Stability of lysozyme incorporated into electrospun fibrous mats for wound healing

Liu, Xiaoli; Nielsen, Line Hagner; Qu, Haiyan; Christensen, Lars Porskjær; Rantanen, Jukka; Yang, Mingshi

doi:10.1016/j.ejpb.2019.01.003

Cited by 16 publications

(11 citation statements)

References 50 publications

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“…This strategy is the simplest process to load the bioactive molecules, since the agents inside the bath are inclined to adsorb at the fiber surface. However, its application is limited owing to an uncontrollable release rate [32,43,68,81]. Blend electrospinning is also a simple process to produce drug-loaded fibers by blending the biomolecules with the polymer solution used for electrospinning.…”

Section: Drug Loaded Electrospun Wound Dressingsmentioning

confidence: 99%

“…In fact, by applying this method, the biomolecules loaded in the core layer are well protected by a sheath [63,82,83]. Blend or coaxial emulsion electrospinning is another approach to encapsulate water-soluble agents [9,32,43]. Coaxial and emulsion electrospinning give rise to well controlled release rate and are able to avoid the initial burst release.…”

Section: Drug Loaded Electrospun Wound Dressingsmentioning

confidence: 99%

“…The incorporation of biological molecules such as growth factors, vitamins, and anti-inflammatory molecules into electrospun fibers is another promising approach to design multifunctional dressings for improving wound healing and skin regeneration [32,89].…”

Section: Electrospun Wound Dressings Loaded With Bioactive Moleculesmentioning

confidence: 99%

“…Nanofibrous scaffolds with appropriate mechanical properties could be proper substrates for cell proliferation. Besides, the incorporation of therapeutic and pharmaceutical agents is used to functionalize electrospun dressings for efficiently targeting different wound types [12,27,[31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

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Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

165

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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Section: Drug Loaded Electrospun Wound Dressingsmentioning

confidence: 99%

Section: Drug Loaded Electrospun Wound Dressingsmentioning

confidence: 99%

Section: Electrospun Wound Dressings Loaded With Bioactive Moleculesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

165

106

View full text Add to dashboard Cite

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“…60,61 The loading of diabetes drugs, 62 antibiotics 58 and bone morphogenetic proteins 63 have been reported. Poly lactide-co-glycolic microspheres (PLGA-MS) was also used in DDS 64 to protect peptides (AMPs) or microbes (such as lysozyme) from rapid degradation. 8,65 PGS.…”

Section: Pclmentioning

confidence: 99%

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

Ren

et al. 2020

J Biomater Appl

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Considering the specificity of periodontium and the unique advantages of electrospinning, this technology has been used to fabricate biodegradable tissue engineering materials for functional periodontal regeneration. For better biomedical quality, a continuous technological progress of electrospinning has been performed. Based on property of materials (natural, synthetic or composites) and additive novel methods (drug loading, surface modification, structure adjustment or 3 D technique), various novel membranes and scaffolds that could not only relief inflammation but also influence the biological behaviors of cells have been fabricated to achieve more effective periodontal regeneration. This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.

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