State-of-the-art of 3D printing technology of alginate-based hydrogels—An emerging technique for industrial applications

Mallakpour, Shadpour; Azadi, Elham; Hussain, Chaudhery Mustansar

doi:10.1016/j.cis.2021.102436

Cited by 112 publications

(61 citation statements)

References 88 publications

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“…To overcome these problems, different approaches were used, such as the pre-crosslinking of alginate printing formulations, blending alginate with natural or synthetic polymers, compounding alginate inks with different inorganic fillers or the simultaneous use of these methods [ 11 , 12 , 13 , 14 ]. These approaches were demonstrated as relatively successful solutions, and improvements in the mechanical performance and biofunctionality of 3D-printed, alginate-based scaffolds were registered.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Alginate-Natural Clay Hydrogel-Based Nanocomposites

Alexa

Ianchiş

Savu

et al. 2021

Gels

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Biocompatibility, biodegradability, shear tinning behavior, quick gelation and an easy crosslinking process makes alginate one of the most studied polysaccharides in the field of regenerative medicine. The main purpose of this study was to obtain tissue-like materials suitable for use in bone regeneration. In this respect, alginate and several types of clay were investigated as components of 3D-printing, nanocomposite inks. Using the extrusion-based nozzle, the nanocomposites inks were printed to obtain 3D multilayered scaffolds. To observe the behavior induced by each type of clay on alginate-based inks, rheology studies were performed on composite inks. The structure of the nanocomposites samples was examined using Fourier Transform Infrared Spectrometry and X-ray Diffraction (XRD), while the morphology of the 3D-printed scaffolds was evaluated using Electron Microscopy (SEM, TEM) and Micro-Computed Tomography (Micro-CT). The swelling and dissolvability of each composite scaffold in phosfate buffer solution were followed as function of time. Biological studies indicated that the cells grew in the presence of the alginate sample containing unmodified clay, and were able to proliferate and generate calcium deposits in MG-63 cells in the absence of specific signaling molecules. This study provides novel information on potential manufacturing methods for obtaining nanocomposite hydrogels suitable for 3D printing processes, as well as valuable information on the clay type selection for enabling accurate 3D-printed constructs. Moreover, this study constitutes the first comprehensive report related to the screening of several natural clays for the additive manufacturing of 3D constructs designed for bone reconstruction therapy.

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Section: Introductionmentioning

confidence: 99%

3D Printing of Alginate-Natural Clay Hydrogel-Based Nanocomposites

Alexa

Ianchiş

Savu

et al. 2021

Gels

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“…Recently, food consumers have begun to consider nutrition contents of foods and desire more natural foods instead of the synthetic ones. As a result of that, foods which contain alginate as a natural substance have become more popular [74]. Most importantly, the United State Food and Drug Administration (U.S. FDA) has classified the alginate as "generally regarded as safe" and European Food Safety Authority (EFSA) has recognized to use it in specific doses [75,76].…”

Section: Algal Alginate In Food Sectormentioning

confidence: 99%

“…Most importantly, the United State Food and Drug Administration (U.S. FDA) has classified the alginate as "generally regarded as safe" and European Food Safety Authority (EFSA) has recognized to use it in specific doses [75,76]. In the food sector, alginate has many uses as food production, packaging, thickening and, stabilizing agents, thanks to its unique properties like biodegradability, biocompatibility, renewability, and lack of toxicity [17,74,75,[77][78][79]. It has been noticed that alginate is easily tolerated in human body [80].…”

Section: Algal Alginate In Food Sectormentioning

confidence: 99%

“…The most important problem in this regard is the tendency of food products to deteriorate geometrically. At this point, the alginate improves the water dispersion and thus provides more stable products with good mechanical and thermal behavior [74].…”

Section: Algal Alginate In Food Sectormentioning

confidence: 99%

“…The skin is the biggest organ of the human body and covers all the other organs [74,91,96]. It has three layers: epidermis, dermis, and hypodermis.…”

Section: Algal Alginate In the Cosmetic Industrymentioning

confidence: 99%

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Algal Alginate in Biotechnology: Biosynthesis and Applications

Yarkent¹,

Guler²,

Gürlek³

et al. 2022

Properties and Applications of Alginates

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Algae are recognized as the main producer of commercial alginate. Alginate produced using algae is located in the walls and intracellular regions of their cells. Its properties vary depending on the species, growing and harvesting seasons, and extraction methods. Alginate has attracted the attention of several industries, thanks to its unique properties such as its biodegradability, biocompatibility, renewability and lack of toxicity features. For example, it is considered a good encapsulation agent due to the transparent nature of the alginate matrices. Also, this biopolymer is recognized as a functional food in the food industry. It can be tolerated easily in human body and has the ability to reduce the risk of chronic diseases. Besides, it is used as an abrasive agent, antioxidant, and thickening and stabilizing agents in cosmetic and pharmaceutic industries. Generally, it is used in emulsion systems and wound dressing patches. Furthermore, this polysaccharide has the potential to be used in green nanotechnologies as a drug delivery vehicle via cell microencapsulation. Moreover, it is suitable to adopt as a coagulant due to its wide range of flocculation dose and high shear stability. In this chapter, the mentioned usage areas of algal alginate are explained in more detail.

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Natural Polymer‐Derived Bioscaffolds for Peripheral Nerve Regeneration

Zhang

Guo

Wang

et al. 2022

Adv Funct Materials

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In recent decades, artificial nerve scaffolds have become a promising substitute for peripheral nerve repair. Considerable efforts have been devoted to improving the therapeutic effectiveness of artificial scaffolds. Among numerous biomaterials for tissue engineering scaffolds fabrication, natural polymers are considered as tremendous candidates because of their excellent biocompatibility, low toxicity, high cell affinity, wide source, and environmental protection. With the development of engineering technology, a variety of natural polymer-derived nerve scaffolds have emerged, which are endowed with biological properties and appropriate physicochemical performances to gradually adapt to the needs of nerve regeneration. Significantly, the intergradation of exogenous biomolecules onto the artificial scaffolds is able to avoid low stability, rapid degradation, and redistribution of direct therapeutic drugs in vivo, thereby enhancing nerve regeneration and functional reconstruction. Here, the development of nerve scaffolds derived from natural polymers, and their applications in continuous administration and peripheral nerve regeneration are comprehensively and carefully reviewed, providing an advanced perspective of the field.

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State-of-the-art of 3D printing technology of alginate-based hydrogels—An emerging technique for industrial applications

Cited by 112 publications

References 88 publications

3D Printing of Alginate-Natural Clay Hydrogel-Based Nanocomposites

3D Printing of Alginate-Natural Clay Hydrogel-Based Nanocomposites

Algal Alginate in Biotechnology: Biosynthesis and Applications

Natural Polymer‐Derived Bioscaffolds for Peripheral Nerve Regeneration

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