Starch‐Based Blends in Tissue Engineering

Carvalho, Pedro P.; Rodrigues, Márcia T.; Reis, Rui L.; Gomes, Manuela E.

doi:10.1002/9781119126218.ch15

Cited by 6 publications

(4 citation statements)

References 89 publications

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“…One enzyme that in the breakdown of chitosan is lysozyme. The degradation rate is determined by the quantity of N-acetyl-glucosamine units (36,37). Chitosan has been shown to possess antibacterial properties against a variety of bacteria and fungi.…”

Section: Chitosanmentioning

confidence: 99%

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Development and Formulation of Drug-Loaded Hydrogel for Cartilage Regenerative Potential

Aravind,

Shanmugarajan

2024

JAZ

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Bone defects resulting from trauma, disease, or congenital abnormalities represent a significant clinical challenge, necessitating advanced regenerative therapies. This study presents the development and formulation of a drug-loaded hydrogel as a novel approach for bone regeneration. The hydrogel matrix is engineered to provide structural support and controlled release of therapeutic agents to enhance bone healing. Various biocompatible polymers and crosslinking strategies are investigated to optimize the hydrogel's mechanical properties, degradation kinetics, and drug release profiles. Furthermore, the study explores the efficacy of different drugs, growth factors, and osteoinductive molecules in promoting osteogenesis and bone tissue regeneration within the hydrogel scaffold. The developed drug-loaded hydrogel holds promise as a versatile platform for addressing diverse bone defects and advancing the field of regenerative orthopedics.

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Section: Chitosanmentioning

confidence: 99%

“…Certain plants, such as potatoes, corn, and wheat, can produce starch. This naturally occurring polysaccharide is found in leaves, fruits, roots, and seeds as 1-110 μm granules (37,3). Starch is commonly employed in the food business because it can be digested and broken down (by amylases) into oligosaccharides to obtain energy (14).…”

Section: Starchmentioning

confidence: 99%

Development and Formulation of Drug-Loaded Hydrogel for Cartilage Regenerative Potential

Aravind,

Shanmugarajan

2024

JAZ

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“…The presence of several hydroxyl groups in the structure of starch, have made possibility of the functionalization of this biopolymer with various functionalities. Based on the biocompatibility and the possibility of the modification of starch, this compound has found applications in several fields, including tissue engineering, [20,21] drug delivery, [22][23][24] and packaging. [25,26] For enhancing the physical, mechanical, and chemical properties of starch, one approach is to fabricate hybrid and composite materials in starch matrix.…”

Section: Introductionmentioning

confidence: 99%

Sulfonic Acid Functionalized Magnetic Starch as an Efficient Catalyst for the Synthesis of Chromeno[4,3‐b]quinoline‐6,8(9H)‐dione Derivatives

et al. 2021

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In this paper, sulfonic acid functionalize magnetic starch (denoted Starch/SPION@SO3H) is fabricated by the polymerization of 4‐styrenesulfonic acid on the surface of magnetic starch. Magnetic starch (Starch/SPION) is synthesized by covalent modification of starch by silica capsulate superparamagnetic iron oxide nanoparticles (SPION). For this purpose, Starch/SPION is modified by allyltrimethoxysilane, follows by the polymerization of 4‐styrenesulfonic acid onto this material. The catalyst is characterized by various characterization techniques, including transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), thermogravimetric analysis (TGA), vibrating‐sample magnetometer (VSM), X‐ray photoelectron spectroscopy (XPS), and acid/base titration. The characterizations prove the structure of Starch/SPION@SO3H catalyst. The catalytic activity of Starch/SPION@SO3H is evaluated in the multicomponent reaction of 4‐hydroxycoumarin, benzaldehydes, dimedone, and ammonium acetate for the synthesis of chromeno[4,3‐b]quinoline‐6,8(9H)‐dione derivatives. The catalyst shows very good activity in the synthesis of chromeno[4,3‐b]quinoline‐6,8(9H)‐dione derivatives. Several benzaldehydes with electron donating or electron withdrawing functionalities are used as starting material and all the substrates give the desired products in high isolated yields. In addition, the catalyst is extremely reusable during 10 sequential runs. Characterization of Starch/SPION@SO3H catalyst by TEM, VSM, and acid/base titration after recovery from the reaction proves the stability of the catalyst in the reaction conditions.

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“…Recently, injectable hydrogels have attracted the attention for bone tissue-engineering applications because they can replace implantation surgery with a minimally invasive injection method and can form any desired shape, to match irregular defects (Liu et al, 2017). For example, starch can be used in the form of bone cement, scaffolds or microparticles in numerous clinical applications (Carvalho et al, 2016).…”

mentioning

confidence: 99%

Optimization of the formulation of an original hydrogel-based bone cement using a mixture design

Monchau

Rémond

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

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Starch‐Based Blends in Tissue Engineering

Cited by 6 publications

References 89 publications

Development and Formulation of Drug-Loaded Hydrogel for Cartilage Regenerative Potential

Development and Formulation of Drug-Loaded Hydrogel for Cartilage Regenerative Potential

Sulfonic Acid Functionalized Magnetic Starch as an Efficient Catalyst for the Synthesis of Chromeno[4,3‐b]quinoline‐6,8(9H)‐dione Derivatives

Optimization of the formulation of an original hydrogel-based bone cement using a mixture design

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