Spur-Cell Anemia

Smith, Jeanne A.; Lonergan, E. T.; Sterling, Kenneth

doi:10.1056/nejm196408202710804

Cited by 124 publications

(14 citation statements)

References 7 publications

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“…Ethanol also appears to have a specific antifolate action [98]. A variety of other red cell changes may occur in association with alcohol dependence, such as sideroblastic anaemia [96,98,100] and, particularly in alcoholic cirrhosis, occurrence of spur cells and stomatocytes [96,98,[100][101][102][103][104]. MCV levels may also become elevated with liver disease of any cause, due to altered synthesis or increased destruction (haemolysis) of red cells in the congested spleen [97].…”

Section: Brief Description and Historymentioning

confidence: 99%

Traditional markers of excessive alcohol use

et al. 2003

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Section: Brief Description and Historymentioning

confidence: 99%

Traditional markers of excessive alcohol use

et al. 2003

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“…Echinocytosis could be related with massive splenic haemangioma (Altomare, Desman, & Aledort, 2006), acanthocytosis with cirrhosis or pancreatitis (Hillman, Ault, Leporrier, & Rinder, 2011) and abetalipoproteinemia (Haldeman-Englert & Zieve, 2011). Depleted ATP levels and defected lipid to protein composition of cell membrane result in tendency to form spikes due to inability to bear surface tension (Sharma, Sharma, Singh, Swami, & Sharma, 2009;Smith, Lonergan, & Sterling, 1964). have explained that the administration of cineole caused significant impact on the rainbow trout health through the elevation of red blood cell (RBC) and…”

Section: Discussionmentioning

confidence: 99%

Augmenting fish health usingEmblica officinalisagainst triarylmethane dye induced blood toxicity inCyprinus carpio

Sinha

Jindal

2019

Aquac Res

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Blood is a sensitive bioindicator of stress observed by organisms in response to toxicants. Erythrocytic morphological abnormalities serve as a reliable determinant of fish health. Malachite green, a multifunctional dye was assessed for toxicity in Cyprinus carpio. Dye‐induced blood toxicity has been determined through biochemical and ultra structural endpoints at 15, 30 and 60 days in the fish. Further, an attempt has been made to combat the adverse effects of the toxicant through supplementation with Emblica officinalis. Electron microscopic study depicted erythrocytic remodelling in form of surface blebbing, lobopodial projections and shrinkage; appearance of crenate, acanthocytes, echinocytes, dacrocytes, spherocytes and rhomboidal cells. Hepatic marker enzymes showed significantly (p < 0.05) elevated levels of biomarker enzymes, alkaline phosphatase, serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase. Contrarily feeding with E. officinalis extract (1,000 mg/kg feed) significantly attenuated biochemical and morphological alterations, indicating the protective efficacy of E. officinalis. Both toxicity and attenuation observed were in exposure‐dependent manner.

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“…Formation of echinocytes is often reversible and can be induced by altering the cell's environment, such as pH of the medium, the metabolic state, and adding chemical substances. Similar to echinocytes, acanthocytes are also characterized by spicules on the cell membrane, but they are irregular in size, shape, and distribution [117,118]. The formation of acanthocytes is attributed to abnormal lipid composition with altered lipid distribution between the inner and outer leaflets of the bilayer membrane.…”

Section: Morphological Change In Diseased Rbcsmentioning

confidence: 99%