Stability-indicating HPTLC determination of curcumin in bulk drug and pharmaceutical formulations

Ansari, Mohammad Javed; Ahmad, Sayeed; Kohli, Kanchan; Ali, Javed; Khar, Roop K.

doi:10.1016/j.jpba.2005.03.021

Cited by 156 publications

(79 citation statements)

References 19 publications

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“…•--mediated reactions as described in and Winterbourn and Kettle (2003), in all probability constitute the starting conditions from which curcumin is chemically degraded (Tønnesen et al, 1986;Ansari et al, 2005) or modified via pathways as proposed by, e.g., Tønnesen and Greenhill (1992), Masuda et al (1999Masuda et al ( , 2002, Fujisawa et al (2004), Agnihotri andMishra (2011), andGriesser et al (2011). These reactions also account for the formation of C-centered radicals as observed by Chignell et al (1994) during irradiation of dissolved curcumin.…”

Section: •-mentioning

confidence: 90%

“…The degradation rate constants (k deg ) of 40 mM curcumin dissolved in different organic solvents and exposed for 4 hours to visible light (400-750 nm) conform to first-order kinetics and constitute k deg = (Tønnesen et al, 1986). Visible light imposes a broader degree of degradation than UV light inasmuch as irradiation of curcumin in methanol with 254-nm light produced three unspecified degradation Cancer Pharmacology of Curcumin products, whereas irradiation with daylight produced five unspecified degradation products (Ansari et al, 2005), indicating that some of the degradative reactions require the first excited or triplet state induced through the violet absorption band ("Mechanisms of photo-induced reactive oxygen species production by curcumin and photochemical degradation/modification of dissolved curcumin," section II.C.1.a.ii).…”

mentioning

confidence: 96%

“…Curcumin is a chromophore that absorbs strongly in the visible wavelength range, making it susceptible to photo(oxidative) degradation and modification in daylight and artificial lighting. Photo-induced degradation of curcumin occurs irrespectively of the chemical environment, i.e., in solid state as well as in different organic solvents (Tønnesen et al, 1986;Khurana and Ho, 1988;Ansari et al, 2005), even in the absence of UV light and oxygen (Tønnesen et al, 1986). However, the composition, degradation kinetics, and relative abundance of the degradation products differ depending on the physical state of the compound and the conditions.…”

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confidence: 99%

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The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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Section: •-mentioning

confidence: 90%

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confidence: 96%

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confidence: 99%

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The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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“…4), suggesting thermal and oxidative degradation of the curcumin, as previously reported. 26,27) To solve the problems, the careful selection of optimal printing temperature is important and would prevent the drug degradation in PVA filament which was prepared by soaking methods.…”

Section: Effect Of 3d-printing Conditions On the Formabilitymentioning

confidence: 99%

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

Tagami

Fukushige

Ogawa

et al. 2017

Biological & Pharmaceutical Bulletin

118

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Three-dimensional (3D) printers have been applied in many fields, including engineering and the medical sciences. In the pharmaceutical field, approval of the first 3D-printed tablet by the U.S. Food and Drug Administration in 2015 has attracted interest in the manufacture of tablets and drugs by 3D printing techniques as a means of delivering tailor-made drugs in the future. In current study, polyvinylalcohol (PVA)-based tablets were prepared using a fused-deposition-modeling-type 3D printer and the effect of 3D printing conditions on tablet production was investigated. Curcumin, a model drug/fluorescent marker, was loaded into PVA-filament. We found that several printing parameters, such as the rate of extruding PVA (flow rate), can affect the formability of the resulting PVA-tablets. The 3D-printing temperature is controlled by heating the print nozzle and was shown to affect the color of the tablets and their curcumin content. PVA-based infilled tablets with different densities were prepared by changing the fill density as a printing parameter. Tablets with lower fill density floated in an aqueous solution and their curcumin content tended to dissolve faster. These findings will be useful in developing drug-loaded PVA-based 3D objects and other polymerbased articles prepared using fused-deposition-modeling-type 3D printers. Key words three-dimensional (3D) printing; fused deposition modeling; polyvinylalcohol (PVA); tablet; curcuminThe production of various objects by three-dimensional (3D) printers has developed extensively as the printers have evolved.1,2) 3D printers are used by the creator to rapidly design prototype parts and can thus considerably cut production times and costs. 3D printers have been used to manufacture parts for cars, home electronic devices, aircraft engines, buildings, and for other practical uses. It is speculated that 3D printers have potential for many applications and that the 3D printer market will expand.The medical applications of 3D printers have been expanding and bringing innovation to the field.3) For example, the 3D printing of organs and body parts is used to provide blueprints 4) for surgeons and patients to understand disease sites.5-7) In addition, bioprinting, which involves the placement of cells, proteins and genes on a substrate, is also being conducted in the anticipation of future applications in tissue engineering.8,9) Future artificial organs and implantable devices are also being designed. 10,11) In the pharmaceutical industry, a new tablet (SPRITAM ® , a rapid disintegrating tablet containing levetiracetam) prepared by 3D printing was approved by the U.S. Food and Drug Administration (FDA) in 2015.12) The application of 3D printing in medicine, including tablets, holds promise for made-to-order drugs and removes mass product manufacturing from the production line, although the technology in pharmaceutical industry is still in infancy.13) Moreover, it is predicted that the internet of things (IoT) will increase the future use of 3D printers by reinforcing man...

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“…Quantification of CMN has been done by HPTLC technique [28] . Another stability indicating HPTLC method has been developed to quantify CMN in pharmaceutical formulations [29] . A HPLC method for simultaneous determination of CMN and silymarin in various dosage forms has also been reported.…”

Section: Research Papermentioning

confidence: 99%

HPLC and HPTLC methods for Simultaneous Estimation of Quercetin and Curcumin in Polyherbal Formulation

Baghel¹,

Nagar²,

Pannu³

et al. 2017

Journal of Pharmaceutical Sciences

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Baghel, et al.: Chromatographic Analysis of Quercetin and CurcuminFast, sensitive, precise and selective high performance liquid chromatography and high performance thin layer chromatography methods were developed for the simultaneous estimation of curcumin and quercetin in a polyherbal formulation. Validation of these methods were carried out with respect to linearity, range, precision, accuracy and robustness. Both methods were applied to a polyherbal formulation to find the amount of curcumin and quercetin and compared. Curcumin and quercetin were found to be 9.5 mg and 0.613 mg in the polyherbal formulation using the high-performance liquid chromatography method whereas with the high performance thin layer chromatography method, curcumin and quercetin were found to be 9.7 mg and 0.674 mg, respectively. Both methods identified and quantified curcumin and quercetin effectively.

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Stability-indicating HPTLC determination of curcumin in bulk drug and pharmaceutical formulations

Cited by 156 publications

References 19 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

HPLC and HPTLC methods for Simultaneous Estimation of Quercetin and Curcumin in Polyherbal Formulation

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