Sprouting of CGRP nerve fibers in response to dentin injury in rat molars

Immunoelectron Microscopic Observation of Calcitonin Gene-Related Peptide(CGRP)-positive Nerves in the Dental Pulp of Rat Molars.

“…Accordingly, immunohistochemistry for CGRP has been applied to investigate the neurophysiology of dental pulp, and suggested a possible role of CGRP as a vasoregulator in the dental pulp (UDDMAN et al, 1986;WAKISAKA et al, 1987). Further, dynamic responses of CGRP-immunoreactive nerve fibers to external stimuli including dentinal injury have been demonstrated, suggesting CGRP involvement in tissue repair as well as in sensory and/or vascular regulation KHAYAT et al, 1988;TAYLOR et al, 1988;BYERS et al, 1990 …”

Different Localizations of Growth-Associated Protein (GAP-43) in Mechanoreceptors and Free Nerve Endings of Adult Rat Periodontal Ligament, Dental Pulp and Skin.

“…Further investigations are needed to clarify the functional siginificance of GAP-43 in the periodontal ligament. (1992). HEYERAAS, K. J., I. KVINNSLAND, M. R. BYERS and E. B.…”

“…Some experimental studies on cavity preparation and pulpitis (YAMAURA, 1987;BYERS et al, 1988;KHAYAT et al, 1988;KIMBERLY and BYERS, 1988;TAYLOR et al, 1988;SATO, 1989) have suggested that the nerve fibers in the dental pulp have high potential for neuroplasticity, though they are enclosed by hard tissues. Furthermore, even in the dental pulp of adult rats, essentially all pulpal and dentinal nerve fibers retain the immunoreactivities for p75-NGFR which have been known to be expressed high levels in developing and regenerating neurons (BYERS, 1990;SATO et al, 1990;MAEDA et al, 1992).…”

“…This environment readily suggests that mechanoreceptive and nociceptive neural elements in the periodontal ligament are capable of dynamic plasticity in response to alterations in their tissue, a process that might very likely utilize GAP-43 protein. Further, some experimental studies also have revealed that the pulpal nerve fibers have high potential for neural plasticity against external stimuli such as cavity preparation and inflammation (YAMAURA, 1987;BYERS et al, 1988;KHAYAT et al, 1988;KIMBERLY and BYERS, 1988;TAYLOR et al, 1988;SATO, 1989).…”

Distribution of Peripherin Immunoreactive Axons in Rat Molar Pulp

“…3C and 3F-III)와 신경얼기 ( CGRP는 주로 염증성 동통전달에 관련된 신경전달물 질로서, 펩타이드성 민말이집 혹은 작은 말이집 축삭 표지자로 많이 사용되며 [8,9], 혈관확장, 대식세포와 백 혈구 조절 등의 면역작용에 관여한다고 알려져 있다 [18,19]. 또한 치수에 염증이 발생하였을 때 CGRP 면역 양성 축삭들은 염증부위에서 급격히 그 수가 증가하는 sprouting 현상을 보임으로써 치수염에 따른 염증성 통 각과민에 깊이 관여하는 물질로 알려져 있으며 [20][21][22], 이러한 sprouting이 이차상아질형성과 재생과정에 관여 할 것이라는 주장도 제시된 바 있다 [22,23] …”