Spray dried solid dispersion of repaglinide using hypromellose acetate succinate: <i>in vitro</i> and <i>in vivo</i> characterization

Surti, Naazneen; Mahajan, Arpana; Patel, Dhruvi; Patel, Ashwini; Surti, Zubiya

doi:10.1080/03639045.2020.1812631

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…Many methods have been reported to increase the solubility of curcumin and promote its bioavailability. Relative techniques include the preparation of colloids, proteinbased complexes, solid dispersions, nanoemulsions [6][7][8], and so forth. However, most of these methods have complex processes and poor physical stability and many risks such as drug leakage and potential toxicity of excipients and reagents [6], which limits the clinical application.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials

Zheng

Wang

Xiang

et al. 2021

Bioinorganic Chemistry and Applications

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In order to achieve the controlled release of curcumin, HPMC (hydroxypropyl methyl cellulose) was spray dried with curcumin and lactose. The spray-dried materials were pressed into tablets with a diameter of 8 mm, and their release characteristics in vitro were measured. In vitro experiments showed that the release of curcumin from the HPMC mixture was significantly slower due to the sustained-release property of HPMC as a typical excipient. The release profile of curcumin from the HPMC mixture was relatively stable for a controlled release. SEM images show that the HPMC co-spray-dried powders have crumpled surfaces due to the large molecular weight of HPMC. DSC, XRD, FTIR, N2 adsorption, and TGA have been measured for the spray-dried curcumin materials. This work indicates that HPMC can be used as a controlled-release excipient for curcumin preparations.

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Section: Introductionmentioning

confidence: 99%

Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials

Zheng

Wang

Xiang

et al. 2021

Bioinorganic Chemistry and Applications

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“…API in spray-dried form increases the solubility by increasing surface area and porosity 4,5 . Psychosis is a state of mind where an individual experiences things that no one else experiences, an impaired relationship with reality.…”

Section: Introductionmentioning

confidence: 99%

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2023

IJPSR

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Aripiprazole is a biopharmaceutics classification system (BCS) II drug used to treat schizophrenia and bipolar disorders. A fast-dissolving tablet will be an appropriate drug delivery route in these conditions. Therefore, the objective of the work was to convert aripiprazole into a solid dispersion via a spray drying process and further present it as an oral fast-dissolving tablet for improving patient compliance. The solid dispersion of the drug in mannitol from solvent evaporation via spray-drying forms porous amorphous solid dispersions. The spray drying trials were optimized using a custom design approach via Design Expert software version 13. Oral fast-disintegrating tablets containing optimized solid dispersions were evaluated for tableting properties, in-vitro drug release profile, and pharmacokinetic profile compared to aripiprazole. The optimized solid dispersion exhibited a 2-fold increase in solubility compared to pure aripiprazole. The tablet disintegrated in 27.1± 1.1seconds. The in-vitro drug dissolution showed a four-fold increase in drug release profile compared to pure aripiprazole in one h. The pharmacokinetic profile observed a two-fold increase in the bioavailability of solid dispersion in comparison to the pure drug suspension. The stability studies for six months assured the stability of the tablet. In conclusion, an orally disintegrating tablet of aripiprazole with improved solubility may increase the therapeutic efficacy of the drug.

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A novel Posaconazole oral formulation using spray dried solid dispersion technology: in-vitro and in-vivo study

Patel,

Kevlani,

Shah

2023

Drug Deliv. and Transl. Res.

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Spray dried solid dispersion of repaglinide using hypromellose acetate succinate: in vitro and in vivo characterization

Cited by 8 publications

References 26 publications

Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials

Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials

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A novel Posaconazole oral formulation using spray dried solid dispersion technology: in-vitro and in-vivo study

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