Stability of Inclusion Complexes of Cyclodextrins with Guaiazulene

Yonezawa, Yasuo; Maruyama, Shigekazu; Takagi, Kaname

doi:10.1080/00021369.1981.10864541

Cited by 3 publications

(1 citation statement)

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“…The formation of complexes may enhance the chemical and thermal stability of these compounds [ 20 ]. The molecule, included in the complex, is protected by the macromolecule against a harmful influence of varied external factors such as high temperature or UV radiation [ 20 , 21 ]. Cyclodextrins can be successfully used in complexing medicines [ 22 , 23 ] and other biologically active compounds [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Studies of the Formation and Stability of Ezetimibe-Cyclodextrin Inclusion Complexes

Biernacka

Ilyich

Заводник

et al. 2021

IJMS

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In the presented studies, the interactions between ezetimibe (EZE) and selected cyclodextrins were investigated. α-Cyclodextrin (αCD), β-cyclodextrin (βCD) and its modified derivatives, hydroxypropyl-β-cyclodextrin (HPβCD) and sulfobutylether-β-cyclodextrin (SBEβCD), were selected for the research. Measurements were carried out using calorimetric and spectroscopic methods. Additionally, the Hirshfeld surface and biochemical analysis were achieved. As a result of the study, the inclusion complexes with 1:1 stoichiometry were obtained. The most stable are the complexes of β-cyclodextrin and its derivatives. The comparison of βCD with its derivatives shows that the modifications have an affect on the formation of more durable and stable complexes.

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Section: Introductionmentioning

confidence: 99%

Studies of the Formation and Stability of Ezetimibe-Cyclodextrin Inclusion Complexes

Biernacka

Ilyich

Заводник

et al. 2021

IJMS

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Cyclodextrins, Their Value in Pharmaceutical Technology

Duchêne

Vaution

Glomot

1986

Drug Development and Industrial Pharmacy

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Cyclodextrins a r e cyclic oligosaccharides consisting of i3 variable number of glucose units (usually 6 to 81.Thje ring formed by cyclodextrins is externally v e r y hydrophilic and relatively apolar internally .In liquid o r solid medium, these mlollecules a r e capable of forming inclusion compounds with many o t h e r molecules. The inclusion compdunds t h u s formed display interesting propertiesin comparison witlh the s t a r t i n g molecule.

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