Starch nanoparticle as a vitamin E-TPGS carrier loaded in silk fibroin-poly(vinyl alcohol)-Aloe vera nanofibrous dressing

Kheradvar, Shadi Alsadat; Nourmohammadi, Jhamak; Tabesh, Hadi; Bagheri, Behnam

doi:10.1016/j.colsurfb.2018.03.004

Cited by 87 publications

(35 citation statements)

References 41 publications

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“…As shown in Figure , drug released from the drug‐loaded MSNs was very quick due to the open pore structure and large surface area of MSNs; moreover, the water soluble drug within the MSNs was inclined to diffuse into the PBS . Similarly, PVA/drug fibers also released the drug very fast in one step . By contrast, drug released from the PVA/MSNs composite nanofibrous mats was more complicated, which underwent two steps.…”

Section: Resultsmentioning

confidence: 99%

“…The excellent hydrophilicity, biocompatibility, and biodegradability of poly(vinyl alcohol) (PVA) have motivated the fabrication of PVA nanofibrous mats for biomedical applications, such as tissue engineering, drug controlled release, and so on . Drug‐loaded hydrophilic PVA nanofibrous mats can be simply fabricated by electrospinning of the aqueous PVA/drug solution, followed by the crosslinking process.…”

Section: Introductionmentioning

confidence: 99%

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Long time release of water soluble drug from hydrophilic nanofibrous material

Pan

Qin

Fan

et al. 2019

J of Applied Polymer Sci

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In this study, mesoporous silica nanoparticles (MSNs) were embedded into the hydrophilic poly(vinyl alcohol) (PVA) nanofibrous mats to achieve sustained release of water soluble drug from hydrophilic nanofibrous mats. MSNs were successfully prepared based on a sol-gel method. Water soluble drug naproxen sodium was then loaded into the mesopores of the MSNs, and different amounts of the drug-loaded MSNs were further incorporated into the fibers by the electrospinning process. Morphology of the nanofibrous mats was investigated, and it was found that all the fibers exhibited fibrous structure. Interestingly, lots of protrusions could be observed from the scanning electron microscopy images with high magnification, and numbers of the protrusions increased with the increasing of loading ratios of the MSNs from 5 to 15%. In addition, the wetting behaviors of the nanofibrous mats were also measured, and the water contact angles of all the mats were measured to be 0 . Finally, the drug release results indicated that all the PVA/MSNs composite nanofibrous mats showed an obviously prolonged drug release. The optimal loading ratio of the MSNs in the nanofibers was 10% due to the slowest drug release rate.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long time release of water soluble drug from hydrophilic nanofibrous material

Pan

Qin

Fan

et al. 2019

J of Applied Polymer Sci

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“…The main goal of drug delivery systems (DDS) is to efficiently deliver drug molecules within the recommended therapeutic level to the target cell, tissue, or organ for a defined period time [34]. A number of researchers have successfully encapsulated drugs within electrospun fibers by mixing the drugs in the polymer solution to be electrospun [7,89,90]. In most cases, polymer nanofibers are being used as candidate vehicles to carry the drug molecules.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…Common antibacterial materials, such as antibiotics, triclosan, chlorhexidine, quaternary ammonium compounds (QACs), and biguanides, have also been reported for use in the fabrication of antibacterial nanofibers [3]. Silk/fibroin nanofibers were also functionalized with a sulfate group in order to test whether they exhibited antibacterial activity [60, 84,90]. A schematic illustration of the main steps for the development of a nanofibrous wound dressing material is displayed in Figure 3.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Electrospinning Technology: Designing Nanofibers toward Wound Healing Application

Coelho¹,

Veleirinho²,

Alberti³

et al. 2020

Nanomaterials - Toxicity, Human Health and Environment

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Electrospinning is a widely used technology to obtain nanofibers. Electrospun systems have been especially investigated for wound dressings in skin regeneration given the similarity of structures with the extracellular matrix. Several efforts have been made to combine distinct design strategies, such as utilizing synthetic and/or natural materials, modifying fiber orientation, and incorporating substances, e.g., drugs, peptides, growth factors or other biomolecules, to develop an optimized electrospun wound dressing. This chapter reviews the current advances in electrospinning strategies for skin regeneration.

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“…1 Severe trauma and certain diseases can cause open wounds in the skin and interfere with its normal structure and function. Because there is a lack of effective interventions, large skin defects can become life threatening; 2 And the USA spends $25 billion a year on wound healing for 6.5 million people. 3 Given the health and economic impact of wound healing, there is a need for wound healing therapy that promotes rapid healing and prevents associated infections Electrical stimulation (ES) of tissues and cells can improve the biological functions of the heart, nerves, bones, and muscles.…”

Section: Introductionmentioning

confidence: 99%

<p>Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization</p>

You

Guo

et al. 2019

IJN

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In this study, we fabricated multifunctional, electrically conductive composites by incorporating graphene oxide (GO) into a poly (lactic-co-glycolic acid) (PLGA) copolymer for wound repair. Furthermore, the resultant composites were coupled with electrical stimulation to further improve the therapeutic effect of wound repair. Methods: We evaluated the surface morphology of the composites, as well as their physical properties, cytotoxicity, and antibacterial activity, along with the combined effects of composites and electrical stimulation (ES) in a rat model of wound healing. Results: Application of the PLGA/GO composites to full-thickness wounds confirmed their advantageous biological properties, as evident from the observed improvements in woundspecific mechanical properties, biocompatibility, and antibacterial activity. Additionally, we found that the combination of composites and ES improved composite-mediated cell survival and accelerated wound healing in vivo by promoting neovascularization and the formation of type I collagen. Conclusion: These results demonstrated that combined treatment with the PLGA/GO composite and ES promoted vascularization and epidermal remodeling and accelerated wound healing in rats, thereby suggesting the efficacy of PLGA/GO+ES for broad applications associated with wound repair.

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Starch nanoparticle as a vitamin E-TPGS carrier loaded in silk fibroin-poly(vinyl alcohol)-Aloe vera nanofibrous dressing

Cited by 87 publications

References 41 publications

Long time release of water soluble drug from hydrophilic nanofibrous material

Long time release of water soluble drug from hydrophilic nanofibrous material

Electrospinning Technology: Designing Nanofibers toward Wound Healing Application

<p>Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization</p>

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