Steroidal Saponins from Rhizomes of Tupistra wattii Hook. f.

Abstract

Steroids Steroids U 0300Steroidal Saponins from Rhizomes of Tupistra wattii Hook. f. -[isolation, structure elucidation and cytotoxicity of three new spirostanol saponins such as (I)] -(SHEN, P.; WANG, S.-L.; LIU, X.-K.; YANG, C.-R.; CAI, B.; YAO*, X.-S.; Chem.

Antifungal Saponins from the Maya Medicinal Plant Cestrum schlechtendahlii G. Don (Solanaceae)

“…(), this is the first report of antifungal activity by this compound. Other spirostanol saponins isolated from the Solanaceae as well as from other plant families have also been reported to have antifungal activities (Alvarez et al ., ; Haraguchi et al ., ; Shen et al ., ; González et al ., ; Yang et al ., ; Lu et al ., ). Our observation that compound 1 inhibits growth of the human pathogens C. albicans and C. neoformans suggests it has potential applications in treating mycoses such as ringworm, athletes foot, and onychomycoses fungal infections of the nails.…”

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

“…T. chinensis, T. wattii, and T. yunnanensis are main sources of spirostanol and furostanol saponins. Sixty-five compounds were assigned as spirostanol saponins (Table 1 and Figure 2), 2,[7][8][9][10]21,22,24,28,[31][32][33]35,36,39 while compounds 85 to 150 are furostanol saponins (Table 1 and Figure 3). 5,8,10,18,22,24,31,35,37,[39][40][41][42][43][44][45][46][47] Taking spirostanol saponins into consideration, glycosylation generally happens at C-1, C-3, C-5, and C-24.…”

“…In the genus Tupistra, convallagenin A 3-O-β-D-glucopyranoside (30) and convallagenin B 5-O-β-D-glucopyranoside (31) have only been isolated from the rhizomes of T. chinensis and T. wattii, respectively. 9,32 The underground part of T. chinensis seems to be a good reservoir of spirostanol saponins. Based on physicochemical results and NMR spectral analysis, Song et al reported that the 65% EtOH extract of T. chinensis underground parts contained 2 new spirostanol saponins, (24S,25R)-1β-hydroxy-3β-[(β-Dglucopyranoside)oxy]-spirost-5-en-24-yl-β-D-glucopyranoside (34), and (24S)-spirost-25 (27)-en-1β,3β,4β,5β,6β,24β-hexahydroxy-24-O-β-D-glucopyranoside (59), in addition to 2 known ones, 3-epi-diosgenin-3-β-D-glucopyranoside (32), and 25(R)-1β-hydroxy-spirost-5-en-3α-yl-O-β-D-glucopyranoside [3-epi-ruscogenin-3-β-D-glucopyranoside] (35).…”

“…There have been numerous studies using both Tupistra secondary metabolites and extracts for pharmacological examinations, which may be classified into: cytotoxic, 3,7,8,10,22,23,26,28,[32][33][34][35][36]38,39,41,48,54,55 anti-inflammation, 9,10,22,37,39,44,[56][57][58] antimicrobial, 4,19 antioxidant, 4 antidiabetic, 4 and other beneficial effects. 56 An overview of previous pharmacological evaluations of Tupistra plants are discussed in detail and outlined in Table 2.…”

“…9,32 The underground part of T. chinensis seems to be a good reservoir of spirostanol saponins. Based on physicochemical results and NMR spectral analysis, Song et al reported that the 65% EtOH extract of T. chinensis underground parts contained 2 new spirostanol saponins, (24S,25R)-1β-hydroxy-3β-[(β-Dglucopyranoside)oxy]-spirost-5-en-24-yl-β-D-glucopyranoside (34), and (24S)-spirost-25 (27)-en-1β,3β,4β,5β,6β,24β-hexahydroxy-24-O-β-D-glucopyranoside (59), in addition to 2 known ones, 3-epi-diosgenin-3-β-D-glucopyranoside (32), and 25(R)-1β-hydroxy-spirost-5-en-3α-yl-O-β-D-glucopyranoside [3-epi-ruscogenin-3-β-D-glucopyranoside] (35). 8 In 2016, Xiang et al reported that the 60% EtOH extract of T. chinensis rhizome was characterized by the presence of 18 new compounds, (25R)-5β-spirostan-1β,3β-diol-3-O-β-D-fructofuranosyl-(2→6)-β-D-glucopyranoside (46), (25R)-5β-spirostan-1β, 3α-diol-3-O-β-D-glucopyranoside (47) 9,10,22,39 Thus, the root and rhizome of T. chinensis may be thought of as a rich resource of new spirostanol saponins.…”