Spontaneous liver rupture in hypereosinophilic syndrome: Arare but fatal complication

Abstract

We report a rare case of spontaneous liver rupture in a patient with hypereosinophilic syndrome (HES), of which the diagnosis was delayed, resulting in a fatal outcome. The diagnostic criteria and treatment of HES with hepatic involvement were reviewed. The possible cause of spontaneous liver rupture in HES and its management were also discussed. To our knowledge, this is the first case report of spontaneous liver rupture in HES. We emphasized the need of a high index of suspicion in diagnosing HES, so that early treatment could be initiated.

An alarming but self-limited case of isolated large spontaneous liver hematoma in pregnancy

“…There have been over 100 cases reported in the literature, with the majority being associated with pregnancy-induced-hypertension as well as primary and metastatic liver tumors [4, 5]. This has also been described in patients with HELLP syndrome, Ehlers Danlos disease and graft-vs-host disease [6–8]. There is an almost exclusive association with severe preeclampsia or with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), as more than 80% of cases occur in patients with preeclampsia/eclampsia and/or HELLP syndrome [2].…”

Spontaneous liver rupture: A report of two cases

“…[1] Other causes are primary, benign, and malignant liver tumors, liver cirrhosis, amyloidosis, malaria, venous stasis, secondary tumors in the liver, and hypereosiniphilic syndrome. [2] Hepatic rupture is common in the right lobe of liver due to larger size. [3]…”

Spontaneous Hepatic Rupture with Intraperitoneal Hemorrhage without Underlying Etiology: A Report of Two Cases

“…Massive hemoperitoneum caused by spontaneous rupture of the liver is a rare event, most often associated with benign and malignant hepatic neoplasms [ 1 ]. There have been several reports in the literature of liver hemorrhage related to pregnancy [ 2 ], and other more rare conditions such as coagulation disturbances [ 3 ], connective tissue disease [ 4 ], and hypereosinophilic syndrome [ 5 ]. However, hepatic rupture in the absence of underlying pathology is an extremely rare occurrence.…”