State of the art in flexible SERS sensors toward label-free and onsite detection: from design to applications

Xie, Liping; Zeng, Hedele; Zhu, Jiaxin; Zhang, Zelin; Sun, Hongbin; Xia, Wen; Du, Yanan

doi:10.1007/s12274-021-4017-4

Cited by 75 publications

(24 citation statements)

References 243 publications

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“…Flexible substrates attracted much attention in SERS due to the advantage in tunable plasmonic resonances and directly collecting analyte from the curved surface [ 38 , 39 , 40 , 41 , 42 , 43 ]. As a further proof of the flexibility of our fabricated SERS substrate, the flexible SERS substrates were used for detection of pesticide residues on apple surface with a real curved surface.…”

Section: Resultsmentioning

confidence: 99%

Wafer-Scale Fabrication and Transfer of Porous Silicon Films as Flexible Nanomaterials for Sensing Application

Jin

Zhang

et al. 2022

Nanomaterials

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Flexible sensors are highly advantageous for integration in portable and wearable devices. In this work, we propose and validate a simple strategy to achieve whole wafer-size flexible SERS substrate via a one-step metal-assisted chemical etching (MACE). A pre-patterning Si wafer allows for PSi structures to form in tens of microns areas, and thus enables easy detachment of PSi film pieces from bulk Si substrates. The morphology, porosity, and pore size of PS films can be precisely controlled by varying the etchant concentration, which shows obvious effects on film integrity and wettability. The cracks and self-peeling of Psi films can be achieved by the drying conditions after MACE, enabling transfer of Psi films from Si wafer to any substrates, while maintaining their original properties and vertical alignment. After coating with a thin layer of silver (Ag), the rigid and flexible PSi films before and after transfer both show obvious surface-enhanced Raman scattering (SERS) effect. Moreover, flexible PSi films SERS substrates have been demonstrated with high sensitivity (down to 2.6 × 10−9 g/cm2) for detection of methyl parathion (MPT) residues on a curved apple surface. Such a method provides us with quick and high throughput fabrication of nanostructured materials for sensing, catalysis, and electro-optical applications.

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Section: Resultsmentioning

confidence: 99%

Wafer-Scale Fabrication and Transfer of Porous Silicon Films as Flexible Nanomaterials for Sensing Application

Jin

Zhang

et al. 2022

Nanomaterials

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“…The LSPR effect is an electron density wave that propagates along the metal surface due to the interaction between free electrons on the surface of the noble metal nanostructures. As seen in Figure 1B , when the light interacts with the nanoparticle, the incident photons are scattered in different directions, which enhances the light field, electric field, and magnetic field, and increases scattering cross-sections of the sample to make Raman scattering possible ( Li, et al, 2018 ; Lin, et al, 2018 ; Xie, et al, 2022 ). The LSPR performance of Raman enhanced nanoparticles directly affected the sensitivity, repeatability and stability of SERS, which determined the usefulness and reliability of SERS technology.…”

Section: Wearable Surface-enhanced Raman Scattering Sensors：design An...mentioning

confidence: 99%

“…Emerging flexible SERS substrates are attracting unprecedented attention to meet the need for in situ and real-time monitoring for POCT diagnostics. Its applications mainly focus on preparing and applying transparent and flexible SERS active films ( Xie, et al, 2022 ). Hong’s group ( Xu, et al, 2019 ) highlighted three recent types of flexible SERS platforms including tunable SERS, swab sampling SERS, and in situ SERS.…”

Section: Applications In Point-of-care Testing Non-invasive Medical D...mentioning

confidence: 99%

Surface-enhanced Raman scattering as a potential strategy for wearable flexible sensing and point-of-care testing non-invasive medical diagnosis

Liu

Guo

et al. 2022

Front. Chem.

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As a powerful and effective analytical tool, surface-enhanced Raman scattering (SERS) has attracted considerable research interest in the fields of wearable flexible sensing and non-invasive point-of-care testing (POCT) medical diagnosis. In this mini-review, we briefly summarize the design strategy, the development progress of wearable SERS sensors and its applications in this field. We present SERS substrate analysis of material design requirements for wearable sensors and highlight the benefits of novel plasmonic particle-in-cavity (PIC)-based nanostructures for flexible SERS sensors, as well as the unique interfacial adhesion effect and excellent mechanical properties of natural silk fibroin (SF) derived from natural cocoons, indicating promising futures for applications in the field of flexible electronic, optical, and electrical sensors. Additionally, SERS wearable sensors have shown great potential in the fields of different disease markers as well as in the diagnosis testing for COVID-19. Finally, the current challenges in this field are pointed out, as well as the promising prospects of combining SERS wearable sensors with other portable health monitoring systems for POCT medical diagnosis in the future.

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“…The surface-enhanced Raman scattering (SERS) technique has attracted widespread attention due to its wide application in molecular detection, reaction kinetics, biosensors, explosive detection, and art preservation. [1][2][3][4][5][6][7][8][9] There are two main mechanisms contributing to its Raman enhancement effect: the first is the electromagnetic enhancement mechanism (EM) generated by plasma excitations on a rough precious metal surface. In this case, incident light excites the surface plasma excitations of the metal substrate, resulting in enhanced Raman signal molecules on the metal surface.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of Au@palladium oxide nano-sunflowers for ultrasensitive surface-enhanced Raman scattering analysis

Zhao

Liu

et al. 2022

New J. Chem.

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State of the art in flexible SERS sensors toward label-free and onsite detection: from design to applications

Cited by 75 publications

References 243 publications

Wafer-Scale Fabrication and Transfer of Porous Silicon Films as Flexible Nanomaterials for Sensing Application

Wafer-Scale Fabrication and Transfer of Porous Silicon Films as Flexible Nanomaterials for Sensing Application

Surface-enhanced Raman scattering as a potential strategy for wearable flexible sensing and point-of-care testing non-invasive medical diagnosis

Facile synthesis of Au@palladium oxide nano-sunflowers for ultrasensitive surface-enhanced Raman scattering analysis

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