Staphylococcus aureus disease and drug resistance in resource-limited countries in south and east Asia

Nickerson, Emma K.; West, T. Eoin; Day, Nicholas P. J.; Peacock, Sharon J.

doi:10.1016/s1473-3099(09)70022-2

Cited by 87 publications

(62 citation statements)

References 68 publications

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“…The rate of mortality associated with Staphylococcus aureus in developing world exceeds the one of developed countries [25]. The increasing use of antimicrobials against Staphylococcus aureus has led to the development of resistance hence need to develop new antimicrobial agents [26].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Potency of Methanolic Leaf Extracts from Selected Medicinal Plants against Staphylococcus aureus

Ho¹,

Pe²,

Wm³

et al. 2016

J Med Microb Diagn

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The main aim of the study was to test for the antimicrobial potency of Aloe secundiflora, Bulbine frutescens, Tagetes minuta and Vernonia lasiopus against Staphylococcus aureus. All the plants showed a pronounced antimicrobial activity against Staphylococcus aureus with Tagetes minuta being the most active at low concentrations (MIC 8.9 mg/ml; MBC 10.0 mg/ml) whereas Vernonia lasiopus showing less activity (MIC 12.2 mg/ml; MBC 14.2 mg/ml). The efficacy test was carried out using the disc diffusion method. The standard antibiotics used were ciprofloxacin (5 µg/ml) and vancomycin (3 µg/ml) showed significant antimicrobial activity by producing zones of inhibition of 22 mm and 25 mm respectively. Dimethyl sulphoxide and distilled water were used as negative control. The extracts from the plants were also screened for the presence of phytochemicals with the results showing the presence of flavonoids, alkaloids, tannins and saponins in all the extracts. The study suggested that the selected medicinal plants can be used effectively in the treatment of bacterial infection caused by Staphylococcus aureus.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Potency of Methanolic Leaf Extracts from Selected Medicinal Plants against Staphylococcus aureus

Ho¹,

Pe²,

Wm³

et al. 2016

J Med Microb Diagn

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show abstract

“…Both healthy people and those with underlying illness are at risk for diverse skin and soft tissue infections, endocarditis, osteomyelitis, meningitis, bacteremia, and pneumonia [2] with mortality rates ranging from 6% to 40% [3]. Several virulence factors implicated in the pathogenesis of S. aureus strains have been described in the literature [4] which is involved in tissue invasion of the host cells.…”

Section: Introductionmentioning

confidence: 99%

Asymptomatic colonization of Staphylococcus aureus with intermediate resistance to vancomycin harboring vanB resistance gene

Daghistani

Shquirat

Al-kharabsha

et al. 2017

Asian J Pharm Clin Res

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Objective: Vancomycin has been used worldwide due to empirical therapy against methicillin-resistant Staphylococcus aureus infections. As a result a selective pressure that favors the outgrowth of vancomycin intermediate S. aureus clones will be created. This study was carried out to evaluate vancomycin resistance pattern of S. aureus in Jordan.Methods: A total of 1179 samples, including 566 (48%) from human and 613 (52%) from animals were examined for the presence of S. aureus using standard biochemical tests and polymerase chain reaction (PCR) amplification of coa gene. Resistance to antibiotics was determined by the disk diffusion method. Methicillin resistance strains were tested for vancomycin resistance by minimal inhibitory concentration (MIC), E-test, and the results were confirmed by amplification of van genes, and Pulsed-field gel electrophoresis (PFGE). Results:The prevalence of S. aureus among human source was: 19.35%, 14%, and 8.8% for nasal, nail, and skin, respectively, and for animal sources 27.3%, 5.51%, and 15.86% for milk, nasal, and meat, respectively. Four VISA strains (1.87%) were found to colonize human nares, nails, and skin with vancomycin MIC of 4-8 μg/ml. Van B resistance gene was detected and PFGE with SmaI-digested VISA genomic DNA revealed two different pulsotypes. Conclusion:This is believed to be the first report of VISA strains containing vanB gene isolated from a routine carriage survey. Effective screening directed to persons colonized with VISA should therefore be a priority.

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“…The human body consists of a vast repertoire of bacteria, among which the genus Staphylococcus represents the proportion of bacteria that can cause severe infections to the host and majority of these colonize inside new born babies through mother's skin [8,9]. Staphylococcus aureus is a major pathogen in the genus that causes endovascular infections, pneumonia, septic arthritis, endocarditis, osteomyelitis, foreign-body infections and sepsis in hospitals and outpatients [10][11][12][13]. Second most important are those CNS that target neonates through intravascular catheters, prosthetic devices, post-operative sternal wound infections and immune-compromised hosts in the health care environment [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Genome Mining and Comparative Genomic Analysis of Five Coagulase- Negative Staphylococci (CNS) Isolated from Human Colon and Gall Bladder

Nair¹,

Kaur²,

Khatri³

et al. 2016

J Data Mining Genomics Proteomics

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Coagulase-negative Staphylococci (CNS) are known to cause distinct types of infections in humans like endocarditis and urinary tract infections (UTI). Surprisingly, there is a lack of genome analysis data in literature against CNS particularly of human origin. In light of this, we performed genome mining and comparative genomic analysis of CNS strains Staphylococcus cohnii subsp. cohnii strain GM22B2, Staphylococcus equorum subsp. strain equorum G8HB1, Staphylococcus pasteuri strain BAB3 isolated from gall bladder and Staphylococcus haemolyticus strain 1HT3, Staphylococcus warneri strain 1DB1 isolated from colon. We identified 29% of shared virulence determinants in the CNS strains which involved resistance to antibiotics and toxic compounds, bacteriocins and ribosomally synthesized peptides, adhesion, invasion, intracellular resistance, prophage regions, pathogenicity islands. 10 unique virulence factors involved in adhesion, negative transcriptional regulation, resistance to copper and cadmium, phage maturation were also present in our strains. Apart from comparing the genome homology, size and G + C content, we also showed the presence 10 different CRISPR-cas genes in the CNS strains. Further, KAAS based annotation revealed the presence of CNS genes in different pathways involved in human diseases. In conclusion, this study is a first attempt to unveil the pathogenomics of CNS isolated from two distinct body organs and highlights the importance of CNS as emerging pathogens of health care sector. Journal of

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Staphylococcus aureus disease and drug resistance in resource-limited countries in south and east Asia

Cited by 87 publications

References 68 publications

Antimicrobial Potency of Methanolic Leaf Extracts from Selected Medicinal Plants against Staphylococcus aureus

Antimicrobial Potency of Methanolic Leaf Extracts from Selected Medicinal Plants against Staphylococcus aureus

Asymptomatic colonization of Staphylococcus aureus with intermediate resistance to vancomycin harboring vanB resistance gene

Genome Mining and Comparative Genomic Analysis of Five Coagulase- Negative Staphylococci (CNS) Isolated from Human Colon and Gall Bladder

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