Staphylococcus research

Dyke, K. G. H.

doi:10.1099/mic.0.26676-0

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Vancomycin was found to be the most effective drugs against the MRSA isolates among the routinely used antibiotics. There are also reports from many other countries of isolates with reduced susceptibility to vancomycin and teicoplanin frequently associated with a significant thickening of the cell wall (Dyke, 2003). The emergence of vancomycin resistance in Pakistan is an alarming sign as 4% resistance was reported by (Bukhari et al, 2004) but still it remained an effective antibiotic against MRSA (Dar et al, 2006).…”

Section: Discussionmentioning

confidence: 98%

Prevalence of MRSA Containing SCCmec Types Isolated from a Tertiary Care Hospital, Rawalpindi

Arshad¹,

Akhtar²,

Irum³

2015

J. Inf. Mol. Biol.

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| With the changes in epidemiology of methicillin-resistant Staphylococcus aureus (MRSA), accurate information on the scope and magnitude of MRSA infections is needed. This study was conducted to investigate the SCCmec types among MRSA strains collected from a hospital in Rawalpindi. Non-duplicate isolates of Staphylococci were isolated (n=28) from pus specimens (n=100). All strains were tested for methicillin resistance using Cefoxitin disc (30 µg) on Muller-Hinton agar. The phenotypically confirmed isolates (n=22) were screened for the presence of mecA, nuc genes and SCCmec types through multiplex PCR. Both mecA and nuc genes were detected in all Staphylococcus aureus strains, whereas, two SCCmec types III and I were detected in (77.27%) and (31.81%) of isolates, respectively along with subtypes. Antimicrobial susceptibility revealed Vancomycin as the most effective drug against all clinical isolates of MRSA. It is concluded that prevalence of MRSA is quite high in and around Rawalpindi area and thus requires necessary interventions for its effective treatment and control.

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Section: Discussionmentioning

confidence: 98%

Prevalence of MRSA Containing SCCmec Types Isolated from a Tertiary Care Hospital, Rawalpindi

Arshad¹,

Akhtar²,

Irum³

2015

J. Inf. Mol. Biol.

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“…In contrast, the ARDSexp group was characterized by an increase in different background microorganisms compared with the control group, both in terms of positivity and abundance. These microbes have been reported to be widespread, including oral and respiratory sources such as Staphylococcus and Klebsiella ( Hostacka, 2001 ; Dyke, 2003 ) and intestinal microbes such as Erwinia , Lachnospiraceae, Shigella , and Lactobacillus ( Starr and Chatterjee, 1972 ; Baker and The, 2018 ; Vacca et al, 2020 ). Hence, the microbiome of ARDSexp is characterized by an increase in the bacterial load, microbiome diversity, conditionally pathogenic bacteria, and intestinal microbes.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Microbial Composition in Sepsis-Induced Acute Respiratory Distress Syndrome

Zhang

Zheng²,

Yan-tang³

et al. 2022

Front. Mol. Biosci.

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Background: Acute respiratory distress syndrome (ARDS) is an unresolved challenge in the field of respiratory and critical care, and the changes in the lung microbiome during the development of ARDS and their clinical diagnostic value remain unclear. This study aimed to explore the role of the lung microbiome in disease progression in patients with sepsis-induced ARDS and potential therapeutic targets.Methods: Patients with ARDS were divided into two groups according to the initial site of infection, intrapulmonary infection (ARDSp, 111 cases) and extrapulmonary infection (ARDSexp, 45 cases), and a total of 28 patients with mild pulmonary infections were enrolled as the control group. In this study, we sequenced the DNA in the bronchoalveolar lavage fluid collected from patients using metagenomic next-generation sequencing (mNGS) to analyze the changes in the lung microbiome in patients with different infectious site and prognosis and before and after antibiotic treatment.Results: The Shannon–Wiener index indicated a statistically significant reduction in microbial diversity in the ARDSp group compared with the ARDSexp and control groups. The ARDSp group was characterized by a reduction in microbiome diversity, mainly in the normal microbes of the lung, whereas the ARDSexp group was characterized by an increase in microbiome diversity, mainly in conditionally pathogenic bacteria and intestinal microbes. Further analysis showed that an increase in Bilophila is a potential risk factor for death in ARDSexp. An increase in Escherichia coli, Staphylococcus aureus, Candida albicans, enteric microbes, or conditional pathogens may be risk factors for death in ARDSp. In contrast, Hydrobacter may be a protective factor in ARDSp.Conclusion: Different initial sites of infection and prognoses are likely to affect the composition and diversity of the pulmonary microbiome in patients with septic ARDS. This study provides insights into disease development and exploration of potential therapeutic targets.

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The significance of infection related to orthopedic devices and issues of antibiotic resistance

2006

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Staphylococcus research

Cited by 3 publications

References 22 publications

Prevalence of MRSA Containing SCCmec Types Isolated from a Tertiary Care Hospital, Rawalpindi

Prevalence of MRSA Containing SCCmec Types Isolated from a Tertiary Care Hospital, Rawalpindi

Pulmonary Microbial Composition in Sepsis-Induced Acute Respiratory Distress Syndrome

The significance of infection related to orthopedic devices and issues of antibiotic resistance

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