Still's disease and the virus-associated haemophagocytic syndrome.

Hemophagocytic Syndrome and Adult Still's Disease Associated with Meningoencephalitis and Unconsciousness.

“…In contrast, HPS in children complicated by Still's disease primarily presented with HPS symptoms (4)(5)(6)(7)(8). This 19-year-old patient, who was an adolescent and not a child, revealed symptoms of HPS, followed by those ofASD.…”

Macrophage activation syndrome associated with systemic juvenile idiopathic arthritis

“…A SAM pode ser desencadeada por agentes infecciosos virais como varicela-zoster 13 , hepatite A 14 , Epstein-Barr 8 e coxsackie B 15 , bem como terapia com ouro, ácido acetilsalicílico e outros antiinflamatórios não-hormonais 6,12 , methotrexate 10 , sulfasalazina e penicilamina 7 .…”

Síndrome de ativação macrofágica associada com artrite idiopática juvenil sistêmica

“…Among patients with systemic JIA, the association of MAS with infectious agents has been described, on average one to two weeks after the onset of infection by the hepatitis A virus, 14 the varicella-zoster virus, 13 coxsackie B virus 15 and the Epstein-Barr virus. 8,26 Other associations such as: Pneumocystis carinii, salmonelosis 27 cytomegalovirus, rubella, human immunodeficiency virus, bacterial diseases such as tuberculosis, leishmaniasis, brucellosis and syphilis; neoplasms and prolonged soluble lipid use have all been described.…”

“…10,11 The presence of numerous macrophages in the bone marrow phagocytosing blood cells (hemophagocytosis), with no evidence of malignancy is characteristic of MAS. 3,12 Macrophage activation syndrome can be triggered by viral infectious agents such as: varicella-zoster, 13 hepatitis A, 14 Epstein-Barr 8 and coxsackie B, 15 in addition to therapy with gold, acetylsalicylic acid and other nonsteroidal antiinflammatory drugs, 6,12 methrotrexate, 10 sulfasalazine and penicillamine. 7 The etiopathogenesis of MAS is unknown.…”