Stage of ovarian cancer at diagnosis. Does presentation as an emergency make a difference?

Athey, Ruth A.; Macdonald, Madeleine

doi:10.1016/j.ejogrb.2021.04.001

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…It is worth noting that clear cell cancer constitutes a larger percentage of ovarian cancers in East Asia and have a poorer prognosis compared to serous cancers [ 19 , 32 ]. Our study was concordant with previous ones [ 23 , 33 ]. In our study, there was also difference in histological subtypes between older patients and younger groups.…”

Section: Discussionsupporting

confidence: 94%

Do ethnic chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

et al. 2023

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Background The risk of suffering epithelial ovarian cancer (EOC) for women increases with age evidently, while the prognosis of older EOC patients remain unclear. Against the backdrop of the accelerate aging process in China, this paper investigates whether the older EOC patients have a lower overall survival probability than the younger patients based on the sample of ethnic Chinese population. Methods A total of 323 ethnic Chinese patients diagnosed as epithelial ovarian cancer were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We compared the overall survival probability between the younger group (< 70 years) and the older patients group (≥ 70 years). Survival curves were drawn using the Kaplan-Meier method, comparisons among different subgroups were evaluated using log-rank tests, and independent prognostic factors were identified by univariate and multivariate Cox regression analyses. Results 43 patients were (13.3%) in the older patients group and 280 (86.7%) in the younger group. The distribution patterns between two groups were significantly different with regard to marital status, histologic type and FIGO stage. The median overall survival (OS) was significantly longer in the younger group than the older patients group (not reached vs. median 39 months, p < 0.05). The multivariate analysis demonstrated that the age (The older vs. the younger, HR: 1.967, P = 0.007), primary tumor laterality (HR: 1.849, P = 0.009), and FIGO stage (III vs. I, HR: 3.588, P = 0.001; and IV vs. I, HR: 4.382, P = 0.001; respectively) remained as important risk factors while Histology (HGSOC vs. CCOC, HR: 0.479, P = 0.025; and LGSOC/MOC/EC vs. CCOC, HR: 0.390, P = 0.034; respectively) and the number of lymph node dissected more than 10 was a protective factor (HR: 0.397, P = 0.008). In an analysis of 104 pairs of patients matched on the basis of the propensity score, the older patients group had significantly lower overall mortality (HR = 2.561, P = 0.002). Conclusion Ethnic Chinese Older EOC patients have a worse prognosis than the younger patients.

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Section: Discussionsupporting

confidence: 94%

Do ethnic chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

et al. 2023

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“…Japan, the United States, and Europe showed a similar trend in five-year RS [31]. Older women are more likely to have advanced ovarian cancer at the time of initial diagnosis and have a greater proportion of poorly diagnosed histological subtypes than younger women [32,33] In addition, younger patients often have more aggressive intentions toward treatment than elderly patients. Compared with young ovarian cancer patients receiving more combination treatment, elderly patients are more inclined to monotherapy, which also affects their survival [34].…”

Section: Discussionmentioning

confidence: 86%

Use of Period Analysis to Timely Assess Five-Year Relative Survival for Patients with Ovarian Cancer from Taizhou, Eastern China

Xin

Lei

Zhao

et al. 2023

JCM

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Objective: Ovarian cancer is a deadly gynecologic malignancy with a poor prognosis. It is essential to evaluate the early detection and screening programs of ovarian cancer via timely assessment of long-time survival, particularly in China where those data are incredibly limited. Here, we aimed to provide timely and accurately assessment of long-term survival estimate of ovarian cancer patients from eastern China. Methods: Data of 770 ovarian cancer patients diagnosed between 2004–2018 were obtained from four cancer registries in Taizhou, eastern China, were included. We used period analysis to calculate five-year relative survival (RS) of aforementioned ovarian cancer patients for overall and the stratification by age at diagnosis and region. Results: Our findings demonstrated that the overall five-year RS for ovarian cancer patients in Taizhou between 2014 and 2018 was 69.2%, while urban areas were higher compared to rural areas (77.6% vs. 64.9%). We also observed a significant age gradient with the five-year RS decreasing from 79.6% for age group < 55 years to 66.9% for age group > 74 years. Furthermore, we identified a clear upward trend of five-year RS over the study period, both overall and stratified by region and age at diagnosis. Conclusion: This is the first study in China using period analysis to provide the most up-to-date five-year RS for ovarian cancer patients from Taizhou, eastern China, which reaches 69.2% during 2014–2018. Our results provide valuable information for timely assessment of early detection and screening programs for ovarian cancer in eastern China.

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“…In the current study, ovarian cancer was selected as a case study because it affects women of similar age groups as breast and cervical cancers (CRUK, 2021b ) and has the poorest prognosis among the gynaecological cancers (ONS, 2019a ). Despite this, symptom awareness for ovarian cancer is low (Low et al, 2013 ; Reid et al, 2021 ), and it has high mortality rate due to late diagnosis as outcomes are strongly linked with stage at presentation (Athey et al, 2021 ; ONS, 2019b ). Although ovarian cancer does not have a screening programme (Menon et al, 2021 ), it is important to increase ovarian cancer symptom awareness to improve help‐seeking behaviour for early diagnosis.…”

Section: Introductionmentioning

confidence: 99%

A qualitative exploration of women's perspectives and acceptability of including new cancer awareness information in all‐clear breast or cervical screening results

Bamidele

Green

Tookey

et al. 2022

European J Cancer Care

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Objective This study explored women's perspectives on the acceptability of including new cancer information with an all‐clear breast or cervical screening result letter (using ovarian cancer as a case study). Methods In 2016, six focus group discussions were conducted with women aged 25–70 years old, eligible for invitation to the NHS breast or cervical screening programme and resident in England. The focus groups lasted 60–90 min and were held in community venues. Data were analysed using thematic analysis. Results Thirty‐eight women aged 25–67 years old participated in the focus groups. Data analysis yielded six descriptive themes: general cancer awareness, taking advantage of a ‘teachable moment’, a double‐edge sword, barriers to accepting and using new cancer information, motivators for accepting and using new cancer information and wider strategies to increase cancer awareness in women. Women welcomed the inclusion of new cancer information in all‐clear screening results but highlighted pertinent lessons to be considered to maximise the usefulness of the approach. Conclusion While women perceived this approach as acceptable, it is pertinent to note the potential of the new cancer information to stimulate anxiety and potentially widen inequalities by excluding non‐attenders at screening programmes. Specific complementary and tailored approaches are necessary to mitigate these limitations.

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Stage of ovarian cancer at diagnosis. Does presentation as an emergency make a difference?

Cited by 5 publications

References 9 publications

Do ethnic chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

Do ethnic chinese older adults with epithelial ovarian cancer survive a poorer prognosis?

Use of Period Analysis to Timely Assess Five-Year Relative Survival for Patients with Ovarian Cancer from Taizhou, Eastern China

A qualitative exploration of women's perspectives and acceptability of including new cancer awareness information in all‐clear breast or cervical screening results

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