Stability of resting deoxyglucose metabolic values in PET studies of schizophrenia

Hypofrontality in schizophrenia: a meta‐analysis of functional imaging studies

“…Twenty‐nine studies (9, 12, 13, 16, 17, 31–54) provided global or hemisphere data (in which case left and right values were averaged). The pooled effect size for these was −0.27 (CI −0.39 to −0.15) with the negative sign indicating reduced flow/metabolism in schizophrenia (see Table 1).…”

“…The original 29 studies were not homogeneous ( Q =75.79, P < 0.0001), but homogeneity was achieved by exclusion of seven outliers (9, 31, 34, 40, 42, 45, 47) This reduced the effect size to −0.26 (CI −0.40 to −0.11; Q = 29.60, P = 0.10). Four of the seven outliers had large negative values, but otherwise they showed no common features.…”

“…Twenty‐nine studies reported absolute frontal values (9, 11, 12, 13, 17, 31, 33, 35–37, 39–41, 45, 49–51, 53, 54, 56, 62, 63, 74, 80, 82, 83, 87–90) and these gave a pooled effect size of −0.33 (CI −0.45 to −0.22). These studies were also heterogeneous ( Q = 63.77, P = 0.0001) but homogeneity was achieved by excluding four studies (11, 17, 40, 74).…”

Toward a Neuroimaging Treatment Selection Biomarker for Major Depressive Disorder

“…35,36 Positron emission tomography (PET) scan measurement of glucose metabolism was selected based on its high reliability and availability combined with its established use for studies of baseline scan patterns in depression and effects of various antidepressant treatments. 22,23,28,34,37–43 Our aim was to define an imaging TSB for these 2 potential first-line treatments, ie, a brain activity pattern that distinguishes escitalopram remitters from both escitalopram nonresponders and CBT remitters while concurrently distinguishing CBT remitters from both CBT nonresponders and escitalopram remitters.…”

Effects of Zolpidem on Local Cerebral Glucose Metabolism during Non-REM Sleep in Normal Volunteers: A Positron Emission Tomography Study

“…Repeated studies with magnetic resonance imaging (MRI) have indicated an average repositioning error of about 2 mm (Buchsbaum et al 1992a). Test-retest correlations for FDG PET show that it is a highly reliable method (Bartlett et al 1991). For the PET procedure, subjects slept alone in a dark, quiet individual bedroom and were studied according to previously described methods (Buchsbaum et al 1989).…”