(±)-Stagonosporopsin A, stagonosporopsin B and stagonosporopsin C, antibacterial metabolites produced by endophytic fungus Stagonosporopsis oculihominis

Wang, Jutao; Li, Huiyuan; Rao, Rao; Yue, Jing-Yi; Wang, Guo-Kai; Yu, Yang

doi:10.1016/j.phytol.2021.08.017

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Stagonosporopsin C (92) exhibited moderate inhibitory activity against S. aureus sub sp. aureus ATCC29213 with a MIC 50 value of 41.3 µM (positive control penicillin G, MIC 50 value 1.963 µM) [59].…”

Section: Minor Taxa Of the Ascomycetesmentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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Section: Minor Taxa Of the Ascomycetesmentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Responses of soil microbial community structure, potential ecological functions, and soil physicochemical properties to different cultivation patterns in cucumber

et al. 2023

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Novel phenolic metabolites isolated from plant endophytic fungus Fusarium guttiforme

Yue

Wang

et al. 2022

Natural Product Research

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Two new phenolic compounds Fusagunolics A (1) and B (2) were isolated from the plant endophytic fungus Fusarium guttiforme, in addition to the previously known metabolites (3-6). The structures of these compounds was elucidated using a combination of spectroscopic analyses, including UV, HRESIMS, 1D, and 2D NMR, as well as electronic circular dichroism (ECD) and the optical rotatory dispersion (ORD).Further, the anti-inflammatory activity of all the compounds was evaluated to assess their capability to inhibit nitric oxide (NO) production by RAW 264.7 macrophages. The bioactive screening revealed that compounds 2 and 6 exhibited moderate inhibitory effects against NO production with the IC50 values 28.6 and 37.6 μM, respectively.

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(±)-Stagonosporopsin A, stagonosporopsin B and stagonosporopsin C, antibacterial metabolites produced by endophytic fungus Stagonosporopsis oculihominis

Cited by 4 publications

References 14 publications

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Responses of soil microbial community structure, potential ecological functions, and soil physicochemical properties to different cultivation patterns in cucumber

Novel phenolic metabolites isolated from plant endophytic fungus Fusarium guttiforme

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