Star‐Shaped Polyacrylates: Highly Functionalized Architectures via CuAAC Click Conjugation

Abstract

Well-defined functional star-shaped polymer structures with up to 29 arms have been successfully synthesized by the combination of atom transfer radical polymerization (ATRP) and click chemistry. First, azide end-functionalized poly(isobornyl acrylate) (PiBA) star-shaped polymers were prepared by successive ATRP and bromine substitution. Subsequently, alkyne end-functionalized molecules and polymers were introduced onto the star-shaped PiBA bearing pendant azide moieties by copper-catalyzed azide-alkyne cycloaddition (CuAAC). The possibilities and limits for the CuAAC on such highly branched polyacrylates are described.

Loss of MTBP expression is associated with reduced survival in a biomarker‐defined subset of patients with squamous cell carcinoma of the head and neck

“…Well‐defined three‐arm star block copolymers could be synthesized in at least three different ways: diblock arms could be grown divergently from a core molecule, preformed linear diblocks could be coupled to a functionalized core, or homopolymer arms could be coupled to the ends of a functionalized three‐arm star homopolymer 54. The last of these three approaches was tested by coupling linear PEG to a PCL three‐arm star core (Scheme )…”

Triazole-forming waterborne polyurethane composites fabricated with silane coupling agent functionalized nano-silica

“…Besides, click chemistry reactions can link particular groups or compounds together through triazole ring and fabricate functional materials. Recently it becomes a very powerful tool in the modification of nano-materials and carbohydrate compounds [8][9][10][11], also in the construction of star polymers [12][13][14][15][16][17][18][19] and polyurethane [20][21][22].…”

Efficient synthesis of zwitterionic sulfobetaine group functional polyurethanes via “click” reaction

“…The reactivity and the grafting rate are moderate. Compared with above methods, click reaction, defined by Sharpless and coworkers,26 offers a powerful method for the controlled manipulation of macromolecular architecture and polymer synthesis because of its quantitative yields, mild reaction condition, and tolerance of a wide range of functional groups 27–36. Recent works by Du Prez have shown that “click” chemistry is a promising tool for side‐chain functionalization of polyurethanes 37, 38…”

“…Compared with above methods, click reaction, defined by Sharpless and coworkers, 26 offers a powerful method for the controlled manipulation of macromolecular architecture and polymer synthesis because of its quantitative yields, mild reaction condition, and tolerance of a wide range of functional groups. [27][28][29][30][31][32][33][34][35][36] Recent works by Du Prez have shown that ''click'' chemistry is a promising tool for sidechain functionalization of polyurethanes. 37,38 We are interested in synthesizing blood compatible polyurethane containing zwitterionic sulfobetaine groups as potential candidate for short-term bloodcontacting applications.…”