Stage at Diagnosis and Mortality in Patients with Adenocarcinoma and Adenosquamous Carcinoma of the Uterine Cervix Diagnosed as a Consequence of Cytologic Screening

Comparative sensitivities of ThinPrep and Papanicolaou smear for adenocarcinoma in situ (AIS) and combined AIS/high-grade squamous intraepithelial lesion (HSIL): Comparison with HSIL

“…1,[5][6][7][8][9] The current results indicate that, for histologic AIS alone, PS and TP have similar sensitivities, whether we define sensitivity as the detection of any abnormality, or as the detection of a high-grade abnormality, or as the detection of a high-grade glandular abnormality.…”

“…Despite a rising incidence of CAC in many countries, [1][2][3][4] there is emerging evidence that cytologic detection of the precursor lesion, adenocarcinoma in situ (AIS), may reduce the incidence of and mortality from CAC. 1,[5][6][7][8][9][10] Although many countries have replaced conventional cervical cytology with liquid-based cytology (LBC), currently in Australia, LBC, mostly ThinPrep (TP), is used as an optional adjunctive test to the conventional Papanicolaou (Pap) smear (PS). Although this may appear cumbersome, one advantage is that it gives us the opportunity to compare paired samples and, consequently, to learn how to recognize the corresponding morphologic appearances on TP slides.…”

Sensitivity and Specificity of the Pap Smear for Glandular Lesions of the Cervix and Endometrium

“…15 Other studies also show that Pap screening leads to earlier detection and improved outcome of ECAC. 13,16 Sensitivity of the Pap smear for ECAC has been reported to be 38.9-83.3% and the false negative or false unsatisfactory rate to be 50-61.1%. [17][18][19] Sensitivity for adenocarcinoma in situ of the cervix (AIC) is 47.6-54.3%.…”

Burden of cervical cancer in the United States, 1998-2003

“…48 Higher mortality rates among black women, especially in the South, may be attributable to higher incidence rates, later stage at diagnosis, and/or disparities in treatment. 26,49 Cancer registry data have some limitations, which had an impact on our study. Although populationbased cancer registries provide an excellent system with which to measure invasive cancers, they do not capture information on HPV types related to cancer or on individual risk factors, such as smoking.…”