Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials

Domach, Michael M.; Walker, Lynn M.

doi:10.1016/j.jala.2010.01.002

Cited by 9 publications

(7 citation statements)

References 48 publications

(82 reference statements)

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“…Biodegradable polymers are also known for the successful delivery of a variety of therapeutical agents. Stability of protein can also be increased by using nontoxic Nano-sized substances [52].…”

Section: Protein Stabilitymentioning

confidence: 99%

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Raza

Zafar

Zhu

et al. 2017

Preprint

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Hydrogels evolved as an outstanding carrier material for local and controlled drug delivery that tend to the shortcomings of old conventional dosage forms for small drugs (NSAIDS) and large peptides and proteins. Aqueous swellable and crosslinked polymeric network structure of hydrogels is composed of various natural, synthetic and semisynthetic biodegradable polymers. Hydrogels have remarkable properties of functionality, reversibility, sterilizability, and biocompatibility. All these dynamic properties of hydrogels have increased the interest in their use as a carrier for peptides and proteins to be released slowly in a sustained manner. The therapeutical peptide and proteins are remarkable therapeutic agents in today's world that allows the treatment of severe, chronic and life-threatening diseases, such as diabetes, rheumatoid arthritis, hepatitis in an easy manner. Despite few limitations, hydrogels provide fine tuning of proteins and peptides delivery with enormous impact in clinical medicine. The primary objective of this article is to review current issues concerned with the therapeutics peptides and proteins and impact of remarkable properties of hydrogels on these therapeutic agents. Different routes for pharmaceutical peptides and proteins and superiority over other drugs candidates are presented. The article will also review literature concerning classification of hydrogels on different basis, polymers used, release mechanisms their physical and chemical characteristics and diverse applications.

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Section: Protein Stabilitymentioning

confidence: 99%

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Raza

Zafar

Zhu

et al. 2017

Preprint

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“…Biodegradable polymers have been intensively evaluated for the successful delivery of a variety of therapeutic substances. Protein stability can also be increased using nontoxic nanostructured materials (Domach and Walker, 2010).…”

Section: Protein Stabilitymentioning

confidence: 99%

Development of therapeutic proteins: advances and challenges

Akash¹,

Rehman²,

Tariq³

et al. 2015

Turk J Biol

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Therapeutic proteins have shown to be effective against a variety of diseases. Pharmaceutical companies are progressively focusing on research using proteins in search of novel effective therapeutics. The significant attention by researchers has resulted in considerable advances in the production and usage of therapeutic proteins in recent years. In the current study we focused on the understanding of therapeutic proteins and their impact on the human health care system. Advancements in the field of biotechnology have increased and facilitated the production of therapeutically significant proteins to combat various fatal diseases. Although proteinbased therapeutics have taken center stage in drug discovery and development and enhanced safety for human beings, certain challenges remain, including safety and immunogenicity issues, protein stability, and degradation issues. We made an attempt to discuss all possible factors that are linked with the basis of therapeutic proteins and possible challenges that are currently being faced by scientists during the development of these therapeutic proteins.

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“…A simple and general method to template hydrophilic nanoparticles and proteins into the interstitial spaces of aqueous block copolymer micelle crystal phases to form nanocomposite materials has been presented previously for the cubically-packed micelle phase and the hexagonally-packed cylindrical micelle phase of different block copolymer architectures [14][15][16][17]. A specific architecture of Pluronic ® , denoted P123, is used as a template for nanoparticles in both its cubically-packed spherical micelle and hexagonally-packed cylindrical micelle phases [18].…”

Section: Open Accessmentioning

confidence: 99%

Structural and Mechanical Hysteresis at the Order-Order Transition of Block Copolymer Micellar Crystals

LaFollette

Walker

2011

Polymers

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Concentrated solutions of a water-soluble block copolymer (PEO) 20 -(PPO) 70 -(PEO) 20 show a thermoreversible transition from a liquid to a gel. Over a range of concentration there also exists an order-order transition (OOT) between cubically-packed spherical micelles and hexagonally-packed cylindrical micelles. This OOT displays a hysteresis between the heating and cooling transitions that is observed at both the macroscale through rheology and nanoscale through small angle neutron scattering (SANS). The hysteresis is caused by the persistence of the cubically-packed spherical micelle phase into the hexagonally-packed cylindrical micelle phase likely due to the hindered realignment of the spherical micelles into cylindrical micelles and then packing of the cylindrical micelles into a hexagonally-packed cylindrical micelle phase. This type of hysteresis must be fully characterized, and possibly avoided, for these block copolymer systems to be used as templates in nanocomposites.

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Stabilizing Biomacromolecules in Nontoxic Nano-Structured Materials

Cited by 9 publications

References 48 publications

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Development of therapeutic proteins: advances and challenges

Structural and Mechanical Hysteresis at the Order-Order Transition of Block Copolymer Micellar Crystals

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