Squamous carcinoma of the tongue: review

Prince, Samantha; Bailey, B.M.W.

doi:10.1054/bjom.1999.0031

Cited by 99 publications

(68 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Oral squamous cell carcinoma (SCC) is a major neoplasm of the oral cavity with an increasing rate of incidence (1)(2)(3). The optimal therapy for early oral SCC is surgery, but the overall survival rate has exhibited only a slight change (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma

et al. 2014

View full text Add to dashboard Cite

Abstract. Fatty acid binding proteins (FABPs) are a family of small and highly conserved lipid chaperone molecules with highly varied functions. Among them, fatty acid binding protein 4 (FABP4, also known as aP2) is highly expressed by adipocytes, macrophages and dendritic cells. Although the role of FABP4 in cancer is still unclear, it has been reported to be highly expressed by human tumors such as ovarian and bladder cancers. In the present study, we investigated the expression and role of FABP4 in oral squamous cell carcinoma (SCC) and its expression in oral SCC tissues. Immunohistochemical staining revealed that FABP4 expression in the tumor tissue was much higher than that in the non-tumor area of the same specimen. In the in vitro studies, an FABP4-knockdown SCC cell line (established through FABP4-specific siRNA) showed inhibited growth, and inhibited expression and activation of mitogen-activated protein kinase (MAPK). These results indicate that expression of FABP4 plays an important role in the cell growth of oral SCC through the MAPK pathway. IntroductionOral squamous cell carcinoma (SCC) is a major neoplasm of the oral cavity with an increasing rate of incidence (1-3). The optimal therapy for early oral SCC is surgery, but the overall survival rate has exhibited only a slight change (1-3). Therefore, more effective therapies for oral SCC are needed.Fatty acid binding proteins (FABPs) are a family of small and highly conserved lipid chaperone molecules that bind long-chain fatty acids and other hydrophobic ligands. Their functions are wide ranging (4-6). Among them, fatty acid binding protein 4 (FABP4, also known as aP2) is highly expressed in adipocytes, macrophages and dendritic cells (5,7). As a result of its distribution, FABP4 is the most extensively researched FABP in endocrinology and metabolomics. FABP4 affects metabolic syndrome progression; FABP4-deficient mice were found to have reduced hyperinsulinemia and insulin resistance in obesity (7,8) and showed protection from atherosclerosis (9).However, little is known concerning the role of FABP4 in cancer, including oral SCC. Recently, Nieman et al (10) reported that adipocytes promote ovarian cancer metastasis and tumor cell growth by providing energy mediated by FABP4. Therefore, increased FABP4 expression may affect the growth of various tumor types. Our research group also reported that molecules controlled by peroxisome proliferator-activated receptor γ (PPARγ) play key roles in SCC growth (11-15). As FABP4 is known to mediate transcription with PPARγ (4,16), we hypothesized that FABP4 may regulate SCC growth. Therefore, in the present study, we investigated FABP4 expression and its effects on SCC of the tongue. Materials and methodsTissue samples. All clinical studies were approved by the Ethics Committee of Osaka University Dental Hospital, Osaka. Twenty-seven SCC specimens from resected tongue tissue were obtained at the Osaka University Dental Hospital during 1986-2008 after patient informed consent (Table I). Patients received no pre...

show abstract

Section: Introductionmentioning

confidence: 99%

“…The optimal therapy for early oral SCC is surgery, but the overall survival rate has exhibited only a slight change (1)(2)(3). Therefore, more effective therapies for oral SCC are needed.…”

Section: Introductionmentioning

confidence: 99%

Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The optimal treatment or therapy for early carcinoma of the tongue remains a controversial issue and surgical operation is still an effective therapy for squamous cell carcinoma in the field of maxillofacial surgery. However, the recovery of lost function after a large surgical excision is accompanied by many problems such as speech impediment and dysphagia (1). Local-regional control of head and neck cancer has improved in recent decades.…”

mentioning

confidence: 99%

Critical Role of Peroxisome Proliferator-Activated Receptor γ on Anoikis and Invasion of Squamous Cell Carcinoma

Masuda

Wada

Nakajima

et al. 2005

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose: Peroxisome proliferator-activated receptor g (PPARg) plays a important role in various physiological functions.We examined whether PPARg is expressed in primary squamous cell carcinoma and lymph node metastasis and whether PPARg is a potential target for tumor therapy. Experimental Design and Results: A high-level expression of PPARg was observed in tumor cells of human primary squamous cell carcinoma, lymph node metastasis, and squamous cell carcinoma cell lines. Treatment with PPARg-specific antagonists, but not agonists, caused apoptotic cell death on squamous cell carcinoma cell lines in a concentration-dependent manner. Small interfering RNA for PPARg also inhibited cell adhesion and growth of squamous cell carcinomas. The phosphorylation of focal adhesion kinase (FAK) was decreased by treatment with PPARg antagonists, and resulted in decreases in phosphorylation of Erk and mitogen-activated protein kinase. Furthermore, PPARg antagonists decreased the adhesion of squamous cell carcinomas into fibronectin-coated plates, indicating the inhibition of interaction between squamous cell carcinomas and fibronectin. Expression of integrin a5, a counter adhesion molecule for fibronectin, was inhibited by the treatment with PPARg antagonists.These results indicate that the decrease in integrin a5 and following inhibition of cell adhesion may cause the inhibition of FAK signaling pathways. PPARg antagonists also strongly inhibited invasion of squamous cell carcinoma via down-regulation of CD151expression. Conclusions: The cell death caused by the PPARg antagonists was a result of direct interference with cell adhesion ''anoikis'' involving intracellular FAK signaling pathways. These results imply a potentially important and novel role for the inhibition of PPARg function via the use of specific antagonists in the treatment of squamous cell carcinoma and the prevention of tumor invasion and metastasis.

show abstract

“…The long-term prognosis of newly diagnosed SCC remains poor, with an overall 5-year survival rate of only 50% (Prince and Bailey, 1999). Much of the morbidity and mortality associated with oral cancer can be prevented or limited by early detection.…”

mentioning

confidence: 99%

“…The tongue was the examined area, since it is the most common site of oral carcinoma (Prince and Bailey, 1999). To further assess the phenomenon of immune cell infiltration in tumours of epithelial origin, we also examined the infiltrate profile in Pleomorphic Adenomas (PA) in the parotid gland.…”

mentioning

confidence: 99%

Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma

Gannot

Vered

et al. 2002

Br J Cancer

View full text Add to dashboard Cite

In the present study, epithelium derived lesions of various pathological manifestations were examined histologically and immunohistochemically for mononuclear cell infiltration. The infiltrate under the transformed epithelium of oral lesions, was examined for differences in the composition of immune mononuclear cells as the epithelium moves from hyperkeratosis through various degrees of dysplasia to squamous cell carcinoma. The study was performed on 53 human tongue tissues diagnosed as hyperkeratosis (11 cases), mild dysplasia (nine cases), moderate and severe dysplasia (14 cases) and squamous cell carcinoma (19 cases). A similar analysis was performed on 30 parotid gland tissues diagnosed as pleomorphic adenoma (14 cases) and carcinoma ex-pleomorphic adenoma (16 cases). Immunohistochemical analysis of various surface markers of the tumour infiltrating immune cells was performed and correlated with the transformation level as defined by morphology and the expression of p53 in the epithelium. The results revealed that, in the tongue lesions, the changes in the epithelium from normal appearance to transformed were accompanied by a corresponding increase in the infiltration of CD4, CD8, CD14, CD19+20, and HLA/DR positive cells. The most significant change was an increase in B lymphocytes in tongue lesions, that was in accordance with the transformation level (P50.001). In the salivary gland, a significant number of cases did not show an infiltrate. In cases where an infiltrate was present, a similar pattern was observed and the more malignant tissues exhibited a higher degree of immune cell infiltration.

show abstract

Squamous carcinoma of the tongue: review

Cited by 99 publications

References 100 publications

Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma

Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma

Critical Role of Peroxisome Proliferator-Activated Receptor γ on Anoikis and Invasion of Squamous Cell Carcinoma

Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma

Contact Info

Product

Resources

About