Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance

Demján, Virág; Sója, Andrea; Kiss, Tivadar; Fejes, Alexandra; Gausz, Flóra Diána; Szűcs, Gergő; Siska, Andrea; Földesi, Imre; Tengölics, Roland; Darula, Zsuzsanna; Csupor, Dezső; Pipicz, Márton; Csont, Tamás

doi:10.1016/j.jtcme.2021.08.003

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…It also decreases swelling and is used as a plaster for fractured bones (Oladeji and Oyebamiji 2020). The antioxidant, anti-microbial (Teușdea et al 2021), anti-diabetic, anti-obesity, cardioprotective (Khan et al 2019;Demján et al 2022), and neuroprotective (Ahmad et al 2022) activities of S. media have been reported. However, the e cacy of S. media on drug-induced gastric toxicity has not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and gastroprotective effect of Stellaria media (L.) Vill. methanolic extract on piroxicam-induced gastric ulcer in Wistar rats

Aleem

Aslam

Alim

et al. 2023

Preprint

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Stellaria media (L.) Vill. is widely distributed throughout the world and is traditionally used to treat inflammatory, respiratory, cardiovascular, and gastrointestinal diseases. This study was designed to phytochemically characterize and investigate the anti-ulcer activity of methanol extract of S. media (SME) in piroxicam (PRX)-induced gastric ulcer in rats. The plant extract was subjected to qualitative as well as quantitative analysis (HPLC and FT-IR) to elucidate the phytochemical composition. In vitro, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay was done to determine the antioxidant capacity. In 14 days of animal study, PRX (30 mg/kg, i.g.) was co-administered with omeprazole (OMP; 20 mg/kg, i.g.) as a standard gastroprotective drug and SME at 150, 300, and 450 mg/kg, i.g., respectively. The gastric pH, acid volume, acidity, ulcer score, hematological parameters, and serum levels of oxidants/antioxidants were determined along with histopathological studies of gastric tissue. Phytochemical analysis showed the presence of considerable phenolic and flavonoid contents which was corroborated with a significant DPPH radical scavenging (IC50: 27.94 µg/mL) activity of extract. Administration of SME at 150, 300, and 450 mg/kg exhibited a dose-dependent gastroprotective effect evidenced by an increase in gastric pH and acidity but a decrease in gastric acid volume, gastric ulcer score, and ulcer index. Treatment with SME normalized the altered hematological parameters and reduced the oxidative stress by decreasing serum levels of TOS and MDA, and increasing the TAC and CAT levels. In addition, histopathological findings supported the aforementioned results. This study concludes that Stellaria media has promising gastroprotective activity against PRX-induced gastric ulcer.

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Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and gastroprotective effect of Stellaria media (L.) Vill. methanolic extract on piroxicam-induced gastric ulcer in Wistar rats

Aleem

Aslam

Alim

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Also, the extract of the S. media plant is known in traditional medicine for its antipyretic, anthelmintic, antioxidant, antimicrobial, and antiobesity effects [12,13]. S. media is a perennial plant that grows in cold or temperate regions and is widely distributed in Europe [8].…”

Section: Introductionmentioning

confidence: 99%

Characterization in Terms of Phytochemical Content and Medicinal Potential of the Stellaria media Plant Extract

Miere¹,

Ganea²,

Teodorescu³

et al. 2023

Pharmacophore

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“…It also lessens swelling and is used as plasters for fractured bone (Oladeji and Oyebamiji 2020). The anti-microbial, anti-leishmanial, anti-in ammatory, antioxidant, anti-diabetic, anti-obesity and anxiolytic activities of S. media have been reported (Khan et al 2019;Miere et al 2021;Ahmad et al 2022;Demján et al 2022). However, the protective effects of S. media on drug-induced gastric toxicity have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and gastro-protective effect of Stellaria media (L.) Vill. methanolic extract on piroxicam-induced gastric ulcer in Wistar rats

Aleem

Aslam

Alim

et al. 2022

Preprint

View full text Add to dashboard Cite

Stellaria media Vill. is widely distributed throughout the world and traditionally used to treat inflammatory, respiratory, heart and gastrointestinal diseases. This study was designed to phytochemically characterize and investigate the anti-ulcer activity of methanol extract of S. media (SME) on piroxicam (PRX)-induced gastric ulcer in rats. The plant extract was subjected to qualitative as well as quantitative analysis (HPLC and FT-IR) to elucidate the phytochemical composition of the extract. DPPH radical scavenging assay was done to determine in vitro antioxidant capacity. In 14 days of animal study, PRX (30 mg/kg, i.g.) was co-administered with omeprazole (OMP; 20 mg/kg, i.g.) as standard gastroprotective drug and SME at 150, 300 and 450 mg/kg, i.g., respectively. The gastric pH, acid volume, acidity, ulcer score, hematological parameters and serum levels of oxidants/antioxidants were determined along with histopathological studies of gastric tissue. Phytochemical analysis showed the presence of considerable phenolic and flavonoid contents which corroborated with a significant DPPH radical scavenging (IC50: 27.94 µg/mL) activity of extract. Administration of SME at 150, 300 and 450 mg/kg exhibited a dose-dependent gastroprotective effect evidenced by increased gastric pH and acidity but decreased gastric acid volume, decreased gastric ulcer score and ulcer index, reversed altered hematological parameters and oxidative stress markers (TOS, MDA, TAC and CAT). In addition, histopathological findings supported the aforementioned results. Conclusively this study suggests that Stellaria media possess promising gastroprotective activity against piroxicam-induced gastric ulcer.

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Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance

Cited by 6 publications

References 49 publications

Phytochemical analysis and gastroprotective effect of Stellaria media (L.) Vill. methanolic extract on piroxicam-induced gastric ulcer in Wistar rats

Phytochemical analysis and gastroprotective effect of Stellaria media (L.) Vill. methanolic extract on piroxicam-induced gastric ulcer in Wistar rats

Characterization in Terms of Phytochemical Content and Medicinal Potential of the Stellaria media Plant Extract

Phytochemical analysis and gastro-protective effect of Stellaria media (L.) Vill. methanolic extract on piroxicam-induced gastric ulcer in Wistar rats

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