Squamous cell carcinoma in mature cystic teratoma of the ovary

Amidzic, Jelena; Djolai, Matilda; Mocko-Kacanski, Mihaela; Gluhovic, Aleksandar; Ilić, Jelena D.; Božanić, Snežana

doi:10.2298/mpns1210429a

Cited by 3 publications

(3 citation statements)

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“…CT scan of abdomen showed a large bilobed cystic lesion with fat-fluid level and solid calcified structure (teeth) protruding into the cyst cavity [Rokitansky protuberance]. The lesion was displacing the contrast filled bowel loops in most of the cases 5,6 .…”

Section: Disscusionmentioning

confidence: 99%

“…Cytogenetic abnormalities might precede histological changes and prolonged exposure to various carcinogens in the pelvic cavity might cause the malignant changes in mature tissue. Risk factors for malignancy in MCT include patient age,tumor size and imaging characteristics.Tumor size greater than 10cm should raise the suspicion of malignancy.In our case,the tumor diameter was 15 cm,which corresponds to literature.It is postulated that the larger size of ovarian mass indicates long standing disease process and likelihood of any of the components becoming malignant is higher 5,6 .…”

Section: Disscusionmentioning

confidence: 99%

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Study of Histomorphological Changes of Teratomas in Tertiary Care Hospital.

A¹,

K²,

S³

et al. 2013

jemds

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Teratomas are the germ cell tumors composed of multiple cell types derived from one or more of the three germ layers.Teratomas range from benign well differentiated [mature] cystic lesions to those that are solid and malignant [immature].Additionally, teratomas may be monodermal and highly specialized. Rarely, within some mature teratomas, certain elements like squamous component undergo malignant transformation.Teratomas are known to occur at birth and are derived from pleuripotent germ cells and embryonic cells. Teratomas of embryonic origin are congenital and are seen in the midline of the body-skull, neck, mediastinum, retroperitoneum, and coccyx.Teratomas derived from the germ cells are seen in testis in men and ovaries in women. AIMS: This prospective and retrospective study was conducted to determine the frequency of the teratomas occurring in various sites along with their histomorphological presentations. MATERIALS AND METHODS: The study was conducted at Rajarajeswari Medical College and Hospital between January 2010 to December 2012 in the Department of Pathology. Morphological and histopathological features of teratomas were studied. RESULTS: Teratomas were more common in females between 25-35yrs.Most of the teratomas were seen in ovaries followed by retroperitoneum and sacrococcygeal region.87% of teratomas diagnosed were of mature cystic teratoma with histologic grading 0 and remaining 13% showed malignant transformation. CONCLUSION: Mature teratomas are typically benign and found more frequently in women and there is risk of malignant transformation.

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Section: Disscusionmentioning

confidence: 99%

Section: Disscusionmentioning

confidence: 99%

Study of Histomorphological Changes of Teratomas in Tertiary Care Hospital.

A¹,

K²,

S³

et al. 2013

jemds

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“…It has been reported that only 2% of the cases diagnosed with mature cystic teratoma undergo a malignant change [1]. 75% of these cases with this type of germ cell tumor are further diagnosed to have squamous cell carcinoma [2]. The survival rate in these cases is around 15 to 30% over a period of 5 years [3].…”

Section: Introductionmentioning

confidence: 99%

Malignancy in mature cystic teratoma of the ovary: A rarity

Das¹,

Medical²,

Panda³

et al. 2017

Obs Gyne Reivew J Obstet Gynecol

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Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Zhang

et al. 2019

BMC Cancer

134

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Background0.17–2% of mature cystic teratoma of the ovary (MCTO) undergo malignant transformation, of which 80% are squamous cell carcinoma (SCC) transformation in MCTO. We aim to investigate the clinical characteristics and treatment of SCC transformation in MCTOMethodsWe systematically searched PubMed database and individual patient data about SCC transformation in MCTO were extracted. The published cases were combined with 6 cases of SCC transformation in MCTO from Qilu Hospital, Shandong University.ResultsThe incidence of SCC transformation in MCTO was 0.3%. A total of 435 cases of SCC transformation in MCTO were enrolled in the analysis. The mean age of diagnosis was 53.5 (range 19–87) years old. The most common clinical manifestations were abdominal pain (47.3%) and abdominal mass (26.0%). StageI,II, III and IV accounted for 50.0, 18.8, 26.8 and 4.4% of all cases, respectively. Patients with stage I had significantly better prognosis than stage II, III and IV patients (P < 0.01). Hysterectomy can improve overall survival (P < 0.01). For patients younger than 45 years old with stageIA orIC, there was no difference in mortality between fertility-sparing and radical surgery (P = 1.00). Adjuvant chemotherapy can improve survival in patients with advanced stage (P = 0.02), and chemotherapy with platinum was related to better prognosis (P = 0.02).ConclusionSCC transformation in MCTO is a rare malignancy mainly occurs in older age. FIGO stage is an independent prognostic factor. Hysterectomy and platinum-based chemotherapy are associated with better survival. Fertility-sparing surgery is feasible for young patients with early stage.Electronic supplementary materialThe online version of this article (10.1186/s12885-019-5393-y) contains supplementary material, which is available to authorized users.

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Squamous cell carcinoma in mature cystic teratoma of the ovary

Abstract: Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

Cited by 3 publications

References 4 publications

Study of Histomorphological Changes of Teratomas in Tertiary Care Hospital.

Study of Histomorphological Changes of Teratomas in Tertiary Care Hospital.

Malignancy in mature cystic teratoma of the ovary: A rarity

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

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