Stimulation of thyroid cell proliferation by epidermal growth factor is different from cell growth induced by thyrotropin or insulin-like growth factor I

Bechtner, G.; Schopohl, Dorothee; Rafferzeder, M.; Gärtner, Roland; Welsch, Ulrich

doi:10.1530/eje.0.1340639

Cited by 27 publications

(21 citation statements)

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“…The decreased slope in transgenic mice suggests that there may be an impaired response of thyroid follicle cells to TSH, with regard to thyroid hormone synthesis. This is consistent with previous reports that IGF-I plays a facilitatory role in TSHinduced thyroid hormone synthesis (3,32).…”

Section: Discussionsupporting

confidence: 94%

“…However, the relative increase in RTW following goitrogen treatment compared with the untreated group was less pronounced in transgenic mice than in wild-type mice, despite the difference in TSH levels. This supports the concept that IGF-I is involved in TSH-mediated growth (3,32) and that the overexpression of IGFBP-1 in transgenic mice impairs TSH action (27,33). Serum levels of T 3 and T 4 were decreased in transgenic, compared with wild-type mice.…”

Section: Discussionsupporting

confidence: 83%

“…IGF-I, the IGF-I receptor and a variety of IGF-binding proteins (IGFBPs) are expressed in thyroid tissue (1,2). IGF-I facilitates thyrotropin (TSH)-induced proliferation of dog thyroid epithelium in vitro (3) and rat thyroid cell lines in culture (4,5). Increased expression of IGF-I receptors has been documented in thyroid tissue from Graves' disease patients (6) and IGF-I has been implicated in the development of multinodular goiters (7).…”

Section: Introductionmentioning

confidence: 99%

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Thyroid gland function and growth in IGF binding protein-1 transgenic mice

Modric

Rajkumar²,

Murphy³

1999

European Journal of Endocrinology

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Objective: IGF-I, IGF-I receptor and IGF-binding proteins (IGFBPs) are expressed in thyroid tissue and are associated with the function and growth of the thyroid. This study investigated the in vivo and in vitro effects of increased IGFBP-1 levels on the function and growth of the thyroid gland. Design: Transgenic mice which constitutively overexpress IGFBP-1 were used. These mice have a phenotype consistent with partial inhibition of IGF-I action. Methods: Thyroid growth, morphology and hormonogenesis were determined in transgenic mice treated with goitrogens, sodium perchlorate and methimazole. In vitro cell proliferation in thyroid follicles was assessed in response to IGF-I and TSH. Results: Thyroid weight was increased in transgenic mice, relative to their body mass, whereas serum tri-iodothyronine (T 3 ), thyroxine and T 3 -binding capacity were reduced, compared with wildtype. While an inverse relationship between T 3 and TSH was observed in both groups of goitrogentreated mice, the slope of the line of best fit was less steep in transgenic mice compared with wild-type mice. Thyroid growth was less marked in transgenic than wild-type mice in response to goitrogens, although TSH levels were higher in goitrogen-treated transgenics. In vitro proliferative response of isolated thyroid follicles to IGF-I, but not to TSH, was reduced in transgenic, compared with wild-type mice. Conclusions:The results of this study suggest that, while overexpression of IGFBP-1 attenuates IGF-I action in vitro, it enhances thyroid growth in vivo, presumably as a result of perturbations in thyroid function at multiple levels.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid gland function and growth in IGF binding protein-1 transgenic mice

Modric

Rajkumar²,

Murphy³

1999

European Journal of Endocrinology

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“…As reported by Bechtner et al (1996), many in vitro studies investigating thyroid cell function and growth have been carried out on single cells. However, these authors argue that the follicle organization of thyroid cells is important for the maintenance of polarization, speci®c functions and the regulation of cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

The influence of l -triiodothyronine, l -thyroxine, estradiol-17β, the luteinizing-hormone-releasing hormone, the epidermal growth factor and gastrin on cell proliferation in organ cultures of 35 benign and 13 malignant human thyroid tumors

Nagy

Camby

Decaestecker

et al. 1999

Journal of Cancer Research and Clinical Oncology

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Triiodothyronine, thyroxine, LHRH and gastrin may increase or decrease cell proliferation in human thyroid tissues, whether benign or malignant, to the same extent as other hormones and/or growth factors such as thyrotropin, EGF, insulin-like growth factor 1, transforming growth factor beta1 and estradiol the effects of which on thyroid cell proliferation are already well documented in the literature.

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“…Thus, it may be possible that IGF may affect thyroid cells, and play a role in the development of thyroidal diseases. Studies have revealed that this molecule facilitates thyroid epithelium proliferation, induced by thyroid stimulating hormone in animal studies (9,10). Increased expression of IGF-1 receptors has been documented in thyroid tissue in patients with Graves' disease and thyroid cancer (11,12), and the relationship between the tissue and serum levels of IGF-1 and the development of multinodular goiter has also been shown (13,14).…”

Section: Introductionmentioning

confidence: 99%

The Role of Insulin-Like Growth Factor 1 in the Development of Benign and Malignant Thyroid Nodules

Baştürk¹,

Kement²,

Yavuzer³

et al. 2012

Balkan Med J

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Objective: This study aims to investigate the role of IGF-1 in the development of nodular thyroid disease. Material and Methods:A total number of 100 consecutive patients operated for nodular thyroid disease in our institution were included in this prospective study. In addition to classical pathological examinations, nodules and extranodular healthy tissues were sampled and immunochemically stained for IGF-1. The materials were independently evaluated using an Allred Scoring System ranging from 0 to 8. If the score was ≥1, the tissue was accepted as IGF-1 positive.Results: IGF-1 positivity was observed in 88% and 58% of the samples obtained from nodules and extranodular healthy tissues, respectively. Allred 8-unit scores were higher in benign nodules (n=89; 4.1±2.3) and papillary carcinomas (n=7; 6.7±1.3), than in extranodular healthy tissues in the same patients (2.3±2.3 and 3.3±1.9, respectively); and higher in papillary carcinomas than in benign nodules, when the scores were compared to each other (p<0.01 for all comparisons).Conclusions: Allred 8-unit scores for IGF-1 increase in the presence of benign thyroid nodules, papillary cancer. The results of our study support the findings of previous studies demonstrating the role of IGF-1 in the development of thyroidal nodules.

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Stimulation of thyroid cell proliferation by epidermal growth factor is different from cell growth induced by thyrotropin or insulin-like growth factor I

Cited by 27 publications

References 0 publications

Thyroid gland function and growth in IGF binding protein-1 transgenic mice

Thyroid gland function and growth in IGF binding protein-1 transgenic mice

The influence of l -triiodothyronine, l -thyroxine, estradiol-17β, the luteinizing-hormone-releasing hormone, the epidermal growth factor and gastrin on cell proliferation in organ cultures of 35 benign and 13 malignant human thyroid tumors

The Role of Insulin-Like Growth Factor 1 in the Development of Benign and Malignant Thyroid Nodules

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