In modern conditions, an important condition for the dynamic development of the Republic of Uzbekistan is the accelerated implementation of the modern innovative technologies in the economy, social and other spheres with widespread use of science and technology. Dynamically developing all spheres of public and state life of the country require close follow-up of ongoing reforms on the basis of modern innovative ideas, developments and technologies that ensure a fast and high-quality breakthrough of the country into the ranks of the world civilization leaders. This determines the relevance of the topic being developed. The paper studies various approaches to the methodology of state support of innovation in economically developed and dynamically developing countries of the world. Based on this analysis, taking into account the characteristics of the national economy, the authors proposed areas of state support for the innovation process in the Republic of Uzbekistan.