Stepwise assembly of functional proteins on Photo-activated TiO2 surfaces confers anti-oxidative stress ability and stealth effect to vascular stents

Cui, Jiawei; He, Siming; Dai, Sheng; Liu, Luyin; Zhao, Ansha; Lü, Lei; Yang, Ping; Jiang, Chen; Huang, Nan

doi:10.1016/j.cej.2021.130392

Cited by 13 publications

(7 citation statements)

References 60 publications

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“…M2 macrophages secreted anti-inflammatory and pro-repair factors, such as interleukin IL-10. The main inflammatory factor secreted by macrophages was TNF-α . Apoptosis of ECs, delayed endothelial regeneration, and smooth muscle hyperplasia during stent implantation were generally closely related to the increase of TNF-α.…”

Section: Resultsmentioning

confidence: 96%

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Allicin-Loaded Intelligent Hydrogel Coating Improving Vascular Implant Performance

Han,

Lu,

Zou

et al. 2023

ACS Appl. Mater. Interfaces

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Coronary atherosclerosis is closely related to inflammation and oxidative stress. Owing to poor biocompatibility, lack of personalized treatment, and late toxic side effects, traditional drug-eluting stent intervention, releasing antiproliferative drugs, can delay endothelial repair and cause late thrombosis. The inflammation caused by atherosclerosis results in an acidic microenvironment and oxidative stress, which can be considered as triggers for precise and intelligent treatment. Here, we used catechol hyaluronic acid (C-HA) and cystamine (Cys) to prepare C-HA-Cys hydrogel coatings by amide reaction. The H 2 S-releasing donor allicin was loaded in the hydrogel to form an intelligent biomimetic coating. The disulfide bond of Cys made the crosslinked network redox-responsive to the inflammation and oxidative stress in the microenvironment by releasing the drug and H 2 S intelligently to combat the side effects of stent implantation. This study evaluated the hemocompatibility, anti-inflammatory capacity, vascular wall cytocompatibility, and in vivo histocompatibility of this intelligent hydrogel coating. Furthermore, the effect of H 2 S released from the coating on atherosclerosis-related signaling pathways such as CD31 and cystathionine γ-lyase (CSE), CD36, and ACAT-1 was investigated. Our results indicate that the C-HA-Cys-Allicin hydrogel coating could be manufactured on the surface of vascular interventional devices to achieve a precise response to the microenvironment of the lesion to release drug, which can attain the purpose of prevention of in-stent restenosis and ensure the effectiveness and safety of the application of interventional devices.

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Section: Resultsmentioning

confidence: 96%

“…Apoptosis of ECs, delayed endothelial regeneration, and smooth muscle hyperplasia during stent implantation were generally closely related to the increase of TNF-α. Also, TNF-α induced the aggregation of macrophages. − …”

Section: Resultsmentioning

confidence: 99%

Allicin-Loaded Intelligent Hydrogel Coating Improving Vascular Implant Performance

Han,

Lu,

Zou

et al. 2023

ACS Appl. Mater. Interfaces

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“…The results of the high-resolution spectrum of C1s on the TiO 2 surface, shown in Figures 1D, E , indicated that the piranha solution treatment significantly oxidized the oxygenated hydrocarbon adsorbates on the TiO 2 surface, as the shoulder peak at 288.55 eV on the TiO 2 surface was red-shifted to 289.0 eV after the treatment ( Cui et al, 2021 ). This phenomenon is consistent with that of TiO 2 after UV irradiation.…”

Section: Resultsmentioning

confidence: 99%

Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials

Liao

Chen

Jiang

et al. 2023

Front. Bioeng. Biotechnol.

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Blood contact materials require strong anti-fouling capabilities to avoid thrombus formation. Recently, TiO2-based photocatalytic antithrombotic treatment has gained focus. Nevertheless, this method is restricted to titanium materials with photocatalytic abilities. This study offers an alternative solution that can be applied to a broader range of materials: piranha solution treatment. Our findings revealed that the free radicals generated by the treatment effectively altered the surface physicochemical properties of various inorganic materials, enhancing their surface hydrophilicity and oxidizing organic contaminants, thus improving their antithrombotic properties. Additionally, the treatment resulted in contrasting effects on the cellular affinity of SS and TiO2. While it significantly reduced the adhesion and proliferation of SMCs on SS surfaces, it significantly enhanced these on TiO2 surfaces. These observations suggested that the impact of the piranha solution treatment on the cellular affinity of biomaterials was closely tied to the intrinsic properties of the materials. Thus, materials suitable for piranha solution treatment could be selected based on the functional requirements of implantable medical devices. In conclusion, the broad applicability of piranha solution surface modification technology in both blood-contact and bone implant materials highlights its promising prospects.

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“…138 Inspired by the presence of natural enzymes in the body that fight against ROS, Chen et al utilized catalase and autologous albumin to modify titanium dioxide (TiO 2 ) cardiovascular stents via the stepwise assembly, thus constructing a biological stealth and anti-oxidative stress surface. 139 Depending on the anti-oxidative effect of catalase and the anticoagulation effect of albumin, modified cardiovascular stents hindered the fibrinogen-mediated coagulation cascades and protected ECs from free radical damage (Fig. 8A).…”

Section: Current Research Progress On Cardiovascular Stents At the La...mentioning

confidence: 99%

Restoring endothelial function: shedding light on cardiovascular stent development

Wang

Feng

2023

Biomater. Sci.

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Stepwise assembly of functional proteins on Photo-activated TiO2 surfaces confers anti-oxidative stress ability and stealth effect to vascular stents

Cited by 13 publications

References 60 publications

Allicin-Loaded Intelligent Hydrogel Coating Improving Vascular Implant Performance

Allicin-Loaded Intelligent Hydrogel Coating Improving Vascular Implant Performance

Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials

Restoring endothelial function: shedding light on cardiovascular stent development

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