Squamous Cell Carcinoma Arising in a Verrucous Epidermal Nevus

Ichikawa, Takanori; Saiki, Megumi; Kaneko, Mamoru; Saida, Toshiaki

doi:10.1159/000246229

Cited by 28 publications

(19 citation statements)

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“…To the best of our knowledge, only 12 cases of CSCC arising from verrucous epidermal nevi have been reported so far in the literature. Nine cases are displayed in table 1 [7, 12, 13, 14, 15, 16, 17, 18, 19], while the data in the remaining 3 cases were inadequate: 2/3 cases were described in poster abstracts [20, 21], and the third case was not available as a full text [22]. …”

Section: Discussionmentioning

confidence: 99%

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus

et al. 2013

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A malignant transformation is known to occur in many nevi such as a sebaceous nevus or a basal cell nevus, but a verrucous epidermal nevus has only rarely been associated with neoplastic changes. Keratoacanthoma, multifocal papillary apocrine adenoma, multiple malignant eccrine poroma, basal cell carcinoma and cutaneous squamous cell carcinoma (CSCC) have all been reported to develop from a verrucous epidermal nevus. CSCC has also been reported to arise from other nevoid lesions like a nevus comedonicus, porokeratosis, a sebaceous nevus, an oral sponge nevus and an ichthyosiform nevus with CHILD syndrome. Here we report a case of progressive poorly differentiated CSCC arising from a localized verrucous epidermal nevus, which caused both spinal cord and brain metastasis.

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Section: Discussionmentioning

confidence: 99%

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus

et al. 2013

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“…Ichikawa et al [21] reported 16 cases of linear epidermal nevi associated with malignant change (BCC, SCC, Bowen's disease, verrucous carcinoma, adnexal carcinoma). In some cases, exposure to physical agents (ultraviolet light and chemical carcinogens) was found to be a predisposing factor.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory linear verrucous epidermal nevus syndrome with its polymorphic presentation - A rare case report

2012

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Epidermal nevi are hamartomatous lesions that are typically present at birth, but can occur anytime during childhood and may rarely appear in adulthood. An estimated one-third of individuals with epidermal nevi have involvement of other organ systems; hence, this condition is considered to be an epidermal nevus syndrome. There are four distinct epidermal nevus syndromes recognizable by the different types of associated epithelial nevi: linear sebaceous nevi, linear nevus comedonicus, linear epidermal nevus, and inflammatory linear verrucous epidermal nevus (ILVEN). Each type may be regarded as a part of a syndrome with other systemic manifestations. We report a rare case of ILVEN syndrome in a 23-year-old female patient with a wide spectrum of mucosal, cutaneous, and skeletal abnormalities, demonstrating the polymorphic presentation of this condition.

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“…Some Authors [5,6] have reported that a mild chronic inflammatory infiltrate can be present in the lamina propria. Regarding a possible neoplastic transformation of LEN it is of interest to mention that basal and squamous cell carcinoma, verrucous carcinoma and adnexal carcinoma arised from cutaneous LEN have been reported but, to date, no cases of malignant transformation of oral LEN have been reported [18].…”

Section: Discussionmentioning

confidence: 99%

Oral Linear Epidermal Nevus: A Review of the Literature and Report of Two New Cases

Tesi

Ficarra

2010

Head and Neck Pathol

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Linear epidermal nevus (LEN) is a sporadic hamartomatous lesion of the skin due to the proliferation of clones of embryonic ectodermal cells, which are arranged according to a typical linear configuration known as Blaschko's lines. Oral involvement of LEN is very rare and few cases have been reported in the medical literature. We report two new cases of LEN with exclusive oral involvement, which presented with the typical unilateral or midline distribution. Oral LEN presents as an exophytic lesion with well defined borders and a verrucous or papillary surface which correspond, histologically, to epithelial papillomatosis with a moderate degree of hyperkeratosis and acanthosis. Oral LEN appears mainly at birth, grows slowly during childhood and stabilize by adolescence. Localized lesions do not show any recurrence after surgical removal but widespread lesions seem to have more risk of recurrence and are more difficult to manage. Functional problems and malignant transformation have not been reported.

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Squamous Cell Carcinoma Arising in a Verrucous Epidermal Nevus

Cited by 28 publications

References 0 publications

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus

Fatal Metastatic Cutaneous Squamous Cell Carcinoma Evolving from a Localized Verrucous Epidermal Nevus

Inflammatory linear verrucous epidermal nevus syndrome with its polymorphic presentation - A rare case report

Oral Linear Epidermal Nevus: A Review of the Literature and Report of Two New Cases

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