Stevens-Johnson Syndrome With Supraglottic Laryngeal Obstruction

Koch, Wayne M.; McDonald, Graeme A.

doi:10.1001/archotol.1989.01860350115026

Cited by 13 publications

(3 citation statements)

References 15 publications

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“…A retrospective study of 32 SJS/TEN cases found 50% to have abnormal lung function tests during routine follow-up (61). In the published literature, RS involvement following SJS/TEN has been characterized by chronic lung disease, bronchiolitis obliterans, interstitial lung disease, pulmonary air leak syndrome, laryngeal obstruction, and obliterative bronchitis, among others (57,(61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76). The genitourinary system is also not spared in SJS/TEN.…”

Section: Internal Organ Involvement As An Additional Marker Of Steven...mentioning

confidence: 99%

Disease severity and status in Stevens–Johnson syndrome and toxic epidermal necrolysis: Key knowledge gaps and research needs

Lehloenya

2022

Front. Med.

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Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are on a spectrum of cutaneous drug reactions characterized by pan-epidermal necrosis with SJS affecting < 10% of body surface area (BSA), TEN > 30%, and SJS/TEN overlap between 10 and 30%. Severity-of-illness score for toxic epidermal necrolysis (SCORTEN) is a validated tool to predict mortality rates based on age, heart rate, BSA, malignancy and serum urea, bicarbonate, and glucose. Despite improved understanding, SJS/TEN mortality remains constant and therapeutic interventions are not universally accepted for a number of reasons, including rarity of SJS/TEN; inconsistent definition of cases, disease severity, and endpoints in studies; low efficacy of interventions; and variations in treatment protocols. Apart from mortality, none of the other endpoints used to evaluate interventions, including duration of hospitalization, is sufficiently standardized to be reproducible across cases and treatment centers. Some of the gaps in SJS/TEN research can be narrowed through international collaboration to harmonize research endpoints. A case is made for an urgent international collaborative effort to develop consensus on definitions of endpoints such as disease status, progression, cessation, and complete re-epithelialization in interventional studies. The deficiencies of using BSA as the sole determinant of SJS/TEN severity, excluding internal organ involvement and extension of skin necrosis beyond the epidermis, are discussed and the role these factors play on time to healing and mortality beyond the acute stage is highlighted. The potential role of artificial intelligence, biomarkers, and PET/CT scan with radiolabeled glucose as markers of disease status, activity, and therapeutic response is also discussed.

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Section: Internal Organ Involvement As An Additional Marker Of Steven...mentioning

confidence: 99%

Disease severity and status in Stevens–Johnson syndrome and toxic epidermal necrolysis: Key knowledge gaps and research needs

Lehloenya

2022

Front. Med.

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“…Acute laryngitis, epiglottitis, and ulceration of the nasal cavity and the true and false vocal cords have all been documented since the 1940s [69,70]. The majority of described cases resolve in the acute setting with supportive therapy and/or airway management.…”

Section: Otorhinolaryngologicmentioning

confidence: 99%

Complications of Stevens–Johnson syndrome beyond the eye and skin

Saeed

Mantagos

Chodosh

2016

Burns

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“…8 Other reported etiologies include smoke inhalation, Stevens-Johnson syndrome, paraquat ingestion, and autoimmune disorders such as Crohn disease. [9][10][11][12] Patients will present with hoarseness, cough, dyspnea, wheezes, stridor, and, occasionally, respiratory failure. Diagnosis requires a high index of suspicion, and should be confirmed with a comprehensive bronchoscopic examination and biopsy.…”

Section: Introductionmentioning

confidence: 99%

Necrotizing Tracheitis Secondary to Corynebacterium Species Presenting With Central Airway Obstruction

Guerrero¹,

Mallur²,

Folch³

et al. 2013

Respir Care

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Pseudomembranous necrotizing tracheitis is a rare cause of life-threatening central airway obstruction. Patients present with hoarseness, cough, dyspnea, wheezing, stridor, and occasionally with respiratory failure. Diagnosis requires a high index of suspicion, and should be confirmed with a comprehensive bronchoscopy and biopsy. For patients with signs and symptoms of airway obstruction, a therapeutic rigid bronchoscopy with mechanical debridement is recommended. We present a rare case of necrotizing tracheitis secondary to Corynebacterium species, which caused life-threatening airway obstruction in an adult.

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Stevens-Johnson Syndrome With Supraglottic Laryngeal Obstruction

Cited by 13 publications

References 15 publications

Disease severity and status in Stevens–Johnson syndrome and toxic epidermal necrolysis: Key knowledge gaps and research needs

Disease severity and status in Stevens–Johnson syndrome and toxic epidermal necrolysis: Key knowledge gaps and research needs

Complications of Stevens–Johnson syndrome beyond the eye and skin

Necrotizing Tracheitis Secondary to Corynebacterium Species Presenting With Central Airway Obstruction

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