Sportomics in professional soccer players: metabolomics results during preseason

Pintus, Roberta; Bongiovanni, Tindaro; Corbu, Sara; Francavilla, Vincenzo Cristian; Dessì, Angelica; Noto, Antonio; Corsello, Giovanni; Finco, Gabriele; Fanos, Vassilios; Marincola, Flaminia Cesare

doi:10.23736/s0022-4707.20.11200-3

Cited by 22 publications

(25 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Future studies should be designed to test the increase of circulating SCFAs against exercise performance and recovery, as well as the incidence of illness, particularly over periods of susceptibility such as the winter training cycle. Above all, combining in vivo gold-standard clinical techniques with advanced sportomic [190,191], metatranscriptomic and metagenomic approaches will help to better understand the complex rela-tionship and interactions between food intake, the microbiome and host metabolic, gastrointestinal, and 'athletic' health.…”

Section: Discussionmentioning

confidence: 99%

The Athlete and Gut Microbiome: Short-chain Fatty Acids as Potential Ergogenic Aids for Exercise and Training

2021

Self Cite

View full text Add to dashboard Cite

Short-chain fatty acids (SCFAs) are metabolites produced in the gut via microbial fermentation of dietary fibers referred to as microbiota-accessible carbohydrates (MACs). Acetate, propionate, and butyrate have been observed to regulate host dietary nutrient metabolism, energy balance, and local and systemic immune functions. In vitro and in vivo experiments have shown links between the presence of bacteria-derived SCFAs and host health through the blunting of inflammatory processes, as well as purported protection from the development of illness associated with respiratory infections. This bank of evidence suggests that SCFAs could be beneficial to enhance the athlete’s immunity, as well as act to improve exercise recovery via anti-inflammatory activity and to provide additional energy substrates for exercise performance. However, the mechanistic basis and applied evidence for these relationships in humans have yet to be fully established. In this narrative review, we explore the existing knowledge of SCFA synthesis and the functional importance of the gut microbiome composition to induce SCFA production. Further, changes in gut microbiota associated with exercise and various dietary MACs are described. Finally, we provide suggestions for future research and practical applications, including how these metabolites could be manipulated through dietary fiber intake to optimize immunity and energy metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

The Athlete and Gut Microbiome: Short-chain Fatty Acids as Potential Ergogenic Aids for Exercise and Training

2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, many studies have investigated the role of butyrate in inflammation, in particular it produces an anti-inflammatory effect in several tissues [27]. However, to date, and as far as we know, the only data reported on sport and butyrate is a recent study by Pintus, in which urinary butyric acid concentration is associated with the type of physical exercise [28]. We identified an increase in urea and lactic acid levels in plasma from athletes.…”

Section: Metabolomic Profilementioning

confidence: 75%

Redox Homeostasis and Metabolic Profile in Young Female Basketball Players during in-Season Training

et al. 2021

View full text Add to dashboard Cite

Background: Most studies on oxidative stress markers and antioxidant levels have been conducted in male athletes, although female participation in sport has increased rapidly in the past few decades. In particular, it could be important to assess oxidative stress markers in relation to the training load because the anaerobic path becomes predominant in high-intensity actions. Methods: Ten female professional basketball players, performing five 2 h-lasting training sessions per week, and 10 sedentary control women were investigated. Capillary blood and saliva samples were collected in the morning before the training session. The antioxidant capacity and the levels of reactive oxygen metabolites on plasma were determined measuring Reactive Oxygen Metabolite and Biological Antioxidant Potential (d-ROMs and the BAP Test). Salivary cortisol was detected by using commercial enzyme-linked immunosorbent assay kit. Results: The antioxidant capacity (BAP value) was significantly higher in elite basketball players (21.2%; p < 0.05). Conversely, cortisol (51%; p < 0.009) and the levels of oxidative species (d-ROM, 21.9%; p < 0.05) showed a significant decrease in elite athletes.

show abstract

“…In fact, few, if any at all, relation has been made linking this compound with human diseases, possibly due to the large fluctuation in normal-functioning human body as one bioavailability study described its metabolic generation from food polyphenols 36 . Hippuric acid, on the other hand, is very much like TMAO in its dietary origin and relation to microbiota 37 , and its synthesis has been applied clinically as a measurement of liver’s detoxication ability. Its down-regulation (fold change of 5.31) in ER stress phenotype therefore suggested the lowering in hepatic functions and consequently linked liver damage with ER stress.…”

Section: Discussionmentioning

confidence: 99%

Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung

Wang

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Endoplasmic reticulum (ER) stress is a cellular state that results from the overload of unfolded/misfolded protein in the ER that, if not resolved properly, can lead to cell death. Both acute lung infections and chronic lung diseases have been found related to ER stress. Yet no study has been presented integrating metabolomic and transcriptomic data from total lung in interpreting the pathogenic state of ER stress. Total mouse lungs were used to perform LC–MS and RNA sequencing in relevance to ER stress. Untargeted metabolomics revealed 16 metabolites of aberrant levels with statistical significance while transcriptomics revealed 1593 genes abnormally expressed. Enrichment results demonstrated the injury ER stress inflicted upon lung through the alteration of multiple critical pathways involving energy expenditure, signal transduction, and redox homeostasis. Ultimately, we have presented p-cresol sulfate (PCS) and trimethylamine N-oxide (TMAO) as two potential ER stress biomarkers. Glutathione metabolism stood out in both omics as a notably altered pathway that believed to take important roles in maintaining the redox homeostasis in the cells critical for the development and relief of ER stress, in consistence with the existing reports.

show abstract

Sportomics in professional soccer players: metabolomics results during preseason

Cited by 22 publications

References 24 publications

The Athlete and Gut Microbiome: Short-chain Fatty Acids as Potential Ergogenic Aids for Exercise and Training

The Athlete and Gut Microbiome: Short-chain Fatty Acids as Potential Ergogenic Aids for Exercise and Training

Redox Homeostasis and Metabolic Profile in Young Female Basketball Players during in-Season Training

Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung

Contact Info

Product

Resources

About