanoparticles were compared to nanoparticles prepared either by a microfluidization-solvent evaporation method with a water-immiscible organic solvent, methylene chloride, or by a melt method with respect to particle size and redispersibility of freeze- or spray-dried samples. Nanoparticles prepared by microfluidization or the melt method were easily redispersed while Eudragit RS nanoparticles prepared by spontaneous emulsification were not redispersible. Flexible films were formed from the nanosuspensions after the addition of 15 per cent triethyl citrate, a water-soluble plasticizer. The release of propranolol from the films increased with increasing proportion of RL, but was independent of the order of mixing of the two polymers or nanosuspensions during film preparation. The drug release from indomethacin films was increased by adding water-soluble polymers to the nanosuspension.

Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis

“…For this reason, the present study aimed to develop a mucoadhesive NP formulation with FLZ that provides extended residence time and effective treatment of OC after buccal application. The NPs were prepared by adapting the spontaneous emulsification technique previously described by Bodmeier et al 25 The main advantage of this technique is the avoidance of using toxic organic solvents. The coated NPs were characterized in terms of PS, ZP, drug EE, and DL capacity.…”

“…The NPs were prepared adapting the spontaneous emulsification technique previously described by Bodmeier et al 25 Specified amounts of EUD polymers and FLZ were dissolved in 25 mL ethanol. The alcoholic solution mixture was added dropwise (3 mL/min) to 50 mL of distilled water under continuous magnetic stirring at 800 rpm.…”

“…EUD polymers have been proposed for use in various studies because of their good stability, reproducible release rates of active substance, and mucosal tolerability. [23][24][25] In this context, the objective of this investigation was to develop a suitable mucoadhesive NP formulation with FLZ and to examine its efficacy for the treatment of OC by evaluation of its cytotoxicity and in vitro and in vivo antifungal activity.…”

Nanoparticles from vesicles polymerization. II. Evaluation of their encapsulation capacity

“…The most popular are gel filtration, [17][18][19][20][21] ultrafiltration, [21][22][23] and ultracentrifugation. 24,25 Once the free fraction is separated from the nanoparticles bound fraction, the evaluation of the encapsulation rate is determined by the appropriate analytical method (GPC, 26 spectrophotometry UV/vis, 27 radioactivity measurement, 27 . .…”

Development and in vitro Evaluation of Voriconazole Nanoparticle Formulation for Mucosal Application

“…The NPs were prepared by adapting the spontaneous emulsification technique previously described by Bodmeier et al 17 The final preparation method was established in accordance with Rençber et al's 18 study. In brief, 2.5% of EUD RS polymer and 0.05% VRZ were dissolved in 25 mL ethanol.…”