Standard management protocol to improve the short‐term outcome of biliary atresia

Chung, Patrick Ho Yu; Wong, Kenneth K. Y.; Tam, Paul K. H.

doi:10.1111/jpc.14698

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…Recurrent cholangitis is another significant factor which negatively affects native liver survival. Thus, post-KPE patients who present with fever and cholangitis should be promptly treated with antibiotics 163 , 164 .…”

Section: Hepatobiliarymentioning

confidence: 99%

Major surgical conditions of childhood and their lifelong implications: comprehensive review

Cullis,

Fouad,

Goldstein

et al. 2024

BJS Open

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Background In recent decades, the survival of children with congenital anomalies and paediatric cancer has improved dramatically such that there has been a steady shift towards understanding their lifelong health outcomes. Paediatric surgeons will actively manage such conditions in childhood and adolescence, however, adult surgeons must later care for these ‘grown-ups’ in adulthood. This article aims to highlight some of those rare disorders encountered by paediatric surgeons requiring long-term follow-up, their management in childhood and their survivorship impact, in order that the adult specialist may be better equipped with skills and knowledge to manage these patients into adulthood. Methods A comprehensive literature review was performed to identify relevant publications. Research studies, review articles and guidelines were sought, focusing on the paediatric management and long-term outcomes of surgical conditions of childhood. The article has been written for adult surgeon readership. Results This article describes the aforementioned conditions, their management in childhood and their lifelong implications, including: oesophageal atresia, tracheo-oesophageal fistula, malrotation, short bowel syndrome, duodenal atresia, gastroschisis, exomphalos, choledochal malformations, biliary atresia, Hirschsprung disease, anorectal malformations, congenital diaphragmatic hernia, congenital lung lesions and paediatric cancer. Conclusion The increasing survivorship of children affected by surgical conditions will translate into a growing population of adults with lifelong conditions and specialist healthcare needs. The importance of transition from childhood to adulthood is becoming realized. It is hoped that this timely review will enthuse the readership to offer care for such vulnerable patients, and to collaborate with paediatric surgeons in providing successful and seamless transitional care.

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Section: Hepatobiliarymentioning

confidence: 99%

Major surgical conditions of childhood and their lifelong implications: comprehensive review

Cullis,

Fouad,

Goldstein

et al. 2024

BJS Open

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“…BA has caused suffering in thousands of families with disease incidences of 0.05 to 0.14% in live births. Although Kasai portoenterostomy can effectively improve early clinical outcomes, over 70% of BA patients have to ultimately undergo liver transplantation to survive [ 93 ]. Its etiology remains to be fully revealed, but it is known that genetic mutations, exposure to hepatotoxin, and infection by viruses could contribute to the cause of BA [ 92 ].…”

Section: Biomedical Applications Of Bioengineering Liver Organoidsmentioning

confidence: 99%

Bioengineering Liver Organoids for Diseases Modelling and Transplantation

Chu

Lui

et al. 2022

Bioengineering

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Organoids as three-dimension (3D) cellular organizations partially mimic the physiological functions and micro-architecture of native tissues and organs, holding great potential for clinical applications. Advances in the identification of essential factors including physical cues and biochemical signals for controlling organoid development have contributed to the success of growing liver organoids from liver tissue and stem/progenitor cells. However, to recapitulate the physiological properties and the architecture of a native liver, one has to generate liver organoids that contain all the major liver cell types in correct proportions and relative 3D locations as found in a native liver. Recent advances in stem-cell-, biomaterial- and engineering-based approaches have been incorporated into conventional organoid culture methods to facilitate the development of a more sophisticated liver organoid culture resembling a near to native mini-liver in a dish. However, a comprehensive review on the recent advancement in the bioengineering liver organoid is still lacking. Here, we review the current liver organoid systems, focusing on the construction of the liver organoid system with various cell sources, the roles of growth factors for engineering liver organoids, as well as the recent advances in the bioengineering liver organoid disease models and their biomedical applications.

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“…In humans, management after a Kasai operation consists of UDCA for at least 3 months, intravenous antibiotics for at least 2 weeks or longer and fat‐soluble vitamin supplementation (Chung et al . 2020). The clinical benefit of high‐dose glucocorticoid administration for 6 weeks post‐operatively is controversial (Bezerra et al .…”

Section: Congenital Biliary Disordersmentioning

confidence: 99%

“…2014, Chung et al . 2020). Eventually, the majority of humans with EHBA will require a liver transplant in their lives.…”

Section: Congenital Biliary Disordersmentioning

confidence: 99%

Canine hepatobiliary anatomy, physiology and congenital disorders

Jaffey

2021

J of Small Animal Practice

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The biliary system is an integral component of normal physiologic homeostasis and essential for survival. It acts as a conduit for the removal of detoxified and catabolised compounds as well as aids in fat digestion and absorption. Derangements in this system can have dangerous sequela that are associated with varying degrees of morbidity and mortality. Moreover, abnormalities in development of the biliary system can have varied and unpredictable changes on function and long‐term outcome. The aims of this article were to review canine hepatobiliary anatomy, physiology and cholestasis as well as summarise congenital biliary disorders including human corollaries.

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Standard management protocol to improve the short‐term outcome of biliary atresia

Cited by 6 publications

References 26 publications

Major surgical conditions of childhood and their lifelong implications: comprehensive review

Major surgical conditions of childhood and their lifelong implications: comprehensive review

Bioengineering Liver Organoids for Diseases Modelling and Transplantation

Canine hepatobiliary anatomy, physiology and congenital disorders

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