Stereospecific ligands and their complexes IX: Synthesis, characterization and antimicrobial activity of ethyl esters of (S,S)-ethylenediamine-N,N′-di-2-propanoic and (S,S)-ethylenediamine-N,N′-di-2-(3-methyl)-butanoic acids and corresponding platinum(IV) complexes: Crystal structure of tetrachloride-(O,O′-diethyl-(S,S)-ethylenediamine-N,N′-di-2-propanoato)-platinum(IV), [PtCl4(det-S,S-eddp)]

Stanković, Milena Z.; Glođović, Verica V.; Radojević, Ivana D.; Stefanović, Olgica D.; Čomić, Ljiljana R.; Klisurić, Olivera R.; Djinovic, Vesna M.; Trifunović, Srećko R.

doi:10.1016/j.poly.2011.05.034

Cited by 5 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The other two equatorial positions of the octahedron are occupied by the nitrogen atoms N1 and N2 of the ester ligand. Bond lengths and angles were found to be in the expected range of other platinum complexes 16,18,[25][26][27][28] (see ESIw, Table S2). The chelating N1,N2 ester ligand gives rise to the formation of a five-membered ring, exhibiting an envelope conformation on C1 (ca.…”

Section: Resultsmentioning

confidence: 99%

Platinum(ii/iv) complexes containing ethylenediamine-N,N′-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells

et al. 2012

View full text Add to dashboard Cite

Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(ii) and platinum(iv) complexes of the general formula [PtCl(n)(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, (1)H and (13)C NMR) and elemental analysis. The crystal structure of platinum(iv) complex [PtCl(4){(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(ii), and platinum(iv) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.

show abstract