Stevens-Johnson Syndrome while on lamotrigine and NSAID:A case report

Abstract

Stevens-Johnson syndrome is a severe immune-mediated cutaneous reaction occurring due to exposure to certain drugs. Lamotrigine is an FDA approved drug used in the treatment of bipolar depression. When it is given concomitantly with sodium valproate, the risk of developing Stevens-Johnson syndrome increases. Here we present the report of a patient with bipolar depression who developed serious skin rashes while on lamotrigine and NSAID prescribed by a local doctor, who recovered after timely management. This case highlights the importance of following proper dosing, drug escalation regimen and managing drug interactions during lamotrigine therapy.

Oxcarbazepine-induced Toxic Epidermal Necrolysis: A Rare Case Report

“…Various studies have shown phenytoin, carbamazepine, and lamotrigine to be the most common anticonvulsants causing SJS-TEN. 2 OXC, a 10-keto derivative of CBZ, is thought to be safer due to its distinct metabolism. 3 Oxcarbazepine is metabolized to its active metabolite, monohydroxy derivative (MHD) in contrast to carbamazepine which is readily metabolized to an epoxide metabolite.…”