Stem cells: potency, plasticity and public perception*

Abstract

Production of chimaeras with embryonal carcinoma and embryonic stem cells enabled a very thorough investigation of the potency of these cells in the mouse. Human embryonal carcinoma and embryonic stem cell differ from their murine counterparts in a number of respects and, for obvious reasons, their potency is more difficult to assess.Recently, findings attesting to a surprising degree of plasticity of cells from adults have begun to emerge, which, aside from offering a possible further route to stem cell therapy, raise intriguing questions about the importance of lineage in the process of cellular diversification. Biomedical research is widely perceived to be advancing too fast to allow proper consideration of the implications of its clinical applications. Whilst this was clearly not true in the case of human in vitro fertilization, it has some validity regarding stem cell therapy, even though many of the issues are common to both. Casual use of the term 'embryo' proved unhelpful in the past debate on whether research on early stages of human development should be permitted. Likewise, introduction of the term 'therapeutic cloning' has complicated the present one regarding extension of such research to stem cell therapy.

Stem cells derived from testis show promise for treating a wide variety of medical conditions

“…Cells can become undetermined and undifferentiated in special circumstances. These undifferentiated cells which are capable of self-renewal and differentiation into more specialized cells are termed as stem cells [4,5]. Stem cells have the remarkable potential to develop into many different cell types in the body.…”

Role of regeneration in tissue repairing and therapies

“…But controlling the cell death pathway and its regulatory signals can finish the tumor. Similarly, regulators of cell lineage, activation of cell cycle, and transformation of two similar daughter cells in two different cell types lead to development of functional differences [9]. Thus, new cell lineage different from parental cells starts due to genetic and environmental reasons during embryonic stages.…”

Dental Kök Hücre Kaynaklari Ve Kemi̇k Doku Rejenerasyonunda Kullanilma Potansi̇yelleri̇

“…12,13,15 Pluripotent kök hücreler, mezodermal, ektodermal ve endodermal kökenli olmak üzere, vücuttaki farklılaşmış tüm hücre tiplerini oluşturabilme potansiyeline sahip hücrelerdir. 16 Multipotent Hücreler embriyonik kök hücreler farklılaşarak birçok farklı hücre tipine dönüştüğü 20-,22 Embriyonel kök hücrelerin sınırsız olarak çoğalabilme kabiliyetleri vardır. 12,19 Aynı zamanda, bu hücrelerin kontrolsüz çoğalma ve tümör oluşturma potansiyelleri de vardır.…”