Spontaneously complete regression of pseudolymphoma of the remnant pancreas after pancreaticoduodenectomy

Nakata, Bunzo; Amano, Ryosuke; Matsuoka, Junko; Sugimori, Satoshi; Ohsawa, Masahiko; Wakasa, Kenichi; Egashira, Yasuyuki; Kimura, Kengo; Yamada, Naoki; Hirakawa, Kenji

doi:10.1016/j.pan.2012.02.011

Cited by 10 publications

(11 citation statements)

References 17 publications

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“…Similar to this study, in most of the previous reports pancreatic cancer or neuroendocrine tumours were suspected pre‐operatively . Therefore, surgical resection was performed in almost all reported patients.…”

Section: Discussionsupporting

confidence: 83%

“…proposed a third form of chronic pancreatitis, namely follicular pancreatitis, which is characterised histopathologically by the presence of duct‐centred, dense lymphoplasmacytic infiltration with many reactive lymphoid follicles bearing germinal centres. This condition may be under‐recognised and may have been previously reported as pancreatic pseudolymphoma or reactive lymphoid hyperplasia . To the best of our knowledge, only 13 patients have been reported in the English language literature, and only two patient series have been published .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, abundant infiltration of CD4 + /CD25 + T reg cells is also observed in IgG4‐related AIP lesions, and a higher expression of FoxP3 mRNA is also noted . However, the immunological characteristics of follicular pancreatitis have not been examined . Thus, we studied the clinicopathological characteristics of three patients with follicular pancreatitis and assessed the gene expression profile of this disorder.…”

Section: Introductionmentioning

confidence: 99%

“…This condition may be under-recognised and may have been previously reported as pancreatic pseudolymphoma or reactive lymphoid hyperplasia. [5][6][7][8][9][10] To the best of our knowledge, only 13 patients have been reported in the English language literature, [4][5][6][7][8][9][10][11] and only two patient series have been published. 4,11 The immunological characteristics of immunoglobulin (Ig)G4-related AIP have been established.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and immunological features of follicular pancreatitis – a distinct disease entity characterised by Th17 activation

et al. 2019

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Aim Follicular pancreatitis is a recently recognised, distinct clinicopathological entity characterised by the presence of many intrapancreatic lymphoid follicles with reactive germinal centres. However, the clinicopathological and immunological features and causes have not yet been established. We assessed the clinicopathological and immunological profiles of patients with follicular pancreatitis who underwent surgery. Methods and results This study included three patients with pancreatic masses (age range = 62–75 years; women:men: 1:2). A histopathological study of the resected pancreatic masses revealed abundant lymphoid follicles with reactive germinal centres in both periductal regions and diffusely within the parenchyma. No storiform fibrosis, obliterative phlebitis or granulocytic epithelial lesions were observed. The immunohistochemical examination revealed an IgG4/IgG‐positive plasma cell ratio <30% in all patients. Podoplanin (Th17 marker)‐expressing lymphocytes were present in the lymphoid follicles of those with follicular pancreatitis, whereas these were absent in normal lymph nodes and in lymphoid follicles of those with IgG4‐related autoimmune pancreatitis (AIP). An RNA digital counting assay clearly demonstrated that the expression counts of 20 genes, including dendritic cells and lymphoid follicles markers, and related cytokines were significantly higher in follicular pancreatitis than in IgG4‐related AIP (P < 0.01). The expressions of CCR6 and IL23A, which are genes related to Th17, were high. Conclusions This study shows that follicular pancreatitis is a histopathologically and immunologically distinct disease entity of pancreatitis and is characterised by upregulated Th17 expression.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and immunological features of follicular pancreatitis – a distinct disease entity characterised by Th17 activation

et al. 2019

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“…Similarly, pancreatic localized lymphoid hyperplasia or pseudolymphoma shows lymphoid follicles composed of germinal centers surrounded by rims of lymphocytes, and lymphoplasmacytic infiltration with an increased collagenous stroma [19,20]. In addition, Zen et al proposed a disease entity named follicular cholangitis and pancreatitis, which showed prominent duct-centered lymphoplasmacytic infiltration and lymphoid follicles with collagenous fibrosis in a pancreatobiliary lesion [11].…”

Section: Discussionmentioning

confidence: 99%

Primary Hepatic Lymphoma Complicated by a Hepatic Inflammatory Pseudotumor and Tumor-Forming Pancreatitis

Kaneko

Mitomi

Nakazaki

et al. 2017

JGLD

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Background: Hepatic inflammatory pseudotumor (IPT) is considered to be benign in biological behavior, and its malignant transformation is extremely rare. There has only been one published case of primary hepatic lymphoma complicated by hepatic IPT.Case presentation: A 73-year-old man presented with obstructive jaundice and a pancreatic head mass. Histology of the mass revealed chronic pancreatitis with lymphoid follicle formation, leading to a diagnosis of a suspicion of follicular pancreatitis. After a choledochojejunostomy, a hepatic tumor was detected, and a biopsy revealed lymphoplasmacytic infiltration. Immunohistochemistry confirmed the polyclonal nature of lymphoplasma cells, indicative of an IPT. The hepatic tumor disappeared during follow-up, but the patient exhibited a high fever related to tumor recurrence. A biopsy revealed the co-existence of a diffuse large B-cell lymphoma and an IPT. IgG4-related disease was excluded because storiform fibrosis, obliterative phlebitis, and a significant increase in IgG4-immunoreactive cells were absent in all investigated tissues. The tumor completely disappeared after chemotherapy.Conclusion: Careful observation is necessary in this kind of situation because the presence of a hepatic IPT may represent an increased risk of malignant transformation.Abbreviations: IPT: inflammatory pseudotumor; DLBCL: diffuse large B-cell lymphoma; CT: computed tomography; LDH: lactate dehydrogenase; sIL-2R: soluble interleukin-2 receptor; EBER: Epstein-Barr virus-encoded small RNA; R-CHOP: rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone

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Rare Tumors of the Pancreas

Haeberle

Insilla

Espósito

2021

Textbook of Pancreatic Cancer

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Spontaneously complete regression of pseudolymphoma of the remnant pancreas after pancreaticoduodenectomy

Cited by 10 publications

References 17 publications

Clinicopathological and immunological features of follicular pancreatitis – a distinct disease entity characterised by Th17 activation

Clinicopathological and immunological features of follicular pancreatitis – a distinct disease entity characterised by Th17 activation

Primary Hepatic Lymphoma Complicated by a Hepatic Inflammatory Pseudotumor and Tumor-Forming Pancreatitis

Rare Tumors of the Pancreas

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