Stathmin 1 promotes the proliferation and malignant transformation of pancreatic intraductal papillary mucinous neoplasms

Abstract

Abstract. Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are a type of pancreatic tumor, which have been identified following improvements in diagnostic imaging. However, the malignant transformation of IPMN has been difficult to diagnose clinically. To date, the mechanisms driving the progression of IPMN to cancer remain to be fully elucidated. The present study focused on Stathmin 1 (STMN1), a protein that is associated with the development of various types of cancer. The expression of STMN1 was examined immunohistochemically in tissues from cases of IPMN. The correlation between the STMN1 staining and clinical pathological factors was evaluated, and the expression of STMN1, p27 and S-phase kinase-associated protein 2 (SKP2) were compared. High expression levels of STMN1 were significantly correlated with regions of malignancy, and was associated with high expression of SKP2, low expression of nuclear p27 and a high Ki-67 index. High expression levels of STMN1 and SKP2 were significantly correlated with the transformation of IPMN to carcinoma. In addition, within the regions of carcinoma, the expression of STMN1 was weak in regions of adenoma and high in the cancerous regions. It was concluded that the high expression of STMN1 contributed to tumor proliferation and malignant transformation in the patients with IPMN. These results suggested that characterization of the expression of STMN1 may be a promising approach for predicting malignant transformation of pancreatic intraductal papillary mucinous adenoma.

Hsa_circ_0119412 is a tumor promoter in hepatocellular carcinoma by inhibiting miR-526b-5p to upregulate STMN1

“…STMN1 was found to be abnormally expressed in tumors, resulting in the malignant phenotypes of several malignancies, including lung squamous cell carcinoma 14 , pancreatic- 16 , liver- 27 , and breast-cancer 15 . Therefore, STMN1 inhibition could be crucial target for cancer therapy.…”

“…It encodes a ubiquitous cytosolic phosphoprotein belonging to the stathmin family of genes and plays an essential role in the cellular environment aimed at an intracellular relay for integrating regulatory signals. Numerous researchers have confirmed that the dysregulation of the STMN1 gene contributed to tumor progression in lung squamous cell carcinoma 14 , breast cancer 15 , and pancreatic cancer 16 . STMN1 has been found to be elevated in HCC, which has been linked to the occurrence and advancement of cancer 17 , 18 .…”

Overexpression of Stathmin 1 Predicts Poor Prognosis and Promotes Cancer Cell Proliferation and Migration in Ovarian Cancer

“…All the samples were scored as 0, 1, 2, 3, 4, 6, or 9. Samples with scores of 0-4 were considered low expression, and samples with scores of 6-9 were considered high expression [ 21 ]. Evaluation of the stained sections was performed by two pathologists.…”