Stereospecific ligands and their complexes. XI: Synthesis, characterization and antimicrobial activity of palladium(II) complexes with some alkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(3-methyl)-butanoic acid

Synthesis and structural characterization of Pd(II) complexes derived from perimidine ligand and their in vitro antimicrobial studies

“…El-Sherif and co-workers have reported the higher activity of the complexes as compared to the free ligand which can further be understood in terms of the chelation theory. This theory explains that a decrease in the polarizability of the metal could enhance the lipophilicity of the complexes [38,40]. comparative study revealed that complex 1 showed larger zones (16-19 mm) as compared to complex 2 (9-12 mm) which is larger as compared to ligand (7-9 mm) with all the tested strains.…”

“…Symmetry transformations used to generate equivalent atoms: #1: 1 À x, À1/2 + y, 1/2 À z. e.g., gastroenteritis, urinary tract infections, and hospitalacquired infections [40,41].…”

Promising Antimicrobial Activity of an Oxime Based Palladium(II) Complex

“…Medicinal inorganic chemistry has been receiving positive impact over the last few decades due to the promising manifested activity of these therapeutic agents compared to organic‐based drugs . Since 1940s, the development of antibacterial drugs and the enhancement of drug resistance capabilities of the bacterial cells towards these newly developed drugs are simultaneously going on . Again, the fungal infections have also been rising alarmingly specifically for immunocompromised people .…”

“…Palladium(II) complexes of only N‐donor ligands also show antimicrobial activity . The N‐ and O‐donor palladium complexes were also found to exhibit weak antifungal and antibacterial activities . Again, Schiff‐bases generated from ortho ‐hydroxyl substituted aromatic aldehydes have been kindling renewed interest in coordination chemistry due to their N‐ and O‐donor sites .…”

Stereospecific ligands and their complexes. XXII. Synthesis and antitumor activity of palladium(II) complexes with some esters of (S,S)-ethylenediamine-N,N′-di-(2,2′-di(4-hydroxy-benzyl))-acetic acid

“…In vitro antitumor activity of some complexes was compared to that of cisplatin [23][24][25][26][27], and as a results of these findings N,N bidentate esters, R 2 edda-type ligands, containing hiral C-atoms with S absolute configuration originating from natural aminoacids are now mostly used in our studies. Recently, we have reported the synthesis and characterization of the palladium(II) complexes with dialkyl esters of [(S,S)-H 2 -R 2 eddip]Cl 2 [28], H 2 -S,S-eddp [29], H 2 -(S,S)-eddv [30], H 2 -(S,S)-eddba [31], (R = ethyl, n-propyl, n-butyl and n-pentyl) and their antitumor and antimicrobial activities. As continuation of our work we report herein the synthesis, characterization and cytotoxicity of four novel R 2 edda-type ligand…”