Stem cells from trabecular meshwork cells can secrete extracellular matrix

Wang, Elizabeth Xiaomeng; Jiang, Xuemei

doi:10.1016/j.bbrc.2019.12.080

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…While treating glaucoma, the intraocular pressure is still the primary focus of treatment, whereas the trabecular meshwork is the primary location of outflow resistance. It has been suggested that a decrease in TM cells and abnormal ECM are linked to increased resistance to outflow [114]. TM stem cells (TMSC) are abundant in the TM's insert area and are characterised as capable of regenerating TM cells.…”

Section: Trabecular Meshwork Basic Knowledge and Future Directionsmentioning

confidence: 99%

“…TM stem cells (TMSC) are abundant in the TM's insert area and are characterised as capable of regenerating TM cells. Certain animal models, which reflect primary open-angle glaucoma (POAG) phenotypes, are available [114]. However, the effectiveness of TMSCs in TM regeneration and its function is yet to be established.…”

Section: Trabecular Meshwork Basic Knowledge and Future Directionsmentioning

confidence: 99%

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Advancements in Ocular Regenerative Therapies

Tomczak,

Winkler-Lach,

Tomczyk-Socha

et al. 2023

Biology

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The use of stem cells (SCs) has emerged as a promising avenue in ophthalmology, offering potential therapeutic solutions for various vision impairments and degenerative eye diseases. SCs possess the unique ability to self-renew and differentiate into specialised cell types, making them valuable tools for repairing damaged tissues and restoring visual function. Stem cell-based therapies hold significant potential for addressing conditions such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), corneal disorders, and optic nerve damage. Therefore, researchers have explored different sources of stem cells, including embryonic stem cells (ESC), induced pluripotent stem cells (iPSCs), and adult stem cells, for ocular tissue regeneration. Preclinical studies and early-phase clinical trials have demonstrated promising outcomes, with some patients experiencing improved vision following stem cell-based interventions. However, several challenges remain, including optimising the differentiation protocols, ensuring transplanted cells’ safety and long-term viability, and developing effective delivery methods. The field of stem cell research in ophthalmology witnesses a constant influx of new reports and discoveries. To effectively navigate these tons of information, it becomes crucial to summarise and systematise these findings periodically. In light of recent discoveries, this paper demonstrates the potential applications of stem cells in ophthalmology, focusing on their use in various eye tissues, including the cornea, retina, conjunctiva, iris, trabecular meshwork, lens, ciliary body, sclera, and orbital fat.

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Section: Trabecular Meshwork Basic Knowledge and Future Directionsmentioning

confidence: 99%

Section: Trabecular Meshwork Basic Knowledge and Future Directionsmentioning

confidence: 99%

Advancements in Ocular Regenerative Therapies

Tomczak,

Winkler-Lach,

Tomczyk-Socha

et al. 2023

Biology

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show abstract

“…The reduction in trabecular cell density thus affects renewal of the ECM and provokes the accumulation of debris, leading to increased outflow resistance in glaucomatous eyes. Theoretically, recolonization of the trabecular meshwork from stem cells could compensate for the cell loss in glaucomatous eyes and allow the trabecular meshwork to regain its function, thus reducing IOP [22,117].…”

Section: Cell Therapymentioning

confidence: 99%

The trabecular meshwork: Structure, function and clinical implications. A review of the literature

Buffault

Labbé

Hamard

et al. 2020

Journal Français d'Ophtalmologie

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Glaucoma is a blinding optic neuropathy, the main risk factor for which is increased intraocular pressure (IOP). The trabecular meshwork, located within the iridocorneal angle, is the main pathway for drainage of aqueous humor (AH) out of the eye, and its dysfunction is responsible for the IOP elevation. The trabecular meshwork is a complex, fenestrated, threedimensional structure composed of trabecular meshwork cells (TMC) interdigitated into a multilayered organization within the extracellular matrix (ECM). The purpose of this literature review is to provide an overview of current understanding of the trabecular meshwork and its pathophysiology in glaucoma. Thus, we will present the main anatomical and cellular bases for the regulation of aqueous humor outflow resistance, the pathophysiological mechanisms involved in trabecular dysfunction in the various types of glaucoma, as well as current and future therapeutic strategies targeting the trabecular meshwork.

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“…The P75 neurotrophin receptor (p75NTR) or p75 nerve growth factor receptor (NGFR) or CD271 are mesenchymal stem cell markers [ 154 , 155 , 156 ] that are expressed in non-neuronal cell types (fibroblasts, macrophages [ 157 ], chondroblasts, adipocytes, osteoblasts [ 158 , 159 ]) during inflammation in the skin caused by any wound [ 157 ]. Asai et al [ 160 ] reports the biomedical functionality of Prolyl-hydroxyproline (Pro-Hyp) collagen through activation of P75 receptors.…”

Section: Receptors-based Collagenmentioning

confidence: 99%

Developments for Collagen Hydrolysate in Biological, Biochemical, and Biomedical Domains: A Comprehensive Review

et al. 2021

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The collagen hydrolysate, a proteinic biopeptide, is used for various key functionalities in humans and animals. Numerous reviews explained either individually or a few of following aspects: types, processes, properties, and applications. In the recent developments, various biological, biochemical, and biomedical functionalities are achieved in five aspects: process, type, species, disease, receptors. The receptors are rarely addressed in the past which are an essential stimulus to activate various biomedical and biological activities in the metabolic system of humans and animals. Furthermore, a systematic segregation of the recent developments regarding the five main aspects is not yet reported. This review presents various biological, biochemical, and biomedical functionalities achieved for each of the beforementioned five aspects using a systematic approach. The review proposes a novel three-level hierarchy that aims to associate a specific functionality to a particular aspect and its subcategory. The hierarchy also highlights various key research novelties in a categorical manner that will contribute to future research.

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Stem cells from trabecular meshwork cells can secrete extracellular matrix

Cited by 5 publications

References 26 publications

Advancements in Ocular Regenerative Therapies

Advancements in Ocular Regenerative Therapies

The trabecular meshwork: Structure, function and clinical implications. A review of the literature

Developments for Collagen Hydrolysate in Biological, Biochemical, and Biomedical Domains: A Comprehensive Review

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