Stage Migration and Survival Trends in Laryngeal Cancer

Li, Michael M.; Zhao, Songzhu; Eskander, Antoine; Rygalski, Chandler J.; Brock, Guy; Parikh, Anuraag S.; Haring, Catherine T.; Swendseid, Brian; Zhan, Kevin Y.; Bradford, Carol R.; Teknos, Theodoros N.; Carrau, Ricardo L.; VanKoevering, Kyle K.; Seim, Nolan B.; Old, Matthew; Rocco, James W.; Puram, Sidharth V.; Kang, Stephen Y.

doi:10.1245/s10434-021-10318-1

Cited by 26 publications

(20 citation statements)

References 27 publications

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“…The American Cancer Society also estimates that 12,470 new cases will be diagnosed in the United States in 2022, and 3,820 people will die of laryngeal cancer ( 4 ). Despite the continuous progress of radiation therapy, transoral laser microsurgery and other laryngeal cancer treatments ( 5 ), no significant improvement in the observed survival (OS) or relative survival rate (RS) has been reported ( 6 ). Currently, clinical treatment is selected mainly according to the TNM Classification by the American Joint Commission on Cancer.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in laryngeal cancer: What should we expect from a meta-analysis?

Tian

Sun

et al. 2022

Front. Oncol.

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BackgroundAlthough many studies have shown the predictive value of the high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for various cancers, there are conflicting reports regarding their role in laryngeal cancer. This study aimed to evaluate the relationship between high NLR/PLR and laryngeal cancer prognosis with the help of meta-analysis.MethodsPubMed, Embase and other databases were used to search relevant studies. The pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated using either the random-effect-model or fixed-effect model. Sensitivity analyses and subgroups were used to explore potential sources of heterogeneity. Publication bias was also adopted.Result5716 patients from 20 studies were involved in this meta-analysis. Pooled observed survival (OS) (HR=1.70, 95%CI, 1.41-2.04, p<0.001), progression-free survival (PFS) (HR=1.81, 95%CI, 1.47-2.23, p<0.001), and disease-free survival (DFS) (HR=1.86, 95%CI, 1.45-2.38, p<0.001) showed the prediction of high NLR for poor prognosis. It also suggested that high PLR predicted poor OS (HR=1.89, 95%CI, 1.21-2.94, p<0.001).ConclusionThis study indicated that high NLR was associated with poor OS, PFS, and DFS in laryngeal cancer patients, and high PLR was related to poor OS. Both could be potential predictors of prognosis.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in laryngeal cancer: What should we expect from a meta-analysis?

Tian

Sun

et al. 2022

Front. Oncol.

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“…Over the past two decades, advanced laryngeal carcinoma is the only head and neck cancer subsite that has experienced a decline in rates of survival 6,8,18,23 . Although the reasons for this trend are unknown, some postulate that the reduction in overall survival is secondary to the paradigm shift towards primary treatment with organ preservation strategies instead of upfront total laryngectomy 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Over the past two decades, advanced laryngeal carcinoma is the only head and neck cancer subsite that has experienced a decline in rates of survival. 6,8,18,23 Although the reasons for this trend are unknown, some postulate that the reduction in overall survival is secondary to the paradigm shift towards primary treatment with organ preservation strategies instead of upfront total laryngectomy. 15 Maintaining a functional laryngopharynx is an important goal to strive for in every treatment plan, but studies have suggested that appropriate patient selection is key for achieving organ preservation.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Functional Outcomes in Advanced Laryngeal Squamous Cell Carcinoma

Lee

Sinha

et al. 2022

The Laryngoscope

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Objective Chemoradiation for patients with laryngeal squamous cell carcinoma (SCC) may achieve organ preservation, but appropriate patient selection remains unknown. This study investigates pre‐treatment risk factors associated with functional and survival outcomes after radiation‐based therapy in patients with advanced laryngeal SCC. Methods A retrospective cohort study was performed on 75 adult patients with stage III or IV laryngeal SCC receiving definitive radiation‐based therapy from 1997 to 2016 at a tertiary care center. Tracheostomy and gastrostomy dependence were the primary functional outcomes. Multivariable logistic regressions were performed to evaluate relationships between pre‐treatment factors and tracheostomy and gastrostomy dependence. Time‐to‐event analyses were performed to determine risk factors associated with overall survival. Results Among 75 patients included in the analysis, 30 (40%) patients were tracheostomy dependent and 31 (41%) were gastrostomy tube dependent. The median length of follow‐up was 31 months (range = 1 to 142 months). Pre‐treatment tracheostomy was a significant predictor of post‐treatment tracheostomy (aOR = 13.9, 95% CI = 3.35 to 57.5) and moderate–severe comorbidity was a significant predictor of post‐treatment gastrostomy dependence (aOR = 2.96, 95% CI = 1.04 to 8.43). The five‐year overall survival was 51% (95% CI = 38 to 64%). Pre‐treatment gastrostomy tube dependence was associated with an increased risk of death (aHR = 2.45, 95% CI = 1.09 to 5.53). Conclusions Baseline laryngeal functional status and overall health in advanced laryngeal SCC are associated with poor functional outcomes after radiation‐based therapy, highlighting the importance of patient selection when deciding between surgical and non‐surgical treatment plans. Laryngoscope, 133:594–600, 2023

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“…Laryngeal carcinoma is a common malignant tumor of the head and neck that accounts for approximately one-third of all malignant tumors of the head and neck. The 5-year survival rate for patients with laryngeal carcinoma is only 54.26–56.52% [ 1 ]. The onset of laryngeal carcinoma is obscure, and even distant metastasis occurs in the early stage [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical and experimental study of a terahertz time-domain system for the determination of the pathological margins of laryngeal carcinoma

Jia

et al. 2022

World J Surg Onc

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Objective Laryngeal cancer is a common malignancy in otorhinolaryngological head and neck surgery, accounting for approximately one-third of all head and neck malignancies. Terahertz time-domain spectroscopy (THz-TDS) has recently been found to be useful for the detection of tumors. This study was conducted to investigate the application of THz-TDS in the diagnosis of pathological resection margins of laryngeal cancer. Methods Fresh laryngeal cancer tissues from 10 patients with laryngeal cancer were extracted, and after simultaneous HE staining and terahertz imaging, the tumor area, paracancerous area, and normal tissue area of each laryngeal cancer tissue sample were located under a microscope according to the pathological results of HE staining. Results The shape contours of the tumor region revealed by terahertz imaging maps and HE staining were similar. In the terahertz spectrum in the frequency range of 0.5–1.9 THz, both the absorption coefficient and refractive index values followed the order tumor > para cancer > normal tissue, with statistically significant differences (P < 0.01). When the terahertz frequency was 1.5 THz, the absorption coefficient of terahertz light waves by laryngeal cancer tissue and the percentage of nuclei showed an extremely high positive correlation (P < 0.01, r = 0.971). In the frequency ranges of 0.5–1.2 THz and 1.6–1.9 THz, the absorption coefficients of the highly differentiated group were higher than those of the moderately differentiated group. In the frequency range of 1.2–1.6 THz, the results were reversed, with statistically significant differences (P < 0.05). In the frequency range of 0.5–1.9 THz, the highly differentiated group had a higher refractive index than the moderately differentiated group, with a statistically significant difference (P < 0.05). Conclusions THz-TDS can be used to determine the pathological margins of laryngeal cancer based on the absorption coefficient and refractive index, and the magnitudes of the absorption coefficient and refractive index are related to the percentage of nuclei. The degree of differentiation of laryngeal cancer tissue can be assessed by THz-TDS. The study shows that the terahertz time-domain system is promising for applications in the diagnosis of laryngeal cancer, especially for the more accurate identification of intraoperative margins.

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Stage Migration and Survival Trends in Laryngeal Cancer

Cited by 26 publications

References 27 publications

Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in laryngeal cancer: What should we expect from a meta-analysis?

Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in laryngeal cancer: What should we expect from a meta-analysis?

Risk Factors for Functional Outcomes in Advanced Laryngeal Squamous Cell Carcinoma

Clinical and experimental study of a terahertz time-domain system for the determination of the pathological margins of laryngeal carcinoma

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