Starch-based nanomaterials in drug delivery applications

Ali, Kazi Asraf; Roy, Pradyot Kumar; Hossain, Chowdhury Mobaswar; Dutta, Dishari; Vichare, Riddhi; Biswal, Manas Ranjan

doi:10.1016/b978-0-12-820874-8.00023-3

Cited by 4 publications

(3 citation statements)

References 131 publications

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“…They are designed to mimic the properties of natural biopolymers and are used in various biomedical applications due to their stability, controlled release, and non-immunogenicity. These polymers can be tailored for specific purposes, such as drug delivery systems, implants, and tissue engineering, and are advantageous over natural biopolymers in terms of flexibility and stability for diverse applications [ 1 , 4 , 5 ].…”

Section: Overview Of Biopolymers and Biocompositesmentioning

confidence: 99%

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Wu,

Khan,

Liao

et al. 2024

Polymers

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The interface between material science and ophthalmic medicine is witnessing significant advances with the introduction of biopolymers in medical device fabrication. This review discusses the impact of biopolymers on the development of ophthalmic devices, such as intraocular lenses, stents, and various prosthetics. Biopolymers are emerging as superior alternatives due to their biocompatibility, mechanical robustness, and biodegradability, presenting an advance over traditional materials with respect to patient comfort and environmental considerations. We explore the spectrum of biopolymers used in ophthalmic devices and evaluate their physical properties, compatibility with biological tissues, and clinical performances. Specific applications in oculoplastic and orbital surgeries, hydrogel applications in ocular therapeutics, and polymeric drug delivery systems for a range of ophthalmic conditions were reviewed. We also anticipate future directions and identify challenges in the field, advocating for a collaborative approach between material science and ophthalmic practice to foster innovative, patient-focused treatments. This synthesis aims to reinforce the potential of biopolymers to improve ophthalmic device technology and enhance clinical outcomes.

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Section: Overview Of Biopolymers and Biocompositesmentioning

confidence: 99%

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Wu,

Khan,

Liao

et al. 2024

Polymers

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“…The results showed improved cellular uptake and cytotoxicity compared to unmodified starch. 71 Another study synthesized chitosan-coated nanoparticles using ultrasound-modified potato starch to deliver curcumin to breast cancer cells in a targeted manner. Because the nanoparticles were made of chitosan and were small, they were extremely stable, released drugs continuously, and were highly uptaken by cells.…”

Section: Targeted Drug Deliverymentioning

confidence: 99%

Ultrasound assisted techniques for starch modification to develop novel drug delivery systems: A comprehensive study

Kumar,

Kumarasamy,

Bhatt

et al. 2024

Journal of Bioactive and Compatible Polymers

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Starch derived from plants plays an essential role in pharmaceuticals due to its components Amylose and Amylopectin, which form essential granules for drug delivery. Its biocompatibility and cost-effectiveness make it indispensable in pharmaceutical formulations, facilitating controlled drug release and tablet breakdown. The effectiveness and safety of drug formulations are often hindered by challenges such as low solubility and stability. In order to overcome these obstacles, current research is focused on modifying the properties of starch. The goal is to improve its solubility, swelling, erosion, stability, and ability to release drugs. A promising solution that has emerged is ultrasound-based modification. This technique has shown great potential in transforming starch granules, leading to improved solubility, degradability, and control over drug release. Not only is this method efficient and quick, but it also has the added benefit of being eco-friendly. This discussion will explore the mechanisms behind the modification of starch based on ultrasound, delving into both the physical and chemical changes that occur in starch granules. The analysis explores the utilization of modified starch induced by ultrasound in the field of drug delivery, investigating its stability and compatibility with biological systems. By exploring the capabilities and difficulties associated with the use of ultrasound to change starch for the delivery of drugs, we highlighted its potential as a leading and effective methodology.

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“…One of the most common polysaccharides, starch, has conventional use in the food industry. Advanced technologies have explored its applications in agriculture, health, medicine, paper, textile, fine chemicals, petroleum and construction engineering sectors [43,44].…”

Section: Introductionmentioning

confidence: 99%

Nontronite-Starch based Nano-Composites and Applications

Bajpai¹

2022

Materials Research Foundations

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Polymer nano-composites consist of two or more constituents with at least one being of nanoscale dimension. Being naturally abundant, affordable, non-toxic and biocompatible, clay-based minerals and biopolymers are advantageous to afford eco-friendly nanocomposites, especially useful for biological applications. Starch, a common polysaccharide, finds traditional use in the food industry, and has recently become relevant in several advanced technologies. Nontronite, an iron rich smectite clay, still remains underexplored in the context of nanocomposite preparation. This book chapter attempts to provide a brief overview of syntheses and applications of nanocomposites based on nontronite, starch and polysaccharide-clay.

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Starch-based nanomaterials in drug delivery applications

Cited by 4 publications

References 131 publications

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Ultrasound assisted techniques for starch modification to develop novel drug delivery systems: A comprehensive study

Nontronite-Starch based Nano-Composites and Applications

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