Stabilization and Induction of Oligonucleotide i-Motif Structure <i>via</i> Graphene Quantum Dots

Chen, Xin; Zhou, Xuejiao; Han, Ting; Wu, Jiaying; Zhang, Jingyan; Guo, Shouwu

doi:10.1021/nn304673a

Cited by 52 publications

(54 citation statements)

References 37 publications

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“…[26] Afew carbon-based nanomaterials were reported to induce i-motif even at slightly basic pH, including SWNTs, [27,28] C 60 , [29] and graphene quantum dots. [30] These reports,h owever,did not touch on adsorption affinity,which is the focus of the current work.…”

mentioning

confidence: 95%

“…Thei-motif was observed at pH 7.5 with GO and SWNT ( Figure 4C), consistent with previous reports. [27][28][29][30] However,w ef ailed to see the i-motif at pH 7.5 with the other nanomaterials ( Figure 4D), indicating that the DNAa dsorbed on them as an random coil. As such, the stronger adsorption of poly-C on those materials cannot be attributed to i-motif formation.…”

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confidence: 99%

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Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials

et al. 2017

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Attaching DNA to nanomaterials is the basis for DNA-directed assembly, sensing, and drug delivery using such hybrid materials. Poly-cytosine (poly-C) DNA is a high affinity ligand for four types of commonly used nanomaterials, including nanocarbons (graphene oxide and single-walled carbon nanotubes), transition metal dichalcogenides (MoS and WS ), metal oxides (Fe O and ZnO), and metal nanoparticles (Au and Ag). Compared to other homo-DNA sequences, poly-C DNA has the highest affinity for the first three types of materials. Using a diblock DNA containing a poly-C block to attach to surfaces, the target DNA was successfully hybridized to the other block on graphene oxide more efficiently than that containing a typical poly-A block, especially in the presence of non-specific background DNA, proteins, or surfactants. This work provides a simple solution for functionalizing nanomaterials with non-modified DNA and offers new insights into DNA biointerfaces.

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confidence: 95%

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confidence: 99%

Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials

et al. 2017

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“…It was potential that GQDs could be used as an autophagy-inducing photodynamic agent. X. Chen et al [38] used GQDs to stabilize i-motif structures under acidic conditions. In addition, under alkaline or physiological conditions, GQDs could promote the formation of i-motif structures.…”

Section: Other Biological Applicationsmentioning

confidence: 99%

Hydrothermal/Solvothermal Synthesis of Graphene Quantum Dots and Their Biological Applications

Xu¹,

Li²,

Zhu³

et al. 2013

Nano BioMed ENG

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Graphene quantum dots (GQDs), as a new class of zero dimensional fluorescent carbon material, have been used in physical, chemical and biological aspects for many interesting properties, such as low toxicity, excellent solubility, high chemical stability, and good surface activity. As a green synthetic method, hydrothermal/solvothermal technology has been applied to effectively control characteristics of GQDs. In this review, we summarize recent work on the hydrothermal/solvothermal synthesis of GQDs and their emerging biological applications.

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“…56,62 Of these techniques developed to produce graphene, chemical methods are effective for producing graphene sheets from various precursors on a large scale at low cost, which enables technical applications in a variety of fields. [69][70][71][72][73][74][75] Due to the presence of aromatic domains and multiple oxygen functional groups, GO has more potential applications in biological systems, 44,[53][54][55][56] since it is easier to handle via both covalent and non-covalent functionalization chemistry. [63][64][65][66] The chemistry of graphene has been extensively investigated over the past few years.…”

Section: Brief Introduction To Graphene Physics and Chemistrymentioning

confidence: 99%

The graphene/nucleic acid nanobiointerface

2015

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The combination of nanomaterials with biomolecules yields functional nanostructured biointerfaces with synergistic properties and functions. Owing to a unique combination of its crystallographic and electronic structure, graphene and its derivatives exhibit several superior and typical properties, and has emerged as an attractive candidate for the fabrication of novel nanobiointerfaces with different kinds of unique applications. As is known, nucleic acids are stable and can easily handle modification, and can recognize a wide range of targets with high selectivity, specificity, and affinity. The integration of nucleic acids with graphene-based materials has been substantially advanced over the past few years, achieving amazing properties and functions, thereby exhibiting attractive potential applications in biosensing, diagnostics, drug screening and biomedicine. Herein, this review addresses the recent progress on the design and fabrication of graphene/nucleic acid nanostructured biointerfaces, and the fundamental understanding of their interfacial properties, as well as the various nanobiotechnological applications. To begin with, we summarize the basic features of the graphene and nucleic acid-based nanobiointerface, especially the interfacial interaction mechanism and the resulting biological effects. Then, the fabrication and characterization methodology of graphene and nucleic acid-based nanobiointerfaces are discussed. Next, particular emphasis is directed towards the exploration of their biosensing and biomedical applications, including small molecule detection, protein and DNA sensing/sequencing, as well as gene delivery and therapy. Finally, some significant prospects, further opportunities and challenges in this emerging field are also suggested.

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Stabilization and Induction of Oligonucleotide i-Motif Structure via Graphene Quantum Dots

Cited by 52 publications

References 37 publications

Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials

Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials

Hydrothermal/Solvothermal Synthesis of Graphene Quantum Dots and Their Biological Applications

The graphene/nucleic acid nanobiointerface

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