Spontaneous lesions in endocrine glands of experimental Wistar rats and beagle dogs

Nataraju, G.J.; Ranvir, Ramchandra; Kothule, Viren; Kadam, Shekhar; Ravichandra, B.V.; Bhatnagar, Upendra; Jain, Mukul

doi:10.1016/j.etp.2015.09.002

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…It is known that the ageing process is associated with CCH of the thyroid gland in humans (Gibson et al, 1982). A varying incidence of spontaneous proliferative changes of rat thyroid C-cells was also found in older rats (Haschek et al, 2013;Nataraju et al, 2016). CCH is classified as physiological/reactive and neoplastic (Perry et al, 1996).…”

Section: Discussion and Concluding Remarksmentioning

confidence: 82%

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Age-Related Changes in Calcitonin-Producing Thyroid C-Cells of Male Wistar Rats

Filipović

Ajdžanović

Živanović

et al. 2022

Microscopy and Microanalysis

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Thyroid C-cells secrete the hormone calcitonin (CT) which acts as an inhibitor of bone resorption. Our aim was to examine the age-related changes in the structure and function of CT-producing C-cells, using histomorphometric, ultrastructural, and biochemical analyses. We used young adult (3-months-old), middle-aged (16-months-old), and old (24-months-old) male rats. The peroxidase-antiperoxidase method was applied for localization of CT. Stereological analysis was performed using the newCAST stereological software package. Serum samples were analyzed for the determination of CT, testosterone (T), calcium (Ca2+), and phosphorus (P). We found a significant increase in the volume density (Vv) of C-cells in both older groups (p < 0.05). The percentage of smaller volume range C-cells increased (p < 0.0001), while the proportion of greater volume range C-cells decreased (p < 0.05) with ageing. Ultrastructural analysis revealed a larger number of secretory granules in older rats. Serum CT increased (p < 0.001), while serum T and P were reduced (p < 0.01) in older rats. Serum Ca2+ was lower (p < 0.0001) in middle-aged rats compared to young adults. We revealed a 20% incidence of C-cell hyperplasia in older rats and one case of medullary thyroid carcinoma in an old rat. Our findings indicate that the ageing process causes significant histomorphometric changes at the thyroid C-cell level.

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Section: Discussion and Concluding Remarksmentioning

confidence: 82%

“…In aged rats, a higher incidence of C-cell hyperplasia (CCH) was observed, which was characterized by an increased mass of these cells in both sexes (Nataraju et al, 2016). There are several different criteria for the diagnosis of CCH.…”

Section: Introductionmentioning

confidence: 99%

Age-Related Changes in Calcitonin-Producing Thyroid C-Cells of Male Wistar Rats

Filipović

Ajdžanović

Živanović

et al. 2022

Microscopy and Microanalysis

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“…In rodent toxicity studies, spontaneous pituitary neoplasms are frequently encountered 10 . The incidence appears to vary with many factors, including species/strains, age, sex, and reproductive status 11 , 12 , 13 . Among these factors, it is known that there is a striking degree of strain variation in the incidence of pituitary tumors in rats, which has been reported to range from 10% to more than 90% 3 .…”

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confidence: 99%

Historical control background incidence of spontaneous pituitary gland lesions of Han-Wistar and Sprague-Dawley rats and CD-1 mice used in 104-week carcinogenicity studies

et al. 2017

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The aim of this study was to determine the range and incidences of spontaneous microscopic lesions of the pituitary gland in control Han-Wistar and Sprague-Dawley rats and CD-1 mice from 104-week carcinogenicity studies carried out between 1998 and 2010 at Charles River Edinburgh. In both strains of rats and in CD-1 mice, non-proliferative lesions of the pituitary gland were generally uncommon, excluding cysts/pseudocysts (6.42% in Han-Wistar rats, 5.85% in Sprague-Dawley rats, and 2.08% in CD-1 mice). Primary proliferative lesions were most frequently found in the pars distalis of the pituitary gland. Adenomas and carcinomas of the pars distalis were more common in Sprague-Dawley rats (49.33% and 2.85%, respectively) than in Han-Wistar rats (27.29% and 0.21%, respectively), and adenomas in both strains of rats and CD-1 mice exhibited a marked sex predisposition, with females more commonly affected.

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Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits

et al. 2021

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Animals are valuable resources in biomedical research in investigations of biological processes, disease pathogenesis, therapeutic interventions, safety, toxicity, and carcinogenicity. Interpretation of data from animals requires knowledge not only of the processes or diseases (pathophysiology) under study but also recognition of spontaneous conditions and background lesions (pathology) that can influence or confound the study results. Species, strain/stock, sex, age, anatomy, physiology, spontaneous diseases (noninfectious and infectious), and neoplasia impact experimental results and interpretation as well as animal welfare. This review and the references selected aim to provide a pathology resource for researchers, pathologists, and veterinary personnel who strive to achieve research rigor and validity and must understand the spectrum of “normal” and expected conditions to accurately identify research-relevant experimental phenotypes as well as unusual illness, pathology, or other conditions that can compromise studies involving laboratory mice, rats, gerbils, guinea pigs, hamsters, naked mole rats, and rabbits.

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Spontaneous lesions in endocrine glands of experimental Wistar rats and beagle dogs

Cited by 3 publications

References 21 publications

Age-Related Changes in Calcitonin-Producing Thyroid C-Cells of Male Wistar Rats

Age-Related Changes in Calcitonin-Producing Thyroid C-Cells of Male Wistar Rats

Historical control background incidence of spontaneous pituitary gland lesions of Han-Wistar and Sprague-Dawley rats and CD-1 mice used in 104-week carcinogenicity studies

Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits

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