Stavudine extended release (once-daily, Bristol-Myers Squibb) for the treatment of HIV/AIDS

Mateo, María; Gutierrez, M.; Vidal, Francesc; Domingo, Peré

doi:10.1517/14656566.2013.782285

Cited by 9 publications

(12 citation statements)

References 27 publications

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“…Likewise, the d4T containing regimen was not associated with PN, which is contrary to the findings in other studies [ 27 , 31 , 32 ], however, is similar with the study by Luma et al [ 14 ] which showed no association of d4T use with PN. A possible reason being that people who experience PN as result of d4T have it in the initial stages of the therapy [ 33 , 34 ].…”

Section: Discussionsupporting

confidence: 68%

Prevalence of peripheral neuropathy and its associated demographic and health status characteristics, among people on antiretroviral therapy in Rwanda

et al. 2014

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BackgroundThe introduction of antiretroviral therapy (ART) has dramatically reduced the mortality rate of people living with HIV (PLHIV). However, complications of both HIV and ART, such as peripheral neuropathy currently affect PLHIV. The purpose of this study was to establish the prevalence of peripheral neuropathy of the lower extremity and, its association with demographic and health status, characteristics among people on ART in Rwanda.MethodsA cross sectional study was conducted among 507 women and men aged between 18 and 60 years, on ART, randomly selected from eight selected ART clinics in Rwanda. Brief Peripheral Neuropathy Screen was used to assess peripheral neuropathy.ResultsPeripheral neuropathy prevalence was 59% overall, mean age of the participants was 39.7 (±9.2) and a slightly older age was associated with peripheral neuropathy; [42(±9.2) vs 37 (±8.8) (p < 0.001)]. 78% of participants living in urban settings compared to 40% in rural settings reported peripheral neuropathy, 69% of participants with higher levels of education (secondary level and above) reported lower extremity neuropathy.The three factors were significantly associated with peripheral neuropathy in multivariable model analysis: older age [aOR = 1.1, 95% CI (1.0, 1.2), p < 0.001], primary education level [aOR = 0.6 95% Cl (0.3, 1.0), p = 0.04] and urban setting [aOR = 0.1, 95% CI (0.06, 0.3), p < 0.001], after adjusting for other factors. None of the health status characteristics namely; the level of CD4 cell count, duration of HIV infection and duration on ART, was independently associated with peripheral neuropathy.ConclusionsThe prevalence of peripheral neuropathy among PLHIV on ART in Rwanda is high. It is unclear why urban setting has an effect on PN levels in this cross sectional study, but does suggest that unidentified social and lifestyles factors may have a role in subjective symptoms and objective signs, of PN.

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Section: Discussionsupporting

confidence: 68%

Prevalence of peripheral neuropathy and its associated demographic and health status characteristics, among people on antiretroviral therapy in Rwanda

et al. 2014

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“…Exposure to “D drugs” including d4T has proved to be the most consistent risk factor associated with PN [ 7 , 9 , 41 , 42 ]. However, this study did not find a similar association.…”

Section: Discussionmentioning

confidence: 99%

Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs

Ndakala¹,

Oyugi²,

Oluka³

et al. 2016

Pan Afr Med J

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IntroductionSeveral risk factors including stavudine and age have been strongly associated with polyneuropathy. However, conflicting data exist on height as an independent risk factor in polyneuropathy. The objective of this study is to exclude height as an independent polyneuropathy risk factor in a cohort of human immunodeficiency virus (HIV)-infected Kenyan sex workers.MethodsThis was an analysis of prospectively collected data of treatment-naive subjects initiating either stavudine or tenofovir diphosphate fumarate or zidovudine-based antiretroviral therapy (ART) regimens from January 2008 to August 2012. Polyneuropathy was characterised as burning sensation, numbness, or dysesthesia. The study used arithmetic means of weight (kg) and height (cm) measured in duplicates using calibrated scales.ResultsAfter exclusion of duplicate data sets and un-confirmed cases of polyneuropathy, the study identified 212 patients without polyneuropathy, 14 pre-ART and 94 post-ART related polyneuropathy cases. Polyneuropathy cases were older but did not differ in demographic, clinical and laboratory parameters at baseline. There was a significant difference in first-line ART regimens with more patients on tenofovir disoproxil fumarate in the post-ART group (p=0.017).ConclusionPolyneuropathy is a common disorder among HIV-infected Kenyan sex workers. These data cannot support the postulated increased risk by height after matching for gender and ART duration. Though stavudine is associated with polyneuropathy, in this study many patients previously not exposed to stavudine developed polyneuropathy. This suggests the involvement of unknown risk factors such as genetic and metabolite differences in the development of polyneuropathy.

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“…Simplified strategies have been demonstrated to improve adherence and patient satisfaction in other chronic disease management schema, including cardiovascular disease, hypertension, elevated cholesterol, thrombosis, depression, and osteoporosis [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. In recent decades, increasingly simplified contraception methods have brought with them higher efficacy and patient convenience [34].…”

Section: The Promise Of Drug Simplificationmentioning

confidence: 99%

“…The use of long-acting injectable glucagon-like peptide-1 receptor (GLP-1R) agonists for the treatment of diabetes has been shown to improve glycemic control, glycolated hemoglobin, promote weight loss as well as reduce cardiovascular risk by improving blood pressure control and lipid levels [45][46][47]. Injectable hormones have become the mainstay of long-acting contraception, decreasing unintended pregnancies and abortions while achieving lower failure rates in both resourced and under resourced countries [34,49,50].…”

Section: Long-acting Injectibles (Lais)mentioning

confidence: 99%

Long-Acting, Injectable Antiretroviral Therapy for the Management of HIV Infection: An Update on a Potential Game-Changer

Barnhart¹

2015

J AIDS Clin Res

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Stavudine extended release (once-daily, Bristol-Myers Squibb) for the treatment of HIV/AIDS

Cited by 9 publications

References 27 publications

Prevalence of peripheral neuropathy and its associated demographic and health status characteristics, among people on antiretroviral therapy in Rwanda

Prevalence of peripheral neuropathy and its associated demographic and health status characteristics, among people on antiretroviral therapy in Rwanda

Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs

Long-Acting, Injectable Antiretroviral Therapy for the Management of HIV Infection: An Update on a Potential Game-Changer

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