Squamous cell carcinoma with cyst of the thyroid

Abstract

Two cases of primary squamous cell carcinoma associated with a thyroid cyst in the thyroid are described. The majority of squamous cell carcinomas reported so far have had some degree of co-existing adenocarcinoma, while the cases presented in this report had no glandular component at all. The histogenesis of squamous cell carcinoma is not clear, but at present, it is believed that most cases arise from the follicular epithelium. In our cases, in spite of an intensive examination of serially sectioned specimens, no areas of adenocarcinoma, squamous metaplasia from the follicular epithelium, or congenital squamous remnants could be found.

Primary squamous cell carcinoma of the thyroid: Case report and systematic review of the literature

“…of the esophagus or the pharynx as well as larynx, are usually treated by radiotherapy [57]. Though, some reports declared squamous cell carcinoma of the thyroid to be radioresistant [3], [34]. Our data show, that disease free survival greater 12 months was only achieved in seven patients with an early tumor stage without lymph node involvement, complete surgical resection in combination with additional radiotherapy and/or chemotherapy.…”

“…Some 17 publications with 48 cases without complete work-up, including CT-scan, panendoscopy, immunohistochemistry and double citations were excluded [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]. Finally, 35 papers and ours reporting on 50 patients were available for analysis [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58].

Fig. 2The flow chart of identified studies.

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Primary squamous carcinoma of the thyroid–a case report

“…Focal metaplastic squamous differentiation has been reported to occur in 40 per cent of papillary and mixed papillary/ follicular carcinomas (Segal et al, 1984). In fact, most cases of squamous carcinoma of the thyroid in the literature have showed some degree of adenocarcinomatous differentiation (Harada et al, 1989). Furthermore, local invasion from surrounding structures and/or metastasis is far more common than primary squamous carcinoma and this mandates a thorough search for a primary tumour elsewhere (Segal et al, 1984;Korovin et al, 1989).…”

Primary squamous cell carcinoma of the thyroid gland: an entity with aggressive clinical behaviour and distinctive cytokeratin expression profiles

“…To date, approximately 130 cases of primary squamous cell carcinoma of the thyroid gland have been reported in the English literature, with the majority being case reports 7–34 . Thus, clinicopathological features of primary squamous cell carcinoma of the thyroid gland are not well defined.…”